Photoprotective effects of topical ginseng leaf extract using Ultraflo L against UVB-induced skin damage in hairless mice

Hong, Yang; Lee, Hyun Sun; Jung, Eun Young; Han, Sung Hee; Park, Yooheon; Suh, Hyung Joo

doi:10.1016/j.jgr.2016.07.007

Cited by 23 publications

(12 citation statements)

References 36 publications

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“…Within the ECM, the major structural proteins are collagen and elastin, and proteolytic enzymes, such as MMPs and elastases, which are produced by epidermal keratinocytes and fibroblasts, mediate the remodeling of ECM. UVB irradiation has been reported to alter the signal transduction pathways that promote the expression of MMP and elastase and decrease the synthesis of procollagen [ 29 , 30 ]. MMP-9, which is a gelatinase, degrades both collagen fragments generated by other collagenases and elastic fibers [ 28 ], and IL-1β, besides affecting endothelial cells, is reported to increase the expression of MMP-9 in murine macrophages [ 31 ].…”

Section: Discussionmentioning

confidence: 99%

Oral administration of Jumihaidokuto inhibits UVB-induced skin damage and prostaglandin E2 production in HR-1 hairless mice

Murata¹,

Oyama²,

Ogata³

et al. 2020

J Nat Med

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This study was conducted to investigate whether and how Jumihaidokuto (JHT), a traditional Chinese medicine, prevents UVB-induced skin damage in male HR-1 hairless mice. JHT has been traditionally prescribed for patients presenting skin disorders with redness and swelling, and, in Japan, it is approved for prescription to patients with acute and/or purulent skin disorders, hives, acute eczema, and athlete’s foot. Considering the traditional use of JHT, we hypothesized that oral administration of JHT might emerge as an effective strategy to prevent UVB-induced skin damage, such as edema and erythema. Here, we pretreated mice with JHT (1000 mg/kg, p.o.) for 3 weeks and then administered a single dose of UVB irradiation (250 mJ/cm2) on the dorsal skin. UVB irradiation increased the erythema index and transepidermal water loss (TEWL) and decreased the skin water content in the epidermis at 72 h post-irradiation. JHT treatment inhibited the increase of TEWL and the loss of water content in the epidermis, but not the elevation of the erythema index. Moreover, administration of JHT suppressed UVB-induced epidermal hyperplasia by blocking the proliferation of keratinocytes and also inhibited irradiation-triggered reduction of collagen fibers and infiltration of immune cells into the dermis. Lastly, administration of JHT suppressed UVB-induced production of proinflammatory mediators, such as prostaglandin E2 and interleukin-1β. These results suggest that JHT prevents UVB-induced skin damage and that the underlying mechanism involves the inhibition of proinflammatory mediators.

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Section: Discussionmentioning

confidence: 99%

Oral administration of Jumihaidokuto inhibits UVB-induced skin damage and prostaglandin E2 production in HR-1 hairless mice

Murata¹,

Oyama²,

Ogata³

et al. 2020

J Nat Med

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“…Its antiviral property against gamma herpesvirus[5] and photochemoprotective activities against ultraviolet rays affecting the skin were studied recently. [6]…”

Section: Discussionmentioning

confidence: 99%

Comparison of the efficacy of herbal mouth rinse with commercially available mouth rinses: A clinical trial

Jeddy

Ravi

Radhika

et al. 2018

J Oral Maxillofac Pathol

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Aim: The aim of the study was to compare the efficacy of an herbal mouthwash containing red ginseng extract with different brands of commercially available chemical mouthwashes. Objective: The objective of the study was to evaluate the effectiveness of herbal mouthwash (Dr. Dental care liquid) in reducing the oral bacterial count and compare it with the efficacy of commercially available mouthwashes such as Rexidine, Listerine and Colgate Plax. Materials and Methods: The study includes sixty normal individuals (aged 18–24 years) who were divided into four groups of 15 individuals each. The participants of each group were given four different mouthwashes (Dr. Dental Care liquid, Colgate Plax, Listerine and Rexidine) and asked to use it twice daily for 5 days. Saliva samples were collected before the use of mouthwash and also after 5 days of using the mouthwashes. Culture and microscopic examination of salivary samples was done, and oral bacterial load present in the saliva samples was counted before and after the mouth rinse use. Results: The results were compared using Wilcoxon sign-rank test. Among the four mouthwashes, the herbal mouthwash, Dr. Dental care liquid exhibited maximum efficacy in reducing the amount of bacteria followed by Colgate Plax, Listerine and Rexidine. Conclusion: The herbal mouthwash, Dr. Dental care liquid, contains red ginseng extract, a herb with immense medicinal values. In this study, the herbal mouth rinse exhibited increased antibacterial action compared with other commercially available chemical mouth rinses. Hence, we conclude that the ginseng-containing herbal mouthwash can be considered as a safe and effective oral hygiene aid.

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“…Dammarane ginsenosides are considered to play a major role in the antiwrinkle activities of ginseng. These compounds are strongly linked with cellulose, pectin, or β-glucan [159]. Jesenak et.al, 2016 investigated the immunomodulatory and anti-inflammatory activity of an Imunoglukan P4H ® cream, containing β-glucans (pleuran), in patients suffering from atopic dermatitis, where use of β-glucanbased cream as a supportive complementary therapy [161].…”

Section: G α-Lipoic Acidmentioning

confidence: 99%

Skin Aging & Modern Age Anti-aging Strategies

Mohiuddin¹

2019

GJMR

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As the most voluminous organ of the body that is exposed to the outer environment, the skin suffers from both intrinsic and extrinsic aging factors. Skin aging is characterized by features such as wrinkling, loss of elasticity, laxity, and rough-textured appearance. This aging process is accompanied with phenotypic changes in cutaneous cells as well as structural and functional changes in extracellular matrix components such as collagens and elastin. With intrinsic aging, structural changes occur in the skin as a natural consequence of the biological changes over time and produce a certain number of histological, physiological, and biochemical modifications. Intrinsic aging is determined genetically (influence of gender and ethnic group), variable in function of skin site, and also influenced by hormonal changes. Visually it is characterized by fine wrinkles. By comparison, “photoaging” is the term used to describe the changes occurring in the skin, resulting from repetitive exposure to sunlight. The histological, physiological, and biochemical changes in the different layers of the skin are much more drastic. From a mechanical point of view, human skin appears as a layered composite containing the stiff thin cover layer presented by the stratum corneum, below which are the more compliant layers of viable epidermis and dermis and further below the much more compliant adjacent layer of subcutaneous white adipose tissue.

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Photoprotective effects of topical ginseng leaf extract using Ultraflo L against UVB-induced skin damage in hairless mice

Cited by 23 publications

References 36 publications

Oral administration of Jumihaidokuto inhibits UVB-induced skin damage and prostaglandin E2 production in HR-1 hairless mice

Oral administration of Jumihaidokuto inhibits UVB-induced skin damage and prostaglandin E2 production in HR-1 hairless mice

Comparison of the efficacy of herbal mouth rinse with commercially available mouth rinses: A clinical trial

Skin Aging & Modern Age Anti-aging Strategies

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