Photopromoted methoxycarbonylation of olefin with methyl formate by Co(OAc)2

Cui, Ying; Yin, Jing; Gao, Da Bin; Jia, Ying Ping; Zhou, Guang Yun; Li, Shen Min

doi:10.1016/j.cclet.2006.11.021

Cited by 5 publications

(1 citation statement)

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“…Methyl formate has shown diverse applications in carbonylation reactions, which is easy-handling, low toxic, and easy-to-transport. Metal-catalyzed hydroesterification of alkenes with alkyl or aryl formates, using rhodium, palladium, cobalt, or ruthenium has been identified to be an effective method. From the perspective of the reaction mechanism, there are two possible pathways by using formates as a C1 building block.…”

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confidence: 99%

Radical Esterification of Unactivated Alkenes Using Formate as Carbonyl Source

Xia

et al. 2022

J. Org. Chem.

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In recent years, methyl formate has received considerable attention as an ideal and green C1 building block to synthesize carboxylic esters. However, examples of a one-step route to esters with one-carbon elongation using methyl formate as a source of methoxycarbonyl radical are still rare. Herein, we present peroxide-induced radical carbonylation of N-(2-methylallyl)benzamides with methyl formate as the precursor of methoxycarbonyl radical and RuCl3 as catalyst, affording a series of biologically valuable 4-[(methoxycarbonyl)methyl]-3,4-dihydroisoquinolinones with good tolerance and insensitivity to moisture in one pot under simple and mild conditions.

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confidence: 99%