Photopolymerized poly(l-lactide-b-N-vinyl-2-pyrrolidone) network resists cell adhesion in situ

Abstract

The poly(l-lactide-b-N-vinyl-2-pyrrolidone) network could be formed by UV curing, and resist the adhesion of L929 fibroblasts. It could be used in the field of biological anti-fouling material with customization requirements.

Preparation and characterization of photopolymerized poly(l-lactide-co-ε-caprolactone-co-N-vinyl-2-pyrrolidone) network as anti-biofouling materials

“…Three-armed poly( l -lactiede) prepolymer (3-PLLA) was prepared according to a previous reported. 7 Briefly, 3-PLLA was synthesized by using glycerol as an initiator to ring-open and polymerize l -lactide (LLA) ( Fig. 1A ).…”

“…The degree of polymerization of 3-PLLA in each arm has been calculated as 7.65 by 1 H-NMR according to the previous reported method. 7 As a result, the M w of 3-PLLA was about 3400 g mol À1 . By a GPC system the M n and polydispersity of 3-PLLA were determined as 4500 g mol À1 and 1.17, respectively.…”

“…In our previous work, a cross-linked network of functionalized poly(L-lactic) (PLLA) with NVP was developed for application in the eld of antifouling. 7 PLLA was conrmed to be non-toxic, low cost in use, good mechanical properties, biocompatible and biodegradable, thus has attracted much attention in the biomedical polymer eld. [8][9][10] Poly(N-vinyl-2-pyrrolidone) (PVP) possesses strong anti-biofouling capability and good biocompatibility, which has been used as a blood plasma substitute.…”