Photoprotective effect of 18β-glycyrrhetinic acid derivatives against ultra violet (UV)-B-Induced skin aging

Kumar, Amit; Sajida, Archo; Singh, Chetan Paul; Naikoo, Shahid Hussain; Singh, Buddh; Kaur, Sarabjit; Abdullah, Sheikh Tasduq

doi:10.1016/j.bmcl.2022.128984

Cited by 10 publications

(6 citation statements)

References 42 publications

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“…GA was isolated in bulk quantity from MeOH extract of stem bark of Glycyrrhiza glabra and characterized by spectroscopic techniques as reported previously. 6,7…”

Section: Methodsmentioning

confidence: 99%

“…GA was isolated in bulk quantity from MeOH extract of stem bark of Glycyrrhiza glabra and characterized by spectroscopic techniques as reported previously. 6,7 GA-O. To a solution of compound GA (5 g, 11 mmol) in DCM was added PCC (3.54 g, 16 mmol) dissolved in DCM dropwise till dark colour appears and kept it at RT for 2 h. Aer completion, reaction mixture was passed through Celite and ltrate was concentrated at rota vapour.…”

Section: Isolation Of 18b-glycyrrhetinic Acid (A01)mentioning

confidence: 99%

“…Some glycyrrhetinic acid derivatives have been reported for the protection of the skin damage from UV-B by inhibiting ROS generation, endoplasmic reticulum stress through MMP-1 pathway. 7 Recently, 18β-glycyrrhetinic acid mediated apoptosis has been reported in A549 lung cancer cells. 8 Based on these studies, the authors thought it worthwhile to investigate the anti-melanoma activity of indole fused 18β-glycyrrhetinic acid derivatives.…”

Section: Introductionmentioning

confidence: 99%

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Synthesis, molecular docking, and biological evaluation of [3,2-b]indole fused 18β-glycyrrhetinic acid derivatives against skin melanoma

et al. 2023

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“…GA was isolated in bulk quantity from MeOH extract of stem bark of Glycyrrhiza glabra and characterized by spectroscopic techniques as reported previously. 6,7…”

Section: Methodsmentioning

confidence: 99%

Section: Isolation Of 18b-glycyrrhetinic Acid (A01)mentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Synthesis, molecular docking, and biological evaluation of [3,2-b]indole fused 18β-glycyrrhetinic acid derivatives against skin melanoma

et al. 2023

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“…[26] GA also showed considerable efficacy to scavenge excess ROS, indicating the antioxidant property of GA, which was also reported in some other studies. [50,51] Both BG@N and B/BG@N effectively inhibited the overproduction of ROS in H 2 O 2 -treated NCTC-1469 cells, and B/BG@N exerted a superior ROS-scavenging efficacy. These results could be explained by the synergistic effect of BR and GA and the enhanced uptake of nanoparticle formulation.…”

Section: B/bg@n Protected Hepatocytes From Oxidative Stress Inflammat...mentioning

confidence: 99%

A Biomimetic Nanoparticle Exerting Protection against Acute Liver Failure by Suppressing CYP2E1 Activity and Scavenging Excessive ROS

Yao

Tang

Dai

et al. 2023

Adv Healthcare Materials

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Acute liver failure (ALF) is a severe liver disease caused by many reasons. One of them is the overdosed acetaminophen (APAP), which is metabolized into N‐acetyl‐p‐benzoquinone imine (NAPQI), an excessive toxic metabolite, by CYP2E1, resulting in excessive reactive oxygen species (ROS), exhausted glutathione (GSH), and thereafter hepatocyte necrosis. N‐acetylcysteine is the Food and Drug Administration‐approved drug for detoxification of APAP, but it has limited clinical application due to the short therapeutic time window and concentration‐related adverse effects. In this study, a carrier‐free and bilirubin dotted nanoparticle (B/BG@N) is developed, which is formed using bilirubin and 18β‐Glycyrrhetinic acid, and bovine serum albumin (BSA) is then adsorbed to mimic the in vivo behavior of the conjugated bilirubin for hitchhiking. The results demonstrate that B/BG@N can effectively reduce the production of NAPQI as well as exhibit antioxidant effects against intracellular oxidative stress via regulating the nuclear factor erythroid 2‐related factor 2/heme oxygenase‐1 signal axis and reducing the production of inflammatory factors. In vivo study shows that B/BG@N can effectively improve the clinical symptom of the mice model. This study suggests that B/BG@N own increases circulation half‐life, improves accumulation in the liver, and dual detoxification, providing a promising strategy for clinical ALF treatment.

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“…Eighteen β-Glycyrrhetinic acid derivatives can resist skin aging caused by UVB in doses of 10 and 25 µ M, possess good antioxidant activities [88], resist apoptosis, prevent collagen degradation, and significantly restore UVB-induced damage [89] AYAPE (Ala-Tyr-Ala-Pro-Glu) is a pentapeptide isolated from Isochrysis zhanjiangensis. The biological activity of AYAPE against skin aging was assessed using UVB-induced HaCat cells.…”

Section: Inhibiting Collagen Degradationmentioning

confidence: 99%

Research Progress in Skin Aging, Metabolism, and Related Products

He,

Gao,

Xie

2023

IJMS

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In recent years, skin aging has received increasing attention. Many factors affect skin aging, and research has shown that metabolism plays a vital role in skin aging, but there needs to be a more systematic review. This article reviews the interaction between skin metabolism and aging from the perspectives of glucose, protein, and lipid metabolism and explores relevant strategies for skin metabolism regulation. We found that skin aging affects the metabolism of three major substances, which are glucose, protein, and lipids, and the metabolism of the three major substances in the skin also affects the process of skin aging. Some drugs or compounds can regulate the metabolic disorders mentioned above to exert anti-aging effects. Currently, there are a variety of products, but most of them focus on improving skin collagen levels. Skin aging is closely related to metabolism, and they interact with each other. Regulating specific metabolic disorders in the skin is an important anti-aging strategy. Research and development have focused on improving collagen levels, while the regulation of other skin glycosylation and lipid disorders including key membrane or cytoskeleton proteins is relatively rare. Further research and development are expected.

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Photoprotective effect of 18β-glycyrrhetinic acid derivatives against ultra violet (UV)-B-Induced skin aging

Cited by 10 publications

References 42 publications

Synthesis, molecular docking, and biological evaluation of [3,2-b]indole fused 18β-glycyrrhetinic acid derivatives against skin melanoma

Synthesis, molecular docking, and biological evaluation of [3,2-b]indole fused 18β-glycyrrhetinic acid derivatives against skin melanoma

A Biomimetic Nanoparticle Exerting Protection against Acute Liver Failure by Suppressing CYP2E1 Activity and Scavenging Excessive ROS

Research Progress in Skin Aging, Metabolism, and Related Products

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