Photoprotective Antioxidant Phytochemicals

Deore, S. L.; Kombade, Saroj; Baviskar, Bhushan A; Khadabadi, S. S.

doi:10.7439/ijpp.v2i3.501

Cited by 13 publications

(11 citation statements)

References 18 publications

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“…Grapes (Vitis vinifera L) have 60-70% polyphenols [2]. Almost all polyphenols from nature are pigments usually yellow, purple or red, which are capable of absorbing ultraviolet (UV) radiation.…”

Section: Introductionmentioning

confidence: 99%

Total Phenol, Flavonoid Levels and IC50 in Local Grape (Vitis vinifera L) Skin Waste Wine

Maryam¹

2020

Proceedings of the Proceedings of the 7th Mathematics, Science, and Computer Science Education International Seminar, MSCEIS 20

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Grape skin is a waste produced from wine making derived from grapes. Currently the use of grape skins is still limited as a natural fertilizer. This research is study to determine the total levels of phenols, flavonoids both as antioxidants and IC50 in the grape skins from the waste of wine making. The study was determination quantitative of total phenolics with the folin-ciocalteu method expressed as mg of gallic acid equivalent (GAE), total flavonoids content by AlCl3 method expressed as Quercetin equivalen (QE) and antioxidant activity can be determined by using the DPPH test. The results stated that the total phenol, flavonoid and IC50 levels of grape skins were 168.55 (mg / 100gr) ; 61.10 (mg / 100 gr) and 1,065.19 ppm. The presence of total phenols, flavonoids and IC50 in grape skins is relatively high, so the use of grape skins from the process of making wine makes attention.

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Section: Introductionmentioning

confidence: 99%

Total Phenol, Flavonoid Levels and IC50 in Local Grape (Vitis vinifera L) Skin Waste Wine

Maryam¹

2020

Proceedings of the Proceedings of the 7th Mathematics, Science, and Computer Science Education International Seminar, MSCEIS 20

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“…On the other side, UV-B radiation is more genotoxic but less penetrating the skin than UV-A exerting its effects in epidermal skin layer inducing erythema, skin darkening, sunburns etc. [3], [5], [6]. More than 95 % of UV light reaching the Earth surface consists of UV-A rays (so called aging rays) [4], [7]- [9].…”

Section: Introductionmentioning

confidence: 99%

Bilirubin-Riboflavin Mutual Interaction in Methanol Under Continuous Uv Irradiation Regime

Stanojevic¹,

Cvetković²,

Zvezdanović³

et al. 2019

RAD Conference Proceedings

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The aim of the present study was to consider bilirubin (BRB) and riboflavin (RFL) mutual interaction in methanol solution under continuous UV-A and UV-B irradiation regime. Continuous irradiations of samples were performed in a cylindrical photochemical reactor "Rayonet", with 10 symmetrically placed lamps having the emission maximum at 300 nm (UV-B) and 350 nm (UV-A). The rate of BRB and RFL photodegradation along with simultaneous products formation, as a function of UV exposure time, was followed by combining UV-VIS absorption measurements with RP-HPLC analysis. The compounds were separated by gradient elution with mobile phase A (formic acid, 0.1% water solution) and B (formic acid, 0.1% methanol solution). According to the results obtained, BRB degradation in the absence of RFL was almost 22 times and 9 times slower in comparison to its degradation observed in BRB-RFL mixture under continuous UV-A and UV-B irradiation, respectively. Moreover, BRB degradation in BRB-RFL mixture under anaerobic conditions was almost 24 times and 16 times slower in comparison to the degradation in aerobic conditions under UV-A and UV-B light, respectively. The latter observation suggests that presence of ROS species contributes to UV-induced BRB degradation. These experiments provide the indirect proof of BRB acting as Type II sensitizer because of the fact that 1 O2 produced by RFL mediates BRB irreversible degradation giving rise to dipyrrole methanol adducts as typical products obtained via Type II mechanism.

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“…The primary objective of zero-order release is to up-hold constant drug concentration in blood for a prolonged period of time. Microspheres have played a vital role in the development of controlled/sustained release drug delivery systems [7][8]. Microspheres have been of particular interest from the pharmaceutical point of view providing the possibility to achieve sustained and controlled drug release.…”

Section: Introductionmentioning

confidence: 99%

Formulation and Evaluation of Indomethacin Microspheres using natural and synthetic polymers as Controlled Release Dosage Forms

B¹,

R²,

M³

et al. 2010

Int J of Drug Disc

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Abstract-Purpose: The aim of this study was to formulate and evaluate microspheres as controlled release preparations of a highly water-insoluble drug, Indomethacin, using natural polymer, Egg albumin; semi synthetic polymer, Ethyl cellulose and Synthetic polymer, Meth acrylic acid esters (Eudragit L 100) as the retardant materials. Methods: Microspheres were prepared by solvent evaporation method using an acetone / liquid paraffin system and Phase separation co-acervation method using petroleum ether and coconut oil as dispersion and continuous phase systems. Magnesium stearate was used as the droplet stabilizer and n-hexane was added to harden the microspheres. The prepared microspheres were evaluated for their micromeritic properties, drug content and encapsulation efficiency and characterized by Fourier transform infrared spectroscopy (FT-IR), and scanning electron microscopy (SEM). The in vitro release studies was performed by buffer change method to mimic Gas Intestine Tract(GIT) environment in pH 1.2, carbonate buffer (acidic) and pH 7.4, phosphate buffer (Alkaline). Results: The prepared microspheres were pale yellow, free flowing and spherical in shape. The mean particle size of the microspheres was found in the range of 150 to 400µm. The drug-loaded microspheres showed 70-86% of entrapment and release was extended up to 6 to 8 h releasing 86% of the total drug from the microspheres. The infrared spectra showed stable character of Indomethacin in the drug-loaded microspheres and revealed the absence of drug-polymer interactions. Scanning electron microscopy study revealed that the microspheres were spherical and porous in nature. Conclusion: The best-fit release kinetics was achieved with Koresmeyer-Peppas plot followed by zero order and First order. The release of Indomethacin was influenced by the drug to polymer ratio and particle size & was found to be both diffusion and dissolution controlled.

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Photoprotective Antioxidant Phytochemicals

Cited by 13 publications

References 18 publications

Total Phenol, Flavonoid Levels and IC50 in Local Grape (Vitis vinifera L) Skin Waste Wine

Total Phenol, Flavonoid Levels and IC50 in Local Grape (Vitis vinifera L) Skin Waste Wine

Bilirubin-Riboflavin Mutual Interaction in Methanol Under Continuous Uv Irradiation Regime

Formulation and Evaluation of Indomethacin Microspheres using natural and synthetic polymers as Controlled Release Dosage Forms

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