Photoresponsive Crosslinked Hyperbranched Polyglycerols as Smart Nanocarriers for Guest Binding and Controlled Release

Burakowska, Ewelina; Zimmerman, Steven C.; Haag, Rainer

doi:10.1002/smll.200900465

Cited by 58 publications

(30 citation statements)

References 28 publications

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“…[181] The photodegradable nanocapsules retained the capacity and selectivity for encapsulating bioactive The light-triggered release of rose bengal from the dye complex in chloroform was confirmed by irradiation of the solution at 350 nm monochromatic light. Figure 38 shows the controlled release of the dye as a function of UV irradiation time.…”

Section: Non-aqueous Encapsulation Systemsmentioning

confidence: 86%

Dendritic Polyglycerols for Biomedical Applications

et al. 2009

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The application of nanotechnology in medicine and pharmaceuticals is a rapidly advancing field that is quickly gaining acceptance and recognition as an independent area of research called "nanomedicine". Urgent needs in this field, however, are biocompatible and bioactive materials for antifouling surfaces and nanoparticles for drug delivery. Therefore, extensive attention has been given to the design and development of new macromolecular structures. Among the various polymeric architectures, dendritic ("treelike") polymers have experienced an exponential development due to their highly branched, multifunctional, and well-defined structures. This Review describes the diverse syntheses and biomedical applications of dendritic polyglycerols (PGs). These polymers exhibit good chemical stability and inertness under biological conditions and are highly biocompatible. Oligoglycerols and their fatty acid esters are FDA-approved and are already being used in a variety of consumer applications, e.g., cosmetics and toiletries, food industries, cleaning and softening agents, pharmaceuticals, polymers and polymer additives, printing photographing materials, and electronics. Herein, we present the current status of dendritic PGs as functional dendritic architectures with particular focus on their application in nanomedicine, in drug, dye, and gene delivery, as well as in regenerative medicine in the form of non-fouling surfaces and matrix materials.

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Section: Non-aqueous Encapsulation Systemsmentioning

confidence: 86%

Dendritic Polyglycerols for Biomedical Applications

et al. 2009

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“…The molecular size of a dendrimer with azobenzene derivatives depends on the photo-and heatisomerization abilities of the azobenzene unit. The photoresponse can also be obtained by introducing O-nitrobenzyl groups to the surface of hyperbranched polyglycerols (HPGs) for drug release [86]. The presence of a hexa(ethylene glycol) outer-shell instead of the hexene increased the stability of the formed host-guest complexes but resulted in lower guest release.…”

Section: Photo-responsive Dendrimersmentioning

confidence: 99%

Stimuli-Responsive Polymers and Their Applications in Nanomedicine

et al. 2012

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This review focuses on smart nano-materials built of stimuli-responsive (SR) polymers and will discuss their numerous applications in the biomedical field. The authors will first provide an overview of different stimuli and their corresponding, responsive polymers. By introducing myriad functionalities, SR polymers present a wide range of possibilities in the design of stimuli-responsive devices, making use of virtually all types of polymer constructs, from self-assembled structures (micelles, vesicles) to surfaces (polymer brushes, films) as described in the second section of the review. In the last section of this review the authors report on some of the most promising applications of stimuli-responsive polymers in nanomedicine. In particular, we will discuss applications pertaining to diagnosis, where SR polymers are used to construct sensors capable of selective recognition and quantification of analytes and physical variables, as well as imaging devices. We will also highlight some examples of responsive systems used for therapeutic applications, including smart drug delivery systems (micelles, vesicles, dendrimers...) and surfaces for regenerative medicine.

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“…When exposed to ultrasound, these bioerodible polymers respond rapidly and reversibly. It is believed that the ultrasound also causes an increase in temperature in the delivery system, which allows the diffusion [88,89]. ULS-responsive polymers are advantageous because they are non-invasive and capable of penetrating deep into the interior of the body and thus drug delivery can be focused and carefully controlled through a number of parameters including frequency, power density, duty cycles and time of application [90,91].…”

Section: Ultrasonically Responsive Polymersmentioning

confidence: 99%

Drug Delivery Systems: Smart Polymeric Materials

Cassano

Trombino

2014

Advanced Polymers in Medicine

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Over the last two decades the smart polymeric materials have involved the interest of the scientific community because they can be used in the design and formulation of dosage forms that respond, with a considerable variation of their properties, to changes in their environment. As result, these materials control the drug release into specific physiological compartments. Concerning on the environmental stimuli these include pH, temperature, light, chemicals, etc. The smart polymeric materials stimuli-responsive can be synthetics or naturals and have been used in the biotechnological, medicinal and engineering fields. The present chapter is aimed to focus the importance of this category of drug delivery systems and, in particular, it provides a summarizing overview of the range of smart polymeric materials and the drug delivery systems that exploit them.

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Photoresponsive Crosslinked Hyperbranched Polyglycerols as Smart Nanocarriers for Guest Binding and Controlled Release

Cited by 58 publications

References 28 publications

Dendritic Polyglycerols for Biomedical Applications

Dendritic Polyglycerols for Biomedical Applications

Stimuli-Responsive Polymers and Their Applications in Nanomedicine

Drug Delivery Systems: Smart Polymeric Materials

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