Photoreceptor integrity and visual acuity in cystoid macular oedema associated with retinitis pigmentosa

Abstract

Aims To assess the correlation between macular morphology and visual acuity in retinitis pigmentosa (RP) patients with cystoid macular oedema (CME). Design Retrospective cross-sectional study. Patients and methods Forty-one eyes of 25 RP patients with CME. Patients underwent cross-sectional scans with optical coherence tomography (Stratus OCT). Age, total retinal thickness, photoreceptor thickness, and the transverse and vertical lengths of the cystoid space were measured. Correlation between visual acuity and each of the measurements were examined. Additionally, the status of the inner segment/outer segment junction (IS/OS) was classified as being absent, discontinuous, or distinct. Measurements were then compared among the three groups. Results Total retinal thickness or photoreceptor thickness was not correlated with visual acuity. There was a correlation between the transverse length of the cystoid space and visual acuity, although the correlation coefficient was weak (r ¼ 0.30). The logMAR visual acuity in the IS/OS absent group (0.67±0.43) was worse than that seen in the IS/OS discontinuous (0.22 ± 0.19) or IS/OS distinct groups (0.07 ± 0.16) (Po0.001). Conclusions When monitoring CME associated with RP, the status of IS/OS is the essential parameter that needs to be examined.

Comparison of Topical Dorzolamide and Ketorolac Treatment for Cystoid Macular Edema in Retinitis Pigmentosa and Usher's Syndrome

“…Other authors described similar observations [31,32,33]. Again, retinal atrophic changes, photoreceptor layer integrity [47] and possibly macular cyst characteristics (morphology, size and distribution in the macula) might explain this correlation.…”

“…Our results concerning the dorzolamide effect on retinal thickness are clearly worse when compared with other studies [10,31,32]. Photoreceptor layer integrity [47] and a long-standing CME with atrophic changes of the neurosensory retina might explain this difference. An OCT qualitative analysis could therefore bring value, enlightening and possibly explaining our results.…”

Qualitative and quantitative OCT response of diffuse diabetic macular oedema to macular laser photocoagulation

“…This study showed that eyes with absent or disrupted HRB at baseline had a poorer visual outcome compared with eyes with intact HRB, supporting previous observations that the HRB layer is a valid OCTderived surrogate marker for visual function in DMO and many other retinal diseases. [33][34][35][36][37][38][39] This study reverberates several recent reports that emphasised the correlation of an intact HRB layer with better VA in DMO as well as other retinal diseases.…”

Geographic pattern of central retinal sensitivity after intravitreal triamcinolone for diabetic macular edema

“…[1][2][3][4][5][6] In the present study, VA was significantly better in the IS/OS(+) group than in the IS/ OS(−) group at 1 month postoperatively. In addition, retinal sensitivity at 2°, which correspond to 500 μm from the center of the fovea, was also better in the IS/OS(+) group than in the IS/OS(−) group.…”