Photosensitivity induced by fibric acid derivatives and its relation to photocontact dermatitis to ketoprofen

Singlet oxygen production and in vitro phototoxicity studies on fenofibrate, mycophenolate mofetil, trifusal, and their active metabolites

“…Overall, the results obtained in the 2 types of experiments indicate that the benzophenone chromophore present in FFB and FFA is the only significant active moiety as regards 1 O 2 production and phototoxicity within the investigated series of compounds. This is in agreement with the case reports on the appearance of phototoxic reactions experienced after administration of the drugs to a number of patients …”

Fenofibrate photoallergy – relevance of patch and photopatch testing

“…The photosensitizing capacity of fenofibrate is mainly determined by the photoexcited chemical structure, the benzophenone moiety, which has also been shown to be responsible for the photosensitizing properties of some other drugs, such as ketoprofen . This fact explains the high prevalence of cross‐photosensitization between these drugs, as observed in the reported case.…”

Ketoprofen Allergic Reactions

“…Coz concluded that the photoallergy is due to benzophenone moiety in ketoprofen or to a closely related thiophene-phenylketone part of the tiaprofenic acid rather than their arylpropionic acid function. Sugiura study concluded that the benzoyl radical, not benzophenone is the key structure for the photosensitization of KP suprofen and tiaprofenic acid and their photocrossreactivities [18][19][20][21][22][23][24][25][26][27][28][29][30][31][32][33] this contradiction is due to the limitation of the speculation from the clinical data. Patients had different personal histories using several kinds of drugs.…”