Photoresponsive real time monitoring silicon quantum dots for regulated delivery of anticancer drugs

Paul, Amrita; Jana, Avijit; Karthik, S.; Bera, Manoranjan; Zhao, Yanli; Singh, N. D. Pradeep

doi:10.1039/c5tb02045j

Cited by 50 publications

(25 citation statements)

References 32 publications

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“…Recently, photoresponsive theranostic DDSs have attracted enormous interest because they allow precise control over drug release, including location, timing, and dosage through an active ingredient “phototrigger”. A number of photoresponsive DDSs have been developed that employ o ‐nitrobenzyl, coumarinyl, perylene and acetyl carbazole derivatives as phototriggers for efficient drug or gene delivery.…”

Section: Methodsmentioning

confidence: 99%

Three‐Arm, Biotin‐Tagged Carbazole–Dicyanovinyl–Chlorambucil Conjugate: Simultaneous Tumor Targeting, Sensing, and Photoresponsive Anticancer Drug Delivery

Venkatesh

Karthik

Rajesh

et al. 2016

Chemistry An Asian Journal

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The design, synthesis, and in vitro biological studies of a biotin-carbazole-dicyanovinyl-chlorambucil conjugate (Bio-CBZ-DCV-CBL; 6) are reported. This conjugate (6) is a multifunctional single-molecule appliance composed of a thiol-sensor DCV functionality, a CBZ-derived phototrigger as well as fluorescent reporter, and CBL as the anticancer drug, and Bio as the cancer-targeting ligand. In conjugate 6, the DCV bond undergoes a thiol-ene click reaction at pH<7 with intracellular thiols, thereby shutting down internal charge transfer between the donor CBZ and acceptor DCV units, resulting in a change of the fluorescence color from green to blue, and thereby, sensing the tumor microenvironment. Subsequent photoirradiation results in release of the anticancer drug CBL in a controlled manner.

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Section: Methodsmentioning

confidence: 99%

Three‐Arm, Biotin‐Tagged Carbazole–Dicyanovinyl–Chlorambucil Conjugate: Simultaneous Tumor Targeting, Sensing, and Photoresponsive Anticancer Drug Delivery

Venkatesh

Karthik

Rajesh

et al. 2016

Chemistry An Asian Journal

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“…This approach would be related to, but different from other promising approaches on quantum dot-based bioconjugates, reported recently. [70][71][72][73] With this motivation, a proof of principle study has been performed using HSA-bound warfarin, in presence and absence of MPA-capped CdSe nanotetrapods. The goal of this experiment is to ascertain if the secondary structure of HSA is disrupted in the presence of nanotetrapods or not.…”

Section: Resultsmentioning

confidence: 99%

Release of Warfarin from Human Serum Albumin by Water‐soluble CdSe Nanotetrapods

et al. 2020

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Water soluble CdSe nanotetrapods are prepared by ligand exchange from organic‐soluble ones. In order to achieve this, oleic acid, which is the capping agent for as prepared water‐insoluble nanotetrapods, is exchanged with mercaptopropanoic acid (MPA). Shape and size of nanotetrapods are conserved upon ligand exchange. Ground state bleach recovery dynamics remain the same as well. However, they are completely non‐emissive. These water‐soluble nanotetrapods disrupt the secondary structure of Human Serum Albumin (HSA) and consequently, release warfarin bound to the protein.

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“…Upon irradiation, the drug is uncaged and the fluorescence switched “on,” allowing for real-time monitoring of the drug release. Paul et al 26 showed this ability in vitro using HeLa cells for up to 30 min.…”

Section: Optical Imagingmentioning

confidence: 95%

Theranostic Nanoparticles for Tracking and Monitoring Disease State

Zavaleta

Chung

2018

SLAS Technology

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The development of novel nanoparticles consisting of both diagnostic and therapeutic components has increased over the past decade. These “theranostic” nanoparticles have been tailored toward one or more types of imaging modalities and have been developed for optical imaging, magnetic resonance imaging, ultrasound, computed tomography, and nuclear imaging comprising both single-photon computed tomography and positron emission tomography. In this review, we focus on state-of-the-art theranostic nanoparticles that are capable of both delivering therapy and self-reporting/tracking disease through imaging. We discuss challenges and the opportunity to rapidly adjust treatment for individualized medicine.

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Photoresponsive real time monitoring silicon quantum dots for regulated delivery of anticancer drugs

Abstract: Photoluminescent silicon quantum dots (SiQDs) decorated using o-nitrobenzyl (ONB) derivative as a phototrigger for real-time monitoring of chlorambucil (Cbl) based on Photoinduced Electron Transfer (PET).

Cited by 50 publications

References 32 publications

Three‐Arm, Biotin‐Tagged Carbazole–Dicyanovinyl–Chlorambucil Conjugate: Simultaneous Tumor Targeting, Sensing, and Photoresponsive Anticancer Drug Delivery

Three‐Arm, Biotin‐Tagged Carbazole–Dicyanovinyl–Chlorambucil Conjugate: Simultaneous Tumor Targeting, Sensing, and Photoresponsive Anticancer Drug Delivery

Release of Warfarin from Human Serum Albumin by Water‐soluble CdSe Nanotetrapods

Theranostic Nanoparticles for Tracking and Monitoring Disease State

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