Photosensitivity in Immunocompromised Patients Receiving Long-term Therapy With Oral Voriconazole

Voriconazole-induced Phototoxicity in Children

“…15 Our results demonstrate that phototoxic skin reactions [2][3][4][5][7][8][9][12][13][14] (see Table, Supplemental Digital Content 4, http://links.lww.com/INF/B156). The data generated in the present case series of 7 patients indicate that voriconazole-induced phototoxic skin reactions in children are common.…”

“…1 Adverse skin reactions related to voriconazole treatment include erythema, cheilitis, urticaria, Stevens-Johnson syndrome, discoid lupus erythematodes, erythema multiforme, pseudoporphyria, squamous cell carcinoma, melanoma, phototoxicity and photosensitivity reactions. [2][3][4][5][6][7][8][9][10][11][12][13][14] We describe an unusually high incidence of voriconazoleassociated phototoxicity affecting 7 of 21 immunocompromised children who received voriconazole as antifungal prophylaxis due to major hospital renovation work during intensive chemotherapy phases between February 2007 and April 2008.…”

Voriconazole-Induced Photosensitivity in Children

“…In 7 of the 12 children, antifungal therapy was changed to posaconazole in 6 cases and to itraconazole in 1 case. 7 - 10 Voriconazole was continued in 3 cases: in 2 cases at the current dose and in 1 case at a lower dose. 5 , 12 In a study by Walsh et al of 58 patients who received voriconazole, 8 had skin rash and 3 developed photosensitivity reaction that were long lasting (>30 days) but did not require discontinuation of the drug.…”

Photosensitivity reactions and skin tumours associated with voriconazole

“…15 Three cases of voriconazole-induced photosensitivity occurred in immunocompromised children: a 1-month-old boy, a 3-year-old boy, and a 16-year-old girl. 16 Erythematous lesions, some vesicular, appeared on the face and other sunexposed areas.…”