Photosensitizers for antibacterial photodynamic therapy based on tetracationic derivatives of synthetic bacteriochlorins

Меерович, Г. А.; Akhlyustina, E. V.; Тиганова, И. Г.; Макарова, Е. А.; Алексеева, Н. В.; Romanishkin, I.D.; Philipova, N. I.; Luk’yanets, E. A.; Гончуков, С. А.; Romanova, Yu. M.; Loschenov, Victor B.

doi:10.1088/1612-202x/aae03f

Cited by 4 publications

(3 citation statements)

References 34 publications

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“…3 and can be classified as neutral, cationic or anionic compounds. Other PSs include phthalocyanines [83], bacteriochlorins [84], BODIPYs [85], and phenothiazines (toluidine blue, aside from MB) [86].…”

Section: Photosensitizer Drugs For Anti-microbial Pdtmentioning

confidence: 99%

Photodynamic Therapy Applications in Cancer, Infections and Cardiovascular Disease

F Isaac-Lam,

Nguyen

2023

TTU J Biomed Sci

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Photodynamic therapy (PDT) or light treatment is a procedure to treat certain types of diseases that uses a photosensitizer (PS) which upon light activation produces cytotoxic oxygen species destroying tumor cells. PDT is minimally-invasive and can be repeated a few times without accumulating significant toxicity in the surrounding tissues. While PDT application in cancer treatment is well established and widely recognized by the scientific community, and its use in the fight against microbial infection is gaining momentum with the rapid increase in antimicrobial multi-drug resistance, its use in the treatment of cardiovascular diseases is clearly marginal. This mini-review presents a brief historical background of PDT, photo-activatable agents utilized, mechanism of photodynamic action, studies in vitro and in vivo, clinical trials, limitations and future prospects of its application in various types of cancer, infections caused by pathogens such as COVID-19, and heart diseases.

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Section: Photosensitizer Drugs For Anti-microbial Pdtmentioning

confidence: 99%

Photodynamic Therapy Applications in Cancer, Infections and Cardiovascular Disease

F Isaac-Lam,

Nguyen

2023

TTU J Biomed Sci

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“…Cationic PS (porphyrins and their analogues), such as chlorins, bacteriochlorins, corollas, phthalocyanines, as well as dyes of various nature (in particular, methylene blue (MB)) are investigated for their application in aPDT [7][8][9][10][11].…”

Section: Introductionmentioning

confidence: 99%

Effect of amphiphilic polymers and sodium alginate on the activity of methylene blue in photogeneration of singlet oxygen ¹О₂

Kuryanova¹,

Kardumyan²,

Kaplin³

et al. 2023

Laser Phys.

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The influence of amphiphilic polymers (APs): poly-N-vinylpyrrolidone, polyethylene glycol and pluronics F127, F108, as well as sodium alginate (SA) on the activity of methylene blue (MB) in the photogeneration of singlet oxygen 1О2, specifically, in a model photooxidation reaction of tryptophan in water was studied. It was shown that in the presence of all the above-mentioned AP, an increase in the effective rate constant (k eff) of tryptophan photooxidation is observed. It was suggested that the observed effect is associated with the interaction of MB with APs, which leads to disaggregation of dye associates. Such disaggregation leads to an increase in the optical density and intensity of MB luminescence. It was also shown that the photocatalytic activity of MB decreases by a factor of 1.5–3.5 in the presence of SA, which is due to the ionic interaction of the cationic MB with polyanionic SA. The interaction of MB with polysaccharide is confirmed by changes in the absorption and fluorescence spectra of the dye. The introduction of APs into a solution containing MB and SA prevents the interaction between MB and polysaccharide, which leads to an increase in the k eff values of tryptophan photooxidation in the presence of MB-AP-SA system, as well as to an increase in the optical density and fluorescence intensity of MB when AP and SA are added. The existence of weak interactions between the hydrophobic groups of MB molecules and the AP (polyvinylpyrrolidone) is also evidenced by the data obtained through 1H-NMR spectroscopy and the degree of MB fluorescence anisotropy. The AFM method shows the change in the surface structure of a thin film obtained by evaporating an aqueous solution of MB-F108-SA compared to the corresponding structure of a film obtained by evaporating an aqueous solution of MB-SA. MB-AP and MB-AP-SA systems may be promising for practical application in the aPDT treatment of chronic microbial superficial infections.

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“…PDI effectiveness of bacteria