Photopolymerized maleilated chitosan/thiol-terminated poly (vinyl alcohol) hydrogels as potential tissue engineering scaffolds

Zhou, Yingshan; Zhao, Shuyan; Zhang, Can; Liang, Kaili; Li, Jun; Yang, Hongjun; Gu, Shaojin; Bai, Zikui; Ye, Dezhan; Xu, Weilin

doi:10.1016/j.carbpol.2018.01.009

Cited by 54 publications

(27 citation statements)

References 42 publications

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“…Zhou et al reported a photo-polymerized Thiol-enebased hydrogel for tissue engineering applications consisting of maleic chitosan, thiol-linked PVA and a biocompatible initiator. This hydrogel showed excellent mechanical properties and fibroblast cell compatibility [83]. Takemoto's group recently reported the crosslinking of hydrogels with live cells and tissues using azide-alkyne click chemistry reaction.…”

Section: Thiol-ene-based Click Hydrogels For Tissue Engineeringmentioning

confidence: 99%

Click Chemistry-Based Injectable Hydrogels and Bioprinting Inks for Tissue Engineering Applications

Janarthanan

Noh

2018

Tissue Eng Regen Med

120

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BACKGROUND: The tissue engineering and regenerative medicine approach require biomaterials which are biocompatible, easily reproducible in less time, biodegradable and should be able to generate complex three-dimensional (3D) structures to mimic the native tissue structures. Click chemistry offers the much-needed multifunctional hydrogel materials which are interesting biomaterials for the tissue engineering and bioprinting inks applications owing to their excellent ability to form hydrogels with printability instantly and to retain the live cells in their 3D network without losing the mechanical integrity even under swollen state. METHODS: In this review, we present the recent developments of in situ hydrogel in the field of click chemistry reported for the tissue engineering and 3D bioinks applications, by mainly covering the diverse types of click chemistry methods such as Diels-Alder reaction, strain-promoted azide-alkyne cycloaddition reactions, thiol-ene reactions, oxime reactions and other interrelated reactions, excluding enzyme-based reactions. RESULTS: The click chemistry-based hydrogels are formed spontaneously on mixing of reactive compounds and can encapsulate live cells with high viability for a long time. The recent works reported by combining the advantages of click chemistry and 3D bioprinting technology have shown to produce 3D tissue constructs with high resolution using biocompatible hydrogels as bioinks and in situ injectable forms. CONCLUSION: Interestingly, the emergence of click chemistry reactions in bioink synthesis for 3D bioprinting have shown the massive potential of these reaction methods in creating 3D tissue constructs. However, the limitations and challenges involved in the click chemistry reactions should be analyzed and bettered to be applied to tissue engineering and 3D bioinks. The future scope of these materials is promising, including their applications in in situ 3D bioprinting for tissue or organ regeneration.

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Section: Thiol-ene-based Click Hydrogels For Tissue Engineeringmentioning

confidence: 99%

Click Chemistry-Based Injectable Hydrogels and Bioprinting Inks for Tissue Engineering Applications

Janarthanan

Noh

2018

Tissue Eng Regen Med

120

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“…Tissue engineering is a technique for the reconstruction of organisms in assistance of the artificial cellular scaffolds that mimic extracellular matrix . Tissue engineering materials should intrinsically include nontoxicity, biocompatibility, and appropriate mechanical properties, creating functional and valuable tissues for regeneration purposes . These constructs can be cultured in vitro and then transplanted into the patient or allowed to grow into the patients' body by implanting a scaffold with cellular infiltration.…”

Section: Biomedical Applications Of Polysaccharides and Polysaccharidmentioning

confidence: 99%

Recent Progress of Polysaccharide‐Based Hydrogel Interfaces for Wound Healing and Tissue Engineering

Zhu

Mao

Cheng

et al. 2019

Adv Materials Inter

275

142

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Polysaccharide is an abundant and reproducible natural material that is biocompatible and biodegradable. Polysaccharide and its derivatives also possess distinctive properties such as hydrophilicity, mechanical stability, as well as tunable functionality. Polysaccharide‐based hydrogels can be constructed via the physical and/or chemical crosslinking of polysaccharide derivatives with different functional molecules, as porous network structures or nanofibrillar structures. This review discusses the biomedical applications of polysaccharide‐based hydrogels containing native polysaccharides, polysaccharide derivatives, and polysaccharide‐composite hydrogels. Recent works on the fabrication, physical properties, advanced engineering, biomedical applications of cellulose‐, chitosan‐, alginate‐, and starch‐based hydrogels are also elaborated. Such porous swelling scaffolds exhibit great advantages at the interface of a negative pressure system such as wound dressing. In addition, the authors also discuss and summarize the exemplary research works of these hydrogels in the applications of drug release, wound dressing, and tissue engineering. Finally, challenges and future perspectives about the development of polysaccharide‐based hydrogels are discussed.

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“…In thiol‐acrylate systems, acrylic vinyl monomer can significantly react with thiyl radical to undergo step growth polymerization, and meanwhile it can be homopolymerizated under UV irradiation . Based on this mechanism, methacrylamide CS/dithiothreitol hydrogel and maleilated CS/thiol‐terminated poly(vinyl alcohol) hydrogel are formed via photopolymerization technique, respectively.…”

Section: Photocrosslinking Processes Based On Photoactive Cs Macromersmentioning

confidence: 99%

Photocrosslinkable chitosan hydrogels and their biomedical applications

Pei

Mao

et al. 2018

J. Polym. Sci. Part A: Polym. Chem.

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Chitosan is a bioactive macromolecule with a wide variety of applications due to its excellent biological properties such as biodegradability, biocompatibility, and antibacterial activity, and so forth. This highlight focuses on the preparation of photoactive chitosans, the formation of photocrosslinkable chitosan hydrogels, and the related photopolymerization mechanisms. Moreover, the great potential applications of photocrosslinkable chitosan hydrogels for human tissues are also discussed. © 2018 Wiley Periodicals, Inc. J. Polym. Sci., Part A: Polym. Chem. 2019, 57, 1862–1871

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Photopolymerized maleilated chitosan/thiol-terminated poly (vinyl alcohol) hydrogels as potential tissue engineering scaffolds

Cited by 54 publications

References 42 publications

Click Chemistry-Based Injectable Hydrogels and Bioprinting Inks for Tissue Engineering Applications

Click Chemistry-Based Injectable Hydrogels and Bioprinting Inks for Tissue Engineering Applications

Recent Progress of Polysaccharide‐Based Hydrogel Interfaces for Wound Healing and Tissue Engineering

Photocrosslinkable chitosan hydrogels and their biomedical applications

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