Photosensitization of Bacteria by Furocoumarins and Related Compounds

Fowlks, W. L.; Griffith, D. G.; Oginsky, Evelyn L.

doi:10.1038/181571a0

Cited by 112 publications

(18 citation statements)

References 2 publications

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“…Defensive activity of furanocoumarins consists in their toxicity against phytopatogens (e.g. retardation of DNA synthesis) [11][12][13]. Some furanocoumarins have pharmacological activity as Ca-channel blockers [14], anticoagulants [15] cytostatics, antitumoral [16], antiinflammatorial [17] and antifungal [18] drugs.…”

Section: Introductionmentioning

confidence: 99%

Influence of the extraction mode on the yield of some furanocoumarins from Pastinaca sativa fruits

Waksmundzka‐Hajnos

Petruczynik

Dragan

et al. 2004

Journal of Chromatography B

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Section: Introductionmentioning

confidence: 99%

Influence of the extraction mode on the yield of some furanocoumarins from Pastinaca sativa fruits

Waksmundzka‐Hajnos

Petruczynik

Dragan

et al. 2004

Journal of Chromatography B

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“…Ziel der Untersuchungen war, Testmodellezu finden, die eine Messung und Objektivierung der photodynamischen Wirksamkeit von 8-MOP -und seinen Derivaten -bei verschiedenen Bestrahlungsarten ermöglichen. In der Literatur fanden wir 4 Arbeiten mit vergleichbarer Problemstellung, aber anderer Versuchsmethodik [2,3,7,8].…”

Section: Einleitung Und Problemstellungunclassified

Zur Wirkung von 8-Methoxypsoralen (8-MOP) und Blacklight auf Mikroorganismen <i>in vitro</i> und den Ablauf der experimentellen Meerschweinchen-Trichophytie

Oberste-Lehn¹,

Plempel²

1977

Dermatology

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The lack of experimental test models causes problems in comparative evaluations of photodynamic effects of 8-MOP and its possible derivatives after irradiation with blacklight or other irradiation sources. In our experiments in vitro, tests with various microorganisms and the in vivo model of experimental dermatophytosis in guinea pigs by Trichophyton mentagrophytes appeared to be suitable. In vivo, 8-MOP was applicated orally and topically in two formulations.

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“…A primary mode of action of the psoralens is to alkylate DNA (Scott et al, 1976), producing profound mutagenic, carcinogenic, and sometimes lethal effects on bacterial cells (Fowlks et al, 1958;Ashwood-Smith et al, 1986). A second reported activity is as an insect antifeedant (Yajima and Munakata, 1979;Muckenstrum et al, 1981).…”

Section: Introductionmentioning

confidence: 99%

Impact of UV radiation on activity of linear furanocoumarins andBacillus thuringiensis var.Kurstaki againstSpodoptera exigua: Implications for tritrophic interactions

et al. 1991

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Acidic fogs with a pH of 2.0 and duration of 2 hr did not reduce the efficacy ofBacillus thuringiensis var.Kurstaki (Berliner). Therefore, the impact of UV radiation was investigated on the interactions between (1) levels of the antibacterial linear furanocoumarins psoralen, bergapten, and xanthotoxin inApium graveolens (L.) occurring following a 2.0 pH acidic fog episode, (2) the noctuidSpodoptera exigua (Hübner), and (3) a sublethal dosage of the microbial pathogenB. thuringiensis var.Kurstaki. Mean time to pupation in the absence of UV radiation (survival was too low to conduct this analysis for insects exposed to UV) was significantly extended by the addition of either psoralens orB. thuringiensis. Larvae developing on diets containingB. thuringiensis plus psoralens required nearly 40% longer to pupate than controls, but their effects were additive as the interaction was not significant. Although the mean times to adult emergence were significantly different, time spent in the pupal stage did not vary significantly between treatments, indicating that increases in larval developmental time were responsible for the observed decrease in developmental rate. Mean time to mortality, a weighted average time of death, was not significantly affected by any of the treatments. In a 2 × 2 × 2 factorial analysis, all main effects (linear furanocoumarins.B. thuringiensis, UV radiation) reduced survival significantly, as did the three-way interaction. Thus, antagonistic interactions with psoralens that would reduce the effectiveness ofB. thuringiensis in the field were not observed. When pairs of main effects were nested within the two levels (presence and absence) of the third factor, several two-way interactions were found. Interestingly, the activity ofB. thuringiensis and the psoralens, individually or in combination, was enhanced by exposure to UV radiation. Implications of this research are discussed for both natural and agricultural ecosystems.

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Photosensitization of Bacteria by Furocoumarins and Related Compounds

Cited by 112 publications

References 2 publications

Influence of the extraction mode on the yield of some furanocoumarins from Pastinaca sativa fruits

Influence of the extraction mode on the yield of some furanocoumarins from Pastinaca sativa fruits

Zur Wirkung von 8-Methoxypsoralen (8-MOP) und Blacklight auf Mikroorganismen <i>in vitro</i> und den Ablauf der experimentellen Meerschweinchen-Trichophytie

Impact of UV radiation on activity of linear furanocoumarins andBacillus thuringiensis var.Kurstaki againstSpodoptera exigua: Implications for tritrophic interactions

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