Photophysicochemical behaviour of phenoxy propanoic acid functionalised zinc phthalocyanines when grafted onto iron oxide and silica nanoparticles: Effects in photodynamic antimicrobial chemotherapy

Antimicrobial Photodynamic Therapy: Latest Developments with a Focus on Combinatory Strategies

“…As a result, such magnetic NPs have legitimately generated interest and use as magnetic resonance imaging (MRI) and magnetic particle imaging (MPI) agents, as well as magnetic fluid hyperthermia (MFH), magnetic cell separators [145], or drug delivery conveyers with the possibility to guide the NPs to the targeted area via external magnetic fields [146]. More recently, iron oxide nano-objects proved to be also of pertinence for aPDT applications not only as a magnetic "nanocargo" for various organic and inorganic PSs such as curcumin, MB, ICG, BODIPYs, porphyrins, metallophtalocyanines, or ruthenium derivatives among others [27,108,[147][148][149][150][151][152][153][154][155], but also with peroxidase-like activity to enhance the cleavage of biological macromolecules for biofilm elimination [156] [27,117,147,150,151,[157][158][159][160].…”

“…Furthermore, SiO 2 exhibits an effective PS-grafting capacity [226]; the latter can be accomplished via adsorption, covalent bonding, binding to the hydroxyl groups from silica surface, and entrapment during formation in silica particles or matrix [27]. Recently, Dube et al reported about the photo-physicochemical behavior of silica NPs with (3-aminopropyl)triethoxysilane (APTES), and subsequently PS-modified surfaces for aPDT [150]. In addition, silica coatings have also been reported to prevent the degradation of nanocarriers (magnetite) and prolong the stability and functionality of PS systems [227].…”

Nipagin-Functionalized Porphyrazine and Phthalocyanine—Synthesis, Physicochemical Characterization and Toxicity Study after Deposition on Titanium Dioxide Nanoparticles P25

“…Various macrocycles can also be embedded on the formed surface of the oxide nanoparticles during their synthesis [ 36 ]. Alternatively, the nanoparticles can be appended with various linkers (i.e., by silylation), which allows for covalent bond formation between the nanoparticles and the photosensitizers [ 26 ]. Finally, the interactions could consist in weak bonds between the photosensitizers and the unmodified surface of the nanoparticles, or the chemical groups present on their surfaces after functionalization, i.e., hydrophobic interactions with the long PEG chains [ 37 ].…”

“…The obtained hybrid material was studied as a catalyst mimicking peroxidase activity, and revealed its activity for glucose detection. Dube et al combined the designed Pcs with Fe 3 O 4 /SiO 2 nanoparticles with an amide bond using an aminopropylsilyl linker [ 26 ]. The proposed approach gave access to functionalized nanoparticles of potent antimicrobial activity.…”

APTES-Modified Remote Self-Assembled DNA-Based Electrochemical Biosensor for Human Papillomavirus DNA Detection

“…Modification of APTES leads to the formation of APTES membranes, which have an amino group as the terminal group. The amino group is able to react with a variety of groups; therefore, researchers are keen to select APTES as a coupling agent to other chemical bonds in their studies [ 24 ]. In previous studies on the immobilization of DNA molecules using APTES SAM, it was found that the good connection performance between APTES SAM and DNA is mainly caused by two reasons.…”