Photosensitizer-singlet oxygen sensor conjugated silica nanoparticles for photodynamic therapy and bioimaging

Sobhanan, Jeladhara; Ono, Kenji; Okamoto, Takuya; Sawada, Makoto; Weiss, Paul S.; Biju, Vasudevanpillai

doi:10.1039/d3sc03877g

Chem. Sci.

2024

DOI: 10.1039/d3sc03877g

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Photosensitizer-singlet oxygen sensor conjugated silica nanoparticles for photodynamic therapy and bioimaging

Jeladhara Sobhanan,

Kenji Ono,

Takuya Okamoto

et al.

Abstract: Intracellular singlet oxygen (1O2) generation and detection help optimize the outcome of photodynamic therapy (PDT). Theranostics programmed for on-demand phototriggered 1O2 release and bioimaging have great potential to transform PDT....

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Cited by 4 publications

References 70 publications

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Anthracene‐Based Endoperoxides as Self‐Sensitized Singlet Oxygen Carriers for Hypoxic‐Tumor Photodynamic Therapy

He,

Tang

2024

Adv Healthcare Materials

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Singlet oxygen is a crucial reactive oxygen species (ROS) in photodynamic therapy (PDT). However, the hypoxic tumor microenvironment limits the production of cytotoxic singlet oxygen through the light irradiation of PDT photosensitizers (PSs). This restriction poses a major challenge in improving the effectiveness of PDT. To overcome this challenge, researchers have explored the development of singlet oxygen carriers that can capture and release singlet oxygen in physiological conditions. Among these developments, anthracene‐based endoperoxides, initially discovered almost 100 years ago, have shown the ability to generate singlet oxygen controllably under thermal or photo stimuli. Recent advancements have led to the development of a new class of self‐sensitized anthracene‐endoperoxides, with potential applications in enhancing PDT effects for hypoxic tumors. This review discusses the current research progress in utilizing self‐sensitized anthracene‐endoperoxides as singlet oxygen carriers for improved PDT. It covers anthracene‐conjugated small organic molecules, metal–organic complexes, polymeric structures, and other self‐sensitized nano‐structures. The molecular structural designs, mechanisms, and characteristics of these systems will be discussed. This review aims to provide valuable insights for developing high‐performance singlet oxygen carriers for hypoxic‐tumor PDT.

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Anthracene‐Based Endoperoxides as Self‐Sensitized Singlet Oxygen Carriers for Hypoxic‐Tumor Photodynamic Therapy

He,

Tang

2024

Adv Healthcare Materials

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Influence of supramolecular self-assembly of oppositely charged Co- and Sn-porphyrins on the their spectral-luminescent properties in aqueous and aqueous micellar media of ionic surfactants

Kaigorodova,

Mamardashvili,

Kurochkin

et al. 2024

Optical Materials

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Design of “green” plasmonic nanocomposites with multi-band blue emission for ultrafast laser hyperthermia

Ryabchikov

2024

Nanoscale

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Photosensitizer-singlet oxygen sensor conjugated silica nanoparticles for photodynamic therapy and bioimaging

Abstract: Intracellular singlet oxygen (1O2) generation and detection help optimize the outcome of photodynamic therapy (PDT). Theranostics programmed for on-demand phototriggered 1O2 release and bioimaging have great potential to transform PDT....

Cited by 4 publications

References 70 publications

Anthracene‐Based Endoperoxides as Self‐Sensitized Singlet Oxygen Carriers for Hypoxic‐Tumor Photodynamic Therapy

Anthracene‐Based Endoperoxides as Self‐Sensitized Singlet Oxygen Carriers for Hypoxic‐Tumor Photodynamic Therapy

Influence of supramolecular self-assembly of oppositely charged Co- and Sn-porphyrins on the their spectral-luminescent properties in aqueous and aqueous micellar media of ionic surfactants

Design of “green” plasmonic nanocomposites with multi-band blue emission for ultrafast laser hyperthermia

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