Photoredox-catalyzed hydroxymethylation of β-ketoesters: application to the synthesis of [3.3.3] propellane lactones

Abstract

Photoredox-catalysed hydroxymethylation of -ketoesters substituted by an allyl subunit on the -position afforded directly the corresponding bicyclic lactones possessing both a hydroxy group and an unsaturation. A subsequent regioselective iodoetherification...

Access to Hexahydroindeno[2,1-c]pyran-Based Propellanes by a Domino Prins/Friedel–Crafts Cyclization

“…[32][33][34] Moreover, we recently described access to propellane derivatives from easily available bicyclic hydroxylactones. 35,36 Herein, we report the synthesis of a new class of propellanes that contain a hexahydroindeno[2,1-c]pyran subunit by starting from unsaturated alcohols.…”