2008
DOI: 10.1517/17425240802444673
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Photosensitiser delivery for photodynamic therapy. Part 2: systemic carrier platforms

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Cited by 99 publications
(62 citation statements)
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“…While this may be true for the prohibitively expensive development of chemically-modified new photosensitizers [33] focusing on the use of new delivery methods, formulations and enhanced targeting approaches offers significant potential. Especially the use of existing photosensitizers in conjunction with nanoparticles and a move to "nanomedicine" presents an intriguing possibility [34]. This approach has shows promising results and can play an important role for enhancing PDT efficacy.…”
Section: Introductionmentioning
confidence: 99%
“…While this may be true for the prohibitively expensive development of chemically-modified new photosensitizers [33] focusing on the use of new delivery methods, formulations and enhanced targeting approaches offers significant potential. Especially the use of existing photosensitizers in conjunction with nanoparticles and a move to "nanomedicine" presents an intriguing possibility [34]. This approach has shows promising results and can play an important role for enhancing PDT efficacy.…”
Section: Introductionmentioning
confidence: 99%
“…Endocytosis inhibitor treatment was required to maintain the serum-free conditions throughout the experiment. Cells were treated with the six inhibitors chlorpromazine, chloroquine, nocodazole, 2-deoxy-d-glucose, colchicine, and NH 4 Cl at the suggested concentrations for 30 min before the addition of PL TPA M. 21,22 In vitro cytotoxicity…”
Section: Tpa Cross-section Determinationmentioning
confidence: 99%
“…The extended delocalized aromatic π electron system of PS molecules leads to aggregation, which subsequently inhibits ROS generation. 4 To improve the solubility of PSs, various polymeric micelles have been used as drug carriers. 5 Meanwhile, micellar drug delivery systems can enhance drug accumulation in tumor tissues by the enhanced permeability and retention (EPR) effect.…”
Section: Introductionmentioning
confidence: 99%
“…It can range from polyethylene glycol (PEG) chains, amide bonds, triazole rings, ether linkages, etc., all discussed below. As an established area on its own, there are many examples of such bioconjugates now available [43] . These include porphyrins with steroids, lipids, peptides, carbohydrates, lectins and nucleotides.…”
Section: Porphyrin Bioconjugatesmentioning
confidence: 99%