Photophysics and photochemistry of tetrahydrocurcuminoids

Castellan, Alain; Ruggiero, Reinaldo; Silva, Leandro G. da; Portes, Elise; Grelier, Stéphane; Gardrat, Christian

doi:10.1016/j.jphotochem.2007.03.019

Cited by 6 publications

(2 citation statements)

References 35 publications

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“…The high value of k r of 5×10 5 s −1 coupled with the relatively low value of 5.5×10 4 s −1 for k nr account for the bright emission. This contrasts strikingly with THC itself, which is only very weakly emissive in ethanol solution at room temperature ( Φ =0.007) …”

Section: Resultsmentioning

confidence: 59%

A Highly Luminescent Tetrahydrocurcumin Ir^III Complex with Remarkable Photoactivated Anticancer Activity

Colombo

Fontani

Dragonetti

et al. 2019

Chemistry A European J

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Curcumin has chemopreventative properties against a variety of tumours, but has poor bioavailability. Here, two new bis‐cyclometallated iridium(III) complexes have been prepared, featuring the natural product curcumin (CUR) or its reduced form, tetrahydrocurcumin (THC), as bidentate, anionic O O‐binding ligands. The iridium THC complex is highly luminescent in deoxygenated solution and efficiently generates singlet oxygen under aerated conditions, whereas in the CUR analogue, other non‐radiative decay pathways are competitive. The complexes are rapidly taken up by a variety of human tumour cell lines from solutions of micromolar concentration. They show negligible cytotoxicity in the absence of irradiation. When briefly irradiated with visible light, Ir‐THC becomes highly phototoxic, inducing rapid apoptosis within 2 h. The results show the high potential of such complexes as sensitizers in photodynamic therapy (PDT).

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Section: Resultsmentioning

confidence: 59%

A Highly Luminescent Tetrahydrocurcumin Ir^III Complex with Remarkable Photoactivated Anticancer Activity

Colombo

Fontani

Dragonetti

et al. 2019

Chemistry A European J

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“…The addition of THC showed a slight increase of the absorbance in the visible light range (400–800 nm) and a strong increase in the UV range (200–400 nm) due to the absorption peak of THC around 280 nm with a shoulder at 310 nm [ 54 ]. Furthermore, the increase of the absorbance around 210 nm may be related to the photo-oxidized THC [ 55 ]. Nevertheless, no relevant difference was observed among collagen scaffolds with THC.…”

Section: Resultsmentioning

confidence: 99%

3D-Printed Mucoadhesive Collagen Scaffolds as a Local Tetrahydrocurcumin Delivery System

et al. 2021

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Native collagen doughs were processed using a syringe-based extrusion 3D printer to obtain collagen scaffolds. Before processing, the rheological properties of the doughs were analyzed to determine the optimal 3D printing conditions. Samples showed a high shear-thinning behavior, reported beneficial in the 3D printing process. In addition, tetrahydrocurcumin (THC) was incorporated into the dough formulation and its effect on collagen structure, as well as the resulting scaffold’s suitability for wound healing applications, were assessed. The denaturation peak observed by differential scanning calorimetry (DSC), along with the images of the scaffolds’ surfaces assessed using scanning electron microscopy (SEM), showed that the fibrillar structure of collagen was maintained. These outcomes were correlated with X-ray diffraction (XRD) results, which showed an increase of the lateral packaging of collagen chains was observed in the samples with a THC content up to 4%, while a higher content of THC considerably decreased the structural order of collagen. Furthermore, physical interactions between collagen and THC molecules were observed using Fourier transform infrared (FTIR) spectroscopy. Additionally, all samples showed swelling and a controlled release of THC. These results along with the mucoadhesive properties of collagen suggested the potential of these THC–collagen scaffolds as sustained THC delivery systems.

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Environmentally friendly films based on chitosan and tetrahydrocurcuminoid derivatives exhibiting antibacterial and antioxidative properties

Portes

Gardrat

Castellan

et al. 2009

Carbohydrate Polymers

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Photophysics and photochemistry of tetrahydrocurcuminoids

Cited by 6 publications

References 35 publications

A Highly Luminescent Tetrahydrocurcumin Ir^III Complex with Remarkable Photoactivated Anticancer Activity

A Highly Luminescent Tetrahydrocurcumin Ir^III Complex with Remarkable Photoactivated Anticancer Activity

3D-Printed Mucoadhesive Collagen Scaffolds as a Local Tetrahydrocurcumin Delivery System

Environmentally friendly films based on chitosan and tetrahydrocurcuminoid derivatives exhibiting antibacterial and antioxidative properties

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Photophysics and photochemistry of tetrahydrocurcuminoids

Cited by 6 publications

References 35 publications

A Highly Luminescent Tetrahydrocurcumin IrIII Complex with Remarkable Photoactivated Anticancer Activity

A Highly Luminescent Tetrahydrocurcumin IrIII Complex with Remarkable Photoactivated Anticancer Activity

3D-Printed Mucoadhesive Collagen Scaffolds as a Local Tetrahydrocurcumin Delivery System

Environmentally friendly films based on chitosan and tetrahydrocurcuminoid derivatives exhibiting antibacterial and antioxidative properties

Contact Info

Product

Resources

About

A Highly Luminescent Tetrahydrocurcumin Ir^III Complex with Remarkable Photoactivated Anticancer Activity

A Highly Luminescent Tetrahydrocurcumin Ir^III Complex with Remarkable Photoactivated Anticancer Activity