Photosensitive drug delivery systems for cancer therapy: Mechanisms and applications

Pan, Patrick; Svirskis, Darren; Rees, Shaun W. P.; Barker, David; Waterhouse, Geoffrey I. N.; Wu, Zimei

doi:10.1016/j.jconrel.2021.08.053

Cited by 67 publications

(36 citation statements)

References 190 publications

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“…Only a few molecules can respond directly to two-photon NIR irradiation, usually requiring high-intensity and long-duration laser excitation to photoactivate molecules or disrupt the polymersomes and subsequently release the cargo. On the contrary, many photoreactions occur under one-photon UV irradiation, as photons at these wavelengths possess the required energy per photon to break covalent bonds [ 279 ] but UV light is phototoxic [ 235 , 237 ]. Strategies based on upconversion (UC) processes have been proposed to overcome the release time limitations associated with NIR and the phototoxic effects of UV irradiation, showing potential in applications related to NIR-light-controlled drug delivery systems.…”

Section: Light-responsive Polymersomes For Anticancer Therapeutic Del...mentioning

confidence: 99%

Light-Triggered Polymersome-Based Anticancer Therapeutics Delivery

et al. 2022

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Polymersomes are biomimetic cell membrane-like model structures that are self-assembled stepwise from amphiphilic copolymers. These polymeric (nano)carriers have gained the scientific community’s attention due to their biocompatibility, versatility, and higher stability than liposomes. Their tunable properties, such as composition, size, shape, and surface functional groups, extend encapsulation possibilities to either hydrophilic or hydrophobic cargoes (or both) and their site-specific delivery. Besides, polymersomes can disassemble in response to different stimuli, including light, for controlling the “on-demand” release of cargo that may also respond to light as photosensitizers and plasmonic nanostructures. Thus, polymersomes can be spatiotemporally stimulated by light of a wide wavelength range, whose exogenous response may activate light-stimulable moieties, enhance the drug efficacy, decrease side effects, and, thus, be broadly employed in photoinduced therapy. This review describes current light-responsive polymersomes evaluated for anticancer therapy. It includes light-activable moieties’ features and polymersomes’ composition and release behavior, focusing on recent advances and applications in cancer therapy, current trends, and photosensitive polymersomes’ perspectives.

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Section: Light-responsive Polymersomes For Anticancer Therapeutic Del...mentioning

confidence: 99%

Light-Triggered Polymersome-Based Anticancer Therapeutics Delivery

et al. 2022

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“…Naturally, the microfluidic approach can also be expanded to other applications where the photochemical performance is dependent on molecular oxygen, such as photodynamic therapy, 25 light-triggered drug release by photooxidation, 26 and some photocatalytic processes 27 and even to their high-throughput experimentation. The ability to accurately and rapidly determine the UC performance under a range of oxygen levels can for example facilitate the design of more selective imaging agents and safer cancer therapies due to the difference in oxygen levels in healthy and cancerous tissue.…”

Section: Resultsmentioning

confidence: 99%

Microfluidic oxygen tolerability screening of nanocarriers for triplet fusion photon upconversion

et al. 2022

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“…Photothermal therapy has received increasing attention as a newer form of cancer therapy. [86][87][88][89] This approach uses light-triggered NPs incorporated within the polymeric hydrogel to generate heat at the tumor site, thereby, killing tumor cells. In cancer immunotherapy, hydrogels have been developed as systems for delivering immunomodulatory molecules such as antigens, cytokines, peptides, and nucleic acids.…”

Section: Progress With Minimally Invasive Tumor Ablation Therapymentioning

confidence: 99%

Contact‐Free Remote Manipulation of Hydrogel Properties Using Light‐Triggerable Nanoparticles: A Materials Science Perspective for Biomedical Applications

Choi

Chakraborty

Coyle

et al. 2022

Adv Healthcare Materials

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Considerable progress has been made in synthesizing "intelligent", biodegradable hydrogels that undergo rapid changes in physicochemical properties once exposed to external stimuli. These advantageous properties of stimulus-triggered materials make them highly appealing to diverse biomedical applications. Of late, research on the incorporation of light-triggered nanoparticles (NPs) into polymeric hydrogel networks has gained momentum due to their ability to remotely tune hydrogel properties using facile, contact-free approaches, such as adjustment of wavelength and intensity of light source. These multi-functional NPs, in combination with tissue-mimicking hydrogels, are increasingly being used for on-demand drug release, preparing diagnostic kits, and fabricating smart scaffolds. Here, the authors discuss the atomic behavior of different NPs in the presence of light, and critically review the mechanisms by which NPs convert light stimuli into heat energy. Then, they explain how these NPs impact the mechanical properties and rheological behavior of NPs-impregnated hydrogels. Understanding the rheological behavior of nanocomposite hydrogels using different sophisticated strategies, including computer-assisted machine learning, is critical for designing the next generation of drug delivery systems. Next, they highlight the salient strategies that have been used to apply light-induced nanocomposites for diverse biomedical applications and provide an outlook for the further improvement of these NPs-driven light-responsive hydrogels.

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Photosensitive drug delivery systems for cancer therapy: Mechanisms and applications

Cited by 67 publications

References 190 publications

Light-Triggered Polymersome-Based Anticancer Therapeutics Delivery

Light-Triggered Polymersome-Based Anticancer Therapeutics Delivery

Microfluidic oxygen tolerability screening of nanocarriers for triplet fusion photon upconversion

Contact‐Free Remote Manipulation of Hydrogel Properties Using Light‐Triggerable Nanoparticles: A Materials Science Perspective for Biomedical Applications

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