Photoprotective Potential of <i>Baccharis antioquensis</i> (Asteraceae) as Natural Sunscreen

Mejía-Giraldo, Juan C.; Winkler, Robert; Gallardo, Cécilia; Sánchez-Zapata, Ana M.; Puertas‐Mejía, Miguel A.

doi:10.1111/php.12619

Cited by 31 publications

(34 citation statements)

References 44 publications

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“…The very first attempts to substitute synthetic sunscreens with the natural ones, for example, leaf extracts of Baccharis antioquensis containing quercetin, kaempferol, and caffeic acid glycosides [77] have been conducted. It has been published recently [23] that the glycosylated plant phenylpropanoids (polyphenols) baicalein and verbascoside protected cultured human keratinocytes against a broad band UVA + UBV simulating solar UV irradiation better than benzophenone-3.…”

Section: Pre-selection Of Sun-protective Secondary Plant Metabolitesmentioning

confidence: 99%

Secondary Plant Metabolites for Sun Protective Cosmetics: From Pre-Selection to Product Formulation

Korkina¹,

Kostyuk

Potapovich

et al. 2018

Cosmetics

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Topical sun protective cosmetics (sunscreens, pre-and post-sun) have been intensively developed and produced to protect human skin against solar irradiation-associated damages/pathologies. Unfortunately, routine cosmetics for sun protection containing synthetic organic and/or physical sunscreens could exert adverse effects towards human organisms and bring undesirable ecological changes. Terrestrial and marine plant species, being exposed to sun light for hundreds of millions of years, have evolved two pro-survival strategies: effective protection against/adaptation to its deleterious effects and the use of solar energy for photosynthesis/photo-biochemical reactions. Secondary plant metabolites (SPM) are primary sensors of solar energy and mediators of its use (photo-sensitisers) or neutralisation (photo-protectors). A similar double photo-protective/photo-sensitising system is built in within human skin. Modern development of toxicologically/ecologically safe yet effective sun-protective cosmetics attempts to pre-select photo-stable and non-phototoxic SPMs that provide broad UVA + UVB sunscreen, free radical scavenging and direct antioxidant defence, endogenous antioxidant rescue, induction of antioxidant enzymes (indirect antioxidant defence), and normalisation of metabolic and immune responses to UVA + UVB. Proper formulation of sun protective cosmetics should assure targeted delivery of photo-active SPMs to definite skin layers to invigorate the built in photo-chemical skin barrier.

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Section: Pre-selection Of Sun-protective Secondary Plant Metabolitesmentioning

confidence: 99%

Secondary Plant Metabolites for Sun Protective Cosmetics: From Pre-Selection to Product Formulation

Korkina¹,

Kostyuk

Potapovich

et al. 2018

Cosmetics

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“…There have been the very first attempts to substitute synthetic sunscreens with the natural ones, for example, leaf extracts of Baccharis antioquensis containing quercetin, kaempferol, and caffeic acid glycosides. 31 In this study, we observed that capacity of different polyphenols to physical absorption of UVB+UVA light (screening effect) closely related to protection of HaCaT cells from UV-induced cell death ( Table 3 ). To our astonishment, similar molar concentrations (50 μM) of benzophenone-3 and plant polyphenols, such as verbascoside and baicalein, in the cultural medium layer over Petri dish bottom, where cellular monolayer was attached, had strikingly different transmission of UVA+UVB and protection against cellular death.…”

Section: Discussionmentioning

confidence: 66%

Natural Substances for Prevention of Skin Photoaging: Screening Systems in the Development of Sunscreen and Rejuvenation Cosmetics

