Photoprotective effect of solid lipid nanoparticles of rutin against UVB radiation damage on skin biopsies and tissue-engineered skin

Martins, Ronei Ximenes; de, Silvia; Martins, Siqueira; Barbosa, Gustavo Luis Ferreira; Fonseca, Maria José Vieira; Rochette, Patrick J.; Moulin, Véronique; Freitas, Luís

doi:10.1080/02652048.2022.2156631

Cited by 8 publications

(2 citation statements)

References 44 publications

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“…Martins and collaborators (2020) showed that the apple extract presented photoprotection in reconstructed skin model and normal skin explants, reversing the damage caused by UVB radiation. The ultraviolet radiation is responsible for various skin problems, such as premature skin aging, inflammatory processes and skin cancer (Martins et al, 2022;Martins et al, 2023). Therefore, its use as a natural compounds source is extremely important in the dermal formulation.…”

Section: Introductionmentioning

confidence: 99%

Apple pomace extract: photochemopreventive action against UVA radiation in a cell culture model

Martins,

Barbosa

et al. 2024

Cuad. Ed. Desar.

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Apple pomace, a byproduct from juice industry, can be used as a valuable nutraceutical, hence its phenolic compounds, including rutin, are powerful antioxidants. This work evidence the extract enriched with apple polyphenols from apple pomace using ethanol: water as solvent and partitioned with ethyl acetate (1:1 w/w), where its lyophilized product was evaluated for its photochemopreventive action on MRC-5 fibroblasts against a harmful UVA radiation dose. The enriched apple pomace extract was able to promote photochemopreventive action against UVA radiation, decreasing cell death and the lipid peroxidation formation. Therefore, the optimized extraction process may make the apple pomace application viable as a source of bioactive extracts with photochemopreventive action against ultraviolet radiation to the use in dermal formulations.

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Section: Introductionmentioning

confidence: 99%

Apple pomace extract: photochemopreventive action against UVA radiation in a cell culture model

Martins,

Barbosa

et al. 2024

Cuad. Ed. Desar.

Self Cite

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“…Furthermore, it is known that much of the skin damage caused by UV radiation is related to free radicals formed during to UV exposure [20][21][22][23][24][25]. Therefore, considering the antioxidant capacity of rutin, it is believed that it can confer additional protection from oxidative damage to the skin caused by sun exposure, justifying its application in multifunctional photoprotective formulations [26][27][28][29]. It is still worth highlighting that this bioactive compound is biocompatible, therefore, possessing a suitable profile to be used in cosmetic formulations [20,[30][31][32][33][34].…”

Section: Introductionmentioning

confidence: 99%

Would be Rutin a Feasible Strategy for Environmental-Friendly Photoprotective Samples? A Review from Stability to Skin Permeability and Efficacy in Sunscreen Systems

Ariede,

Gomez Junior,

Cândido

et al. 2024

Preprint

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Rutin, a flavonoid compound found in various plants, has gained attention for its potential applications in the cosmetic industry due to its antioxidant, anti-inflammatory, and potential photoprotective properties. Our review explored the use of rutin (rutoside, 3-O-rutinoside-quercetin) in cosmetics/dermocosmetics, focusing on its physicochemical properties and stability, cutaneous permeability, and efficacy in sunscreen systems, involving in vitro tests and the current state of clinical trials. Rutin's ability to scavenge free radicals, prevent peroxidation, and reduce vascular fragility makes this flavonoid a promising ingredient for photoprotection. Studies have shown that rutin can enhance the sun protection factor (SPF) of sunscreen formulations, especially when combined with organic UV filters. The encapsulation of rutin in nanostructures has also been investigated to improve its applicability. Overall, rutin shows potential as a safe and effective ingredient in cosmetic/dermocosmetic formulations, offering protection against the harmful effects of UV radiation and oxidative stress on the skin.

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Artemia salina Leach in photoprotection: A new model to evaluate the potential of nanoparticles for topical application

Gonçalo das Neves e Silva,

Ferreira Barbosa,

Alves Confessor

et al. 2023

Journal of Drug Delivery Science and Technology

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Photoprotective effect of solid lipid nanoparticles of rutin against UVB radiation damage on skin biopsies and tissue-engineered skin

Cited by 8 publications

References 44 publications

Apple pomace extract: photochemopreventive action against UVA radiation in a cell culture model

Apple pomace extract: photochemopreventive action against UVA radiation in a cell culture model

Would be Rutin a Feasible Strategy for Environmental-Friendly Photoprotective Samples? A Review from Stability to Skin Permeability and Efficacy in Sunscreen Systems

Artemia salina Leach in photoprotection: A new model to evaluate the potential of nanoparticles for topical application

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