Photoscanning of Bone Lesions Utilizing Strontium 85

Wh, Fleming; Jd, McILRAITH; Er, King

doi:10.1148/77.4.635

Cited by 90 publications

(15 citation statements)

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“…Prostate cancer was diagnosed in ≈ 23 000 men in England and Wales in 1998, and the latest data from 1991–93 show a 5‐year survival of prostate cancer in the UK of about 50%[1]. The detection of bone metastases using isotope bone scans was first described (using strontium) in the early 1960s and they have long been the reference standard investigation for detecting bone metastases in prostate cancer [2,3]. Bone scans using 99m Tc‐labelled diphosphonates are very sensitive but the specificity can be reduced in older men.…”

Section: Introductionmentioning

confidence: 99%

Broadening the criteria for avoiding staging bone scans in prostate cancer: a retrospective study of patients at the Royal Marsden Hospital

O’Sullivan¹,

Norman²,

Cook

et al. 2003

BJU International

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who had histologically confirmed prostate cancer on biopsy reviewed at the Royal Marsden. Data were analysed according to Gleason score, major Gleason grade, clinical T-stage and PSA level. RESULTSIn all, 420 patients were identified who fulfilled the criteria for inclusion; 67 scans (16%, 95% confidence interval, CI, 13-20%) were positive. Of the 187 scans taken in patients with a PSA level of £ 20 ng/mL, stage

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Section: Introductionmentioning

confidence: 99%

Broadening the criteria for avoiding staging bone scans in prostate cancer: a retrospective study of patients at the Royal Marsden Hospital

O’Sullivan¹,

Norman²,

Cook

et al. 2003

BJU International

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“…In 1961, Flemming et al [4] described a new technique, using 85Sr, for the detection of such lesions -the Photo scan, and in 1971 the substitution o f99mTc for 85Sr by Subramanian et al [5] marked a significant improvement of this technique.…”

Section: Introductionmentioning

confidence: 99%

Comparison of the Sensitivity of <sup>99m</sup>Tc-Methyl Diphosphonate Bone Scan with the Skeletal X-Ray Survey in Multiple Myeloma

R¹,

Glanz²,

Lubin³

et al. 1983

Acta Haematol

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In the diagnosis of multiple myeloma (MM), the radiological skeletal survey (RSS) was proven to be most useful for the detection of bone lesions. Since 1961, a new technique radioisotopic bone scan (RIBS), for the detection of such lesions, using ⁸⁵Sr and ^99mTc, has been shown to be highly sensitive for the detection of skeletal metastases of epithelial tumors. We have studied 30 patients with plasma cell dyscrasia (PCD) by both methods and concluded that RSS is clearly superior to RIBS in PCD. As RIBS detected less than 50% of the lesions demonstrated by RSS there seems to be no indication for a routine RIBS in the initial work-up of patients suspected to have PCD. However, due to the fact that RIBS is useful for the detection of new bone formation it has a certain value in the localization of pathological fractures in MM, mainly in vertebral compression.

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“…Nevertheless, bone was considered metabolically inactive until the demonstration of 32 P uptake in the skeleton of rats in 1935 (Chiewitz & Hevesy 1935). Bone imaging with radionuclides originated with the published work of Fleming, who used 85 Sr to image a human pelvis (Fleming et al 1961). Although its brief half‐life of 2.8 h allowed large doses of tracer, its clearance was slow, and signal‐to‐noise ratios made imaging difficult.…”

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confidence: 99%

Radioimaging of implants in rats using Tc‐99m‐MDP

McCracken¹,

Lemons²,

Zinn³

et al. 2001

Clinical Oral Implants Res

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Radiopharmaceutical isotopes are widely used clinically to detect tumors of osteogenic origin. One example is Technetium-99m methylene diphosphonate (Tc-99m-MDP). When viewed with a gamma camera, the concentration of the isotope (increased gamma activity) indicates an area of increased bone activity. This technology provides an opportunity to measure bone growth around implants in vivo. The purpose of this study was to measure Tc-99m-MDP activity around titanium alloy implants placed in the tibiae of rats. Some implant sites were treated with a growth factor; other sites served as controls. The hypothesis tested was that implants placed with a growth factor would have greater associated Tc-99m-MDP activity. Twelve adult male Sprague-Dawley rats were anesthetized and surgical access to the medial proximal tibiae was obtained. Titanium alloy screw implants were placed in six animals along with 65 microgram of acidic fibroblast growth factor (FGF-1); the other six animals received implants only and served as controls. After five days, rats were injected with 1500 microCi of Tc-99m-MDP. After 3 hours, rats were imaged with a gamma camera. The Tc-99m-MDP intensity associated with each implant was quantified and the means for each group were compared using ANOVA. Implants treated with FGF-1 demonstrated significantly more Tc-99m-MDP activity than implants alone. This suggests that Tc-99m-MDP analysis may be a useful tool for determining bone growth around implants in laboratory animals in vivo.

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Photoscanning of Bone Lesions Utilizing Strontium 85

Cited by 90 publications

References 0 publications

Broadening the criteria for avoiding staging bone scans in prostate cancer: a retrospective study of patients at the Royal Marsden Hospital

Broadening the criteria for avoiding staging bone scans in prostate cancer: a retrospective study of patients at the Royal Marsden Hospital

Comparison of the Sensitivity of <sup>99m</sup>Tc-Methyl Diphosphonate Bone Scan with the Skeletal X-Ray Survey in Multiple Myeloma

Radioimaging of implants in rats using Tc‐99m‐MDP

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