Kostyuk

Potapovich

Albuhaydar

et al. 2018

Rejuvenation Research

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Solar broadband UV irradiation is commonly regarded as a major causative reason for cutaneous photoaging. The pro-aging molecular pathways and cellular targets affected by UVA+UVB light in human skin have been extensively investigated. Notwithstanding growing knowledge in mechanisms of photoaging, research and development of clinically efficient, nontoxic, and sustainable topical preparations providing full physical, chemical, and biological photoprotection still remain a great challenge for pharmaceutical and cosmetic industries. In this study, we are proposing a panel of the in vitro methods for preselection of natural photoprotective substances with high photostability and low phototoxicity able of absorbing a broadband UVA+UVB irradiation (physical sunscreen), reducing UV-related overproduction of free radicals and loss of endogenous antioxidants (chemical protection), and attenuating UV-induced cytotoxicity and immune and metabolic responses (biological protection) in primary human epidermal keratinocytes and immortalized human keratinocyte cultures. Our data showed that secondary metabolites biosynthesized in plant cells in response to UV irradiation, such as phenylpropanoids and their glycosylated metabolites, aglycons and glycosylated flavonoids, and leontopodic acids, hold the best promise for complete natural topical prevention of photoaging and rejuvenation of photoaged skin. Meristem plant cell cultures elicited by solar simulating UV could be the most environmentally sustainable biotechnological source of polyphenols with combined photoprotective and antiaging properties.

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“…In congruence, we observed that amino acids and isoflavones were abundant in Fabaceae, while the kaempferol and quercetin derivatives were relatively higher in Asteraceae and Rosaceae family extracts, respectively. Reportedly, the kaempferol glycosides are the main polyphenolic compounds in Asteraceae family plants [22]. Whereas, quercetin glycosides are the typical flavonol glycoside in the Rosaceae family, along with flavan-3-ol (catechin and epicatechin) and polyphenol compounds, including ellagic acid [23].…”

Section: Discussionmentioning

confidence: 99%

Exploring the metabolomic diversity of plant species across spatial (leaf and stem) components and phylogenic groups

Lee

Singh

et al. 2020

BMC Plant Biol

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Background: Plants have been used as an important source of indispensable bioactive compounds in various cosmetics, foods, and medicines. However, the subsequent functional annotation of these compounds seems arduous because of the largely uncharacterized, vast metabolic repertoire of plant species with known biological phenotypes. Hence, a rapid multi-parallel screening and characterization approach is needed for plant functional metabolites. Results: Fifty-one species representing three plant families, namely Asteraceae, Fabaceae, and Rosaceae, were subjected to metabolite profiling using gas chromatography time-of-flight mass spectrometry (GC-TOF-MS) and ultrahigh-performance liquid chromatography quadrupole orbitrap ion trap tandem mass spectrometry (UHPLC-Qorbitrap-MS/MS) as well as multivariate analyses. Partial least squares discriminant analysis (PLS-DA) of the metabolite profiling datasets indicated a distinct clustered pattern for 51 species depending on plant parts (leaves and stems) and relative phylogeny. Examination of their relative metabolite contents showed that the extracts from Fabaceae plants were abundant in amino acids, fatty acids, and genistein compounds. However, the extracts from Rosaceae had higher levels of catechin and ellagic acid derivatives, whereas those from Asteraceae were higher in kaempferol derivatives and organic acids. Regardless of the different families, aromatic amino acids, branch chain amino acids, chlorogenic acid, flavonoids, and phenylpropanoids related to the shikimate pathway were abundant in leaves. Alternatively, certain amino acids (proline, lysine, and arginine) as well as fatty acids levels were higher in stem extracts. Further, we investigated the associated phenotypes, i.e., antioxidant activities, affected by the observed spatial (leaves and stem) and intra-family metabolomic disparity in the plant extracts. Pearson's correlation analysis indicated that ellagic acid, mannitol, catechin, epicatechin, and quercetin derivatives were positively correlated with antioxidant phenotypes, whereas eriodictyol was positively correlated with tyrosinase inhibition activity. Conclusions: This work suggests that metabolite profiling, including multi-parallel approaches and integrated bioassays, may help the expeditious characterization of plant-derived metabolites while simultaneously unraveling their chemodiversity.

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Photoprotective Potential of Baccharis antioquensis (Asteraceae) as Natural Sunscreen

Cited by 31 publications

References 44 publications

Secondary Plant Metabolites for Sun Protective Cosmetics: From Pre-Selection to Product Formulation

Secondary Plant Metabolites for Sun Protective Cosmetics: From Pre-Selection to Product Formulation

Natural Substances for Prevention of Skin Photoaging: Screening Systems in the Development of Sunscreen and Rejuvenation Cosmetics

Exploring the metabolomic diversity of plant species across spatial (leaf and stem) components and phylogenic groups

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