Photosensitizers attenuate LPS-induced inflammation: implications in dentistry and general health

Couto, Ana Carolina Fernandes; Carvalho, Roberto Gameiro de; Brancini, Guilherme Thomaz Pereira; Martins, Fernando Grine; Sorgi, Carlos Artério; Silva, Léa Assed Bezerra da; Filho, Paulo Nelson; Paula-Silva, Francisco Wanderley Garcia; Borsatto, Maria Cristina; Braga, Gilberto Úbida Leite; Júnior, Arthur Belém Novaes

doi:10.1007/s10103-020-03180-2

Cited by 8 publications

(4 citation statements)

References 108 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Recent reports have explored the role of aPDT in the inflammatory cytokines in the periodontitis microenvironment. A recent investigation pointed out that some PSs could interact with LPS, modify the structure of LPS, and alter the biological effects in cells, which may provide a different insight into the treatments not only in dentistry but also in general health (Couto et al, 2021). The result was in line with the findings of Matsushima et al (2021) who observed that aPDT treatment could lead to LPS decrease, organic resolution, organic debris removal, and root surface cleaning.…”

Section: Biofilm Growth/ Substratesupporting

confidence: 67%

Antimicrobial photodynamic therapy against oral biofilm: influencing factors, mechanisms, and combined actions with other strategies

Li¹,

Sun

Xie³

et al. 2023

Front. Microbiol.

View full text Add to dashboard Cite

Oral biofilms are a prominent cause of a wide variety of oral infectious diseases which are still considered as growing public health problems worldwide. Oral biofilms harbor specific virulence factors that would aggravate the infectious process and present resistance to some traditional therapies. Antimicrobial photodynamic therapy (aPDT) has been proposed as a potential approach to eliminate oral biofilms via in situ-generated reactive oxygen species. Although numerous types of research have investigated the effectiveness of aPDT, few review articles have listed the antimicrobial mechanisms of aPDT on oral biofilms and new methods to improve the efficiency of aPDT. The review aims to summarize the virulence factors of oral biofilms, the progress of aPDT in various oral biofilm elimination, the mechanism mediated by aPDT, and combinatorial approaches of aPDT with other traditional agents.

show abstract

Section: Biofilm Growth/ Substratesupporting

confidence: 67%

Antimicrobial photodynamic therapy against oral biofilm: influencing factors, mechanisms, and combined actions with other strategies

Li¹,

Sun

Xie³

et al. 2023

Front. Microbiol.

View full text Add to dashboard Cite

show abstract

“…It can be used more frequently than antimicrobials because a-PDT does not cause bacterial resistance [ 15 ]. Moreover a-PDT can inactivate endotoxins that are produced by Gram-negative bacteria [ 59 , 60 ] and can affect wound healing [ 61 ].…”

Section: Discussionmentioning

confidence: 99%

Effectiveness of Photodynamic Therapy as Antiseptic Measure for Oral Cavity and Pharynx: A Systematic Review

Sologova,

Petukhova,

Podoplelova

et al. 2023

Dentistry Journal

View full text Add to dashboard Cite

Background: The complex traditional treatment of inflammation diseases in oral cavity includes the prescription of antibiotic and antiseptic therapy. This systematic review aims to evaluate the effect of photodynamic therapy as a part of management of inflammatory diseases in oral cavity; Methods: The study is presented in accordance with the preferred reporting points for systematic reviews and meta-analyses (PRISMA). This systematic review was conducted using electronic databases such as Medline PubMed, Scopus and the Cochrane Central Register of Controlled Trials. All the studies in this systematic review, were randomized, the risk of bias 2 (ROB 2) were assessed; Results: Considering the inclusion and exclusion criteria, we included 10 randomized clinical trials, published up to 2023 investigating the application of photodynamic therapy as a part of management of inflammatory diseases in oral cavity. The diode laser was used in the oral cavity in the zone of inflammatory process (gingivitis, mucositis, periimplantitis, marginal periodontitis, abscess, periostitis, osteomyelitis etc.) in nine studies or in the zone before surgical procedures in one study; Conclusion: Based on the results of clinical studies, it can be stated that photodynamic therapy shows good results for operations performed in the oral cavity and pharynx.

show abstract

“…Various reviews show that PDT has antibacterial effects on many periodontal pathogens in vitro, 103 and PDT also reduces the biological activity of LPS production by pathogenic bacteria. 104 However, only a little focus is on the plaque microbial changes after PDT treatment. The most common way to detect bacteria is polymerase chain reaction (PCR); sometimes, RNA probes are also used.…”

Section: Bacterial Composition In the Dental Plaque After Pdt-assiste...mentioning

confidence: 99%

Photodynamic therapy in periodontitis: A narrative review

Nie,

Zhang,

Pathak

et al. 2024

Photoderm Photoimm Photomed

View full text Add to dashboard Cite

BackgroundPeriodontitis, a chronic infectious disease, is primarily caused by a dysbiotic microbiome, leading to the destruction of tooth‐supporting tissues and tooth loss. Photodynamic therapy (PDT), which combines excitation light with photosensitizers (PS) and oxygen to produce antibacterial reactive oxygen species, is emerging as a promising adjuvant treatment for periodontitis.MethodsThis review focuses on studies examining the antibacterial effects of PDT against periodontal pathogens. It also explores the impact of PDT on various aspects of periodontal health, including periodontal immune cells, human gingival fibroblasts, gingival collagen, inflammatory mediators, cytokines in the periodontium, vascular oxidative stress, vascular behavior, and alveolar bone health. Clinical trials assessing the types of PSs and light sources used in PDT, as well as its effects on clinical and immune factors in gingival sulcus fluid and the bacterial composition of dental plaque, are discussed.ResultsThe findings indicate that PDT is effective in reducing periodontal pathogens and improving markers of periodontal health. It has shown positive impacts on periodontal immune response, tissue integrity, and alveolar bone preservation. Clinical trials have demonstrated improvements in periodontal health and alterations in the microbial composition of dental plaque when PDT is used alongside conventional treatments.ConclusionsPDT offers a promising adjunctive treatment for periodontitis, with benefits in bacterial reduction, tissue healing, and immune modulation. This article highlights the potential of PDT in periodontal therapy and emphasizes the need for further research to refine its clinical application and efficacy.

show abstract

Photosensitizers attenuate LPS-induced inflammation: implications in dentistry and general health

Cited by 8 publications

References 108 publications

Antimicrobial photodynamic therapy against oral biofilm: influencing factors, mechanisms, and combined actions with other strategies

Antimicrobial photodynamic therapy against oral biofilm: influencing factors, mechanisms, and combined actions with other strategies

Effectiveness of Photodynamic Therapy as Antiseptic Measure for Oral Cavity and Pharynx: A Systematic Review

Photodynamic therapy in periodontitis: A narrative review

Contact Info

Product

Resources

About