Photosensitization With Bacteriochlorins

Abstract

Biophysical and photobiological properties of a group of bacteriochlorins were compared with efficacy of these products for photodynamic therapy of murine tumors. Predictive factors for selective photosensitization in vivo include affinity binding to lipoproteins greater than albumin, extinction coefficient at the wavelength of irradiation and tumor/skin distribution. Efficacy was correlated with circulating plasma levels of the different sensitizers but not with the photodynamic therapy response in cell culture.

Synthesis of amphiphilic sulfonamide halogenated porphyrins: MALDI-TOFMS characterization and evaluation of 1-octanol/water partition coefficients

“…[38][39][40] The desired sulfonamide porphyrin was dissolved in 1-octanol saturated with phosphate buffer (PBS). This solution was then added to a PBS solution saturated with 1-octanol.…”

“…[38][39][40] The sulfonamide halogenated porphyrin (8Â10 À2 mmol) is dissolved in 5 mL of 1-octanol previously saturated with a solution of PBS pH¼7.4. The same volume (5 mL) of a PBS solution, saturated with 1-octanol, was added to the 1-octanol phase, mixed vigorously for 3 min and then the phases were separated by centrifugation (4000 rpm, 2 min).…”

Synthesis and characterization of biocompatible bimodal meso-sulfonamide-perfluorophenylporphyrins

“…We also evaluated the effect of the number of sulfonamide substituents on the 1-octanol/water partition coefficients using a minor modification of the shake-flask method [46][47][48]. The desired sulfonamide porphyrin was dissolved in 1-octanol saturated with phosphate buffer (PBS).…”

Spectral and photosensitizing properties of bacteriochlorin a and its monomethyl and dimethyl esters

“…Accordingly, BChl a and its derivatives are more promising for photodynamic therapy purposes because of their spectral characteristics. A series of BChl a derivatives (bacteriopheophorbid a [3,4], bacteriochlorin a (BCA) [5,6], bacteriopurpurin a [7,8], and also their conjugates with amino acids [1, 9,10]) exhibit high photodynamic activity in vivo and in vitro. In this case, we observe photodynamic effects with formation of both singlet molecular oxygen and radical products [5,6,11].…”