Photosensitivity and Photoreactions

Paller, Amy S.; Mancini, Anthony J.

doi:10.1016/b978-1-4377-0412-9.00019-8

Cited by 3 publications

(6 citation statements)

References 179 publications

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“…2 In this patient, the cutaneous lesion first The emergence of epithelial neoplasms, severe ocular involvement, and progressive neurological degeneration are some of the clinical manifestations of XP. 10 One of the most common malignancies following XP is SCC. 7 To date, all of XP cases in our hospital came with some form of skin cancer, whether it is BCC or SCC.…”

Section: Discussionmentioning

confidence: 99%

“…Following continuous exposure to UV light, individuals with XP can show signs of conjunctival melanosis, cataracts, atrophy, entropion or ectropion, trichiasis, and loss of the lower eyelid. 10 Ocular surface squamous neoplasia (OSSN) is a general term used for all premalignant epithelial lesions and malignancies occurring in the conjunctiva and cornea. This is most commonly found in the interpalpebral area near the limbus.…”

Section: Discussionmentioning

confidence: 99%

“…The management of patients with XP consists of lifetime protection from UV exposure as well as the early detection and treatment of neoplasms, oral medication with isotretinoin or vitamin D, hearing aids for some with hearing loss, frequent eye examination by ophthalmologists, pre-cancerous lesion examination by dermatologists, and psychosocial issues solving. 2,10 Psychosocial issues should be taken are such as social isolation from school friends, career prospects, and many more to prevent further impact on patient self-confidence. 2 In this case, the patient no longer goes to school and rarely plays with friends because of her condition.…”

Section: Discussionmentioning

confidence: 99%

“…9 Management of patients with XP involves lifetime protection against exposure to UV radiation, as well as early detection and treatment of neoplasms. 10 Regular visits to a dermatologist should be taken to remove any pre-cancerous lesion as early as possible. 2 Skin neoplasms should be treated by a procedure such as electrodesiccation and curettage, surgical excision, or Mohs surgery.…”

Section: Introductionmentioning

confidence: 99%

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Xeroderma Pigmentosum with Simultaneous Cutaneous and Ocular Squamous Cell Carcinoma

Effendi¹,

Fadhlih²,

Diana³

et al. 2022

CCID

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Xeroderma pigmentosum (XP) is a rare autosomal recessive disease that disrupts deoxyribonucleic acid (DNA) repair due to ultraviolet (UV) radiation. XP is characterized by extreme sensitivity to sunlight, photophobia, cutaneous lesions in the form of freckle-like hyperpigmented macules, and neoplasia on the skin surface. Malignancy is a common complication found in areas exposed to UV light. Squamous cell carcinomas (SCC) is the most common malignancy seen in patients with XP. This report illustrates a case of XP in a six-yearold girl with cutaneous and ocular SCC. The diagnosis of XP was established based on the patient's history and the presence of typical clinical manifestations. Dermoscopy and histopathology examinations confirmed the presence of SCC on the face and eyes. The management of XP patients includes early diagnosis, lifelong UV protection, and early detection of cutaneous malignancy. Early detection and appropriate management are very important in preventing the occurrence of malignancy.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Xeroderma Pigmentosum with Simultaneous Cutaneous and Ocular Squamous Cell Carcinoma

Effendi¹,

Fadhlih²,

Diana³

et al. 2022

CCID

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“…[ 64 65 66 ] Papular thickening of the skin characterized by a leathery or pebbly appearance, most prominently over the knuckles and nose is seen as a chronic cuatneous manifestation in erythropoietic protoporphyria. [ 67 ]…”

Section: Papulonodular Lesionsmentioning

confidence: 99%

Knuckle lesions in inherited and acquired disorders

Adya

Inamadar

Palit

et al. 2021

Indian Dermatology Online Journal

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Skin lesions occurring over the knuckles can be a primary or characteristic manifestation of a disorder. Characteristic knuckle lesions may also be important cutaneous features of various internal disorders when they serve as useful clinical pointers, as well as may speak of the disease severity in certain instances. Furthermore, knuckle lesions also speak of various external factors as the underlying cause of the disease/lesions, such as trauma – occupational or otherwise, and contact dermatitis. Although knuckles essentially imply dorsal aspect of the metacarpophalangeal joints, many of the lesions described as those 'involving the knuckles' are seen over the proximal and/or less frequently, the distal interphalangel joints as well. This review presents a compilation of various inherited and acquired dermatoses and dermatological manifestations of various internal disorders associated with different forms of knuckle lesions.

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