Photoresponsive Coumarin-Tethered Multifunctional Magnetic Nanoparticles for Release of Anticancer Drug

Abstract

Recently, photoresponsive nanoparticles have received significant attention because of their ability to provide spatial and temporal control over the drug release. In the present work, we report for the first time photoresponsive multifunctional magnetic nanoparticles (MNPs) fabricated using coumarin-based phototrigger and Fe/Si MNPs for controlled delivery of anticancer drug chlorambucil. Further, newly fabricated photoresponsive multifunctional MNPs were also explored for cell luminescence imaging. In vitro biological studies revealed that coumarin tethered Fe/Si MNPs of ~9 nm size efficiently delivered the anticancer drug chlorambucil into cancer cells and thereby improving the drug action to kill the cancer cells upon irradiation. Such multifunctional MNPs with strong fluorescence, good biocompatibility and efficient photocontrolled drug release ability will be of great benefit in the construction of light-activated multifunctional nano drug delivery systems.

Targeted photoresponsive TiO2–coumarin nanoconjugate for efficient combination therapy in MDA-MB-231 breast cancer cells: synergic effect of photodynamic therapy (PDT) and anticancer drug chlorambucil

“…The instrumental details and experimental procedure are explained in the ESI † (section 3.1.(iv)). 23 Following treatment for 24 and 48 h at 37°C, MTT solution (5 mg ml −1 in PBS) was added and incubation was prolonged for 5 h at 37°C. Inhibition of cell proliferation was monitored by MTT (Himedia) assay.…”

Recent Advances of Light-Mediated Theranostics

“…In the last decades, various photocaged molecules, such as o-nitrobenzyl (ONB) 40-42, pyrenylmethyl ester 43 and coumarinyl ester 44, 45, etc (Figure 2A), have been established for spatiotemporally regulating bimolecular activities, real-time monitoring cell trafficking and controlled release of therapeutic molecules in vitro and in vivo . For instance, Xing and co-workers synthesized a set of stable and efficient photoactivable D-luciferin probe molecules to real-time image firefly luciferase (fLuc) bioluminescence reporter in vitro and in vivo (Figure 2B) 46.…”

pH-Sensitive Nanoaggregates for Site-Specific Drug-Delivery as Well as Cancer Cell Imaging

“…13 A dialysis bag containing a water solution of the final copolymer (5 mg/mL) was placed in a 50 mL beaker. The solution of the copolymer (Nor–Chl–Py–Btn) was dialyzed against a phosphate-buffered saline/acetonitrile 27 (95:5) mixture (pH = 5.5) to mimic the cancer cell pH. The absorbance of the buffer was measured at different time intervals up to 24 h.…”