Photosensitization of Singlet Oxygen and In Vivo Photodynamic Therapeutic Effects Mediated by PEGylated W<sub>18</sub>O<sub>49</sub> Nanowires

Kalluru, Poliraju; Vankayala, Raviraj; Chiang, Chi‐Shiun; Hwang, Kuo Chu

doi:10.1002/anie.201307358

Cited by 156 publications

(94 citation statements)

References 24 publications

(25 reference statements)

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“…In summary, we have presented the first literature example of “nanomaterials‐mediated photodynamic therapy effect” and demonstrated that upon NIR light irradiation, Au NRs can mediate PDT effects to completely destruct B16F0 melanoma tumors in mice in the absence of additional organic photosensitizers . The ability to absorb NIR light and sensitize formation of singlet oxygen is a very important feature of Au NRs, since NIR light has much deeper tissue penentration depths than visible light and is mandatory for PDT treatment of deep tissue‐buried tumors.…”

Section: Resultsmentioning

confidence: 94%

First Demonstration of Gold Nanorods‐Mediated Photodynamic Therapeutic Destruction of Tumors via Near Infra‐Red Light Activation

Vankayala

Huang

Kalluru

et al. 2013

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Previously, a large volume of papers reports that gold nanorods (Au NRs) are able to effectively kill cancer cells upon high laser doses (usually 808 nm, 1-48 W/cm²) irradiation, leading to hyperthermia-induced destruction of cancer cells, i.e, photothermal therapy (PTT) effects. Combination of Au NRs-mediated PTT and organic photosensitizers-mediated photodynamic therapy (PDT) were also reported to achieve synergistic PTT and PDT effects on killing cancer cells. Herein, we demonstrate for the first time that Au NRs alone can sensitize formation of singlet oxygen (¹O₂) and exert dramatic PDT effects on complete destrcution of tumors in mice under very low LED/laser doses of single photon NIR (915 nm, <130 mW/cm²) light excitation. By changing the NIR light excitation wavelengths, Au NRs-mediated phototherapeutic effects can be switched from PDT to PTT or combination of both. Both PDT and PTT effects were confirmed by measurements of reactive oxygen species (ROS) and heat shock protein (HSP 70), singlet oxygen sensor green (SOSG) sensing, and sodium azide quenching in cellular experiments. In vivo mice experiments further show that the PDT effect via irradiation of Au NRs by 915 nm can destruct the B16F0 melanoma tumor in mice far more effectively than doxorubicin (a clinically used anti-cancer drug) as well as the PTT effect (via irradiation of Au NRs by 780 nm light). In addition, we show that Au NRs can emit single photon-induced fluorescence to illustrate their in vivo locations/distribution.

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Section: Resultsmentioning

confidence: 94%

First Demonstration of Gold Nanorods‐Mediated Photodynamic Therapeutic Destruction of Tumors via Near Infra‐Red Light Activation

Vankayala

Huang

Kalluru

et al. 2013

Small

Self Cite

218

192

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“…As a result, the method has been widely used to detect 1 O 2 photosensitized by various materials including semiconductors and metals. [ 34,39,40 ] For instance, such phosphorescence has been observed on Ag, Au and Pt, which indicates that these metals can photosensitize the formation of 1 O 2 . [ 34 ] However − .…”

Section: Progress Reportmentioning

confidence: 95%

Palladium‐Based Nanomaterials: A Platform to Produce Reactive Oxygen Species for Catalyzing Oxidation Reactions

et al. 2015

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Oxidation reactions by molecular oxygen (O2 ) over palladium (Pd)-based nanomaterials are a series of processes crucial to the synthesis of fine chemicals. In the past decades, investigations of related catalytic materials have mainly been focused on the synthesis of Pd-based nanomaterials from the angle of tailoring their surface structures, compositions and supporting materials, in efforts to improve their activities in organic reactions. From the perspective of rational materials design, it is imperative to address the fundamental issues associated with catalyst performance, one of which should be oxygen activation by Pd-based nanomaterials. Here, the fundamentals that account for the transformation from O2 to reactive oxygen species over Pd, with a focus on singlet O2 and its analogue, are introduced. Methods for detecting and differentiating species are also presented to facilitate future fundamental research. Key factors for tuning the oxygen activation efficiencies of catalytic materials are then outlined, and recent developments in Pd-catalyzed oxygen-related organic reactions are summarized in alignment with each key factor. To close, we discuss the challenges and opportunities for photocatalysis research at this unique intersection as well as the potential impact on other research fields.

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“…41 This type of light-triggered treatment modality has remarkably improved selectivity and fewer side effects as compared to conventional radiotherapies and chemotherapies. 43,44 Recent studies mainly focused on the photosensitizer-photothermal agent composite nanostructures for simultaneous PDT/PTT therapy triggered by a single NIR laser. 43,44 Recent studies mainly focused on the photosensitizer-photothermal agent composite nanostructures for simultaneous PDT/PTT therapy triggered by a single NIR laser.…”

Section: Cytotoxicity Studies In Vitromentioning

confidence: 99%

Near-infrared-triggered in situ hybrid hydrogel system for synergistic cancer therapy

Zhang

Zhu

et al. 2015

J. Mater. Chem. B

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Photosensitization of Singlet Oxygen and In Vivo Photodynamic Therapeutic Effects Mediated by PEGylated W₁₈O₄₉ Nanowires

Cited by 156 publications

References 24 publications

First Demonstration of Gold Nanorods‐Mediated Photodynamic Therapeutic Destruction of Tumors via Near Infra‐Red Light Activation

First Demonstration of Gold Nanorods‐Mediated Photodynamic Therapeutic Destruction of Tumors via Near Infra‐Red Light Activation

Palladium‐Based Nanomaterials: A Platform to Produce Reactive Oxygen Species for Catalyzing Oxidation Reactions

Near-infrared-triggered in situ hybrid hydrogel system for synergistic cancer therapy

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Photosensitization of Singlet Oxygen and In Vivo Photodynamic Therapeutic Effects Mediated by PEGylated W18O49 Nanowires

Cited by 156 publications

References 24 publications

First Demonstration of Gold Nanorods‐Mediated Photodynamic Therapeutic Destruction of Tumors via Near Infra‐Red Light Activation

First Demonstration of Gold Nanorods‐Mediated Photodynamic Therapeutic Destruction of Tumors via Near Infra‐Red Light Activation

Palladium‐Based Nanomaterials: A Platform to Produce Reactive Oxygen Species for Catalyzing Oxidation Reactions

Near-infrared-triggered in situ hybrid hydrogel system for synergistic cancer therapy

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Product

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Photosensitization of Singlet Oxygen and In Vivo Photodynamic Therapeutic Effects Mediated by PEGylated W₁₈O₄₉ Nanowires