Photopic Negative Response Obtained Using a Handheld Electroretinogram Device: Determining the Optimal Measure and Repeatability

Abstract

The PhNR can be measured for clinical and research purposes using a simple-to-implement technique that is consistent within and between visits, and also between examiners.

Factors Affecting Mydriasis-Free Flicker ERGs Recorded With Real-Time Correction for Retinal Illuminance: Study of 150 Young Healthy Subjects

“…The components of the RETeval system have been described in detail. [16][17][18][19][20][21][22][23] In brief, full-field stimuli are presented with a 60-mm diameter dome, and the white stimuli are created by a combination of three colored light emitting diodes. The frequency of the flicker stimulus was 28.306 Hz, and the pulse duration was less than 1 msec.…”

“…A full-field flicker ERG recording system called the RETeval system was recently developed. [16][17][18][19][20][21] This system is comprised of a small, hand-held Ganzfeld dome used with a special single-use, skin electrode array. This system can record flicker ERGs without mydriasis because the device delivers stimulus flashes with constant retinal illuminance (Td-s) by adjusting the luminance (cd-s/m 2 ) to compensate for changes in the pupillary area (mm 2 ) in real time.…”

Early impairment of the full‐field photopic negative response in patients with Stargardt disease and pathogenic variants of the ABCA4 gene

“…On a practical level, the presence of PhNR alterations in most Stargardt patients shows that the PhNR is a very sensitive disease read‐out, outperforming other full‐field ERG parameters. Considering the ease with which full‐field ERGs can be recorded in normal ophthalmological practice, including the evaluation of the PhNR in the standard ERG tests could be an almost effortless addition of significant consequence in Stargardt diagnosis and follow‐up.…”

Relationship between structural and functional changes in glaucomatous eyes: A multifocal electroretinogram study

“…However, the PhNR can be measured in several different ways, either as the negative trough following the b-wave or at a xed time point [7][8][9]. Wu et al recently reported that the PhNR to B-wave ratio (PhNR/B; B-wave amplitude de ned as the a-wave trough to bwave peak) exhibited the lowest magnitude of test-retest variability and concluded that PhNR/B was the optimal measure of the PhNR [10].…”