Photoresponsive Hydrogels as Drug Delivery Systems

Abueva, Celine; Chung, Phil‐Sang; Ryu, Hyun Seok; Park, Soyoung; Woo, Seung Hoon

doi:10.25289/ml.2020.9.1.6

Cited by 8 publications

(5 citation statements)

References 41 publications

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“…Photoresponsive supramolecular hydrogels are emerging smart materials 1,2 with prospective applications in drug delivery [3][4][5][6] or regenerative medicine. [7][8][9] They are formed from hydrogelators, oen based on sugars or oligopeptides, which self-assemble in water.…”

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confidence: 99%

Reversible photodissipation of composite photochromic azobenzene-alginate supramolecular hydrogels

et al. 2022

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confidence: 99%

Reversible photodissipation of composite photochromic azobenzene-alginate supramolecular hydrogels

et al. 2022

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“…In addition, NIR, without being strongly absorbed by body fluid, presents better tissue transparency than other wavelengths and is an ideal candidate for designing light-responsive in situ hydrogels ( Raza et al, 2019 ). Thus, many injectable hydrogel systems have been explored to construct an in situ hydrogel in niduses via an NIR light trigger due to its noninvasive nature, high spatial resolution, temporal control, and convenience ( Abueva et al, 2020 ) ( Figure 5 ).…”

Section: Application Of Exogenous Stimulus-responsive In Si...mentioning

confidence: 99%

Smart responsive in situ hydrogel systems applied in bone tissue engineering

Wu,

Gai,

Chen

et al. 2024

Front. Bioeng. Biotechnol.

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The repair of irregular bone tissue suffers severe clinical problems due to the scarcity of an appropriate therapeutic carrier that can match dynamic and complex bone damage. Fortunately, stimuli-responsive in situ hydrogel systems that are triggered by a special microenvironment could be an ideal method of regenerating bone tissue because of the injectability, in situ gelatin, and spatiotemporally tunable drug release. Herein, we introduce the two main stimulus-response approaches, exogenous and endogenous, to forming in situ hydrogels in bone tissue engineering. First, we summarize specific and distinct responses to an extensive range of external stimuli (e.g., ultraviolet, near-infrared, ultrasound, etc.) to form in situ hydrogels created from biocompatible materials modified by various functional groups or hybrid functional nanoparticles. Furthermore, “smart” hydrogels, which respond to endogenous physiological or environmental stimuli (e.g., temperature, pH, enzyme, etc.), can achieve in situ gelation by one injection in vivo without additional intervention. Moreover, the mild chemistry response-mediated in situ hydrogel systems also offer fascinating prospects in bone tissue engineering, such as a Diels–Alder, Michael addition, thiol-Michael addition, and Schiff reactions, etc. The recent developments and challenges of various smart in situ hydrogels and their application to drug administration and bone tissue engineering are discussed in this review. It is anticipated that advanced strategies and innovative ideas of in situ hydrogels will be exploited in the clinical field and increase the quality of life for patients with bone damage.

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“…Electrosensitive hydrogels are commonly polymer mixtures or co-networks of conductive polymers and highly hydrophilic hydrogels that respond to electrical stimuli. 87 The electroactive component is responsible for conductance and on-off opticelectronic switch, whereas the hydration component is responsible for expansion, cytocompatibility, and tiny molecular diffusion. 89,90 A current gradient is maintained when a liquid covalently bonded polyelectrolyte gel is placed over two electrodes and exposed to DC power.…”

Section: Electrically Conductive Hydrogelsmentioning

confidence: 99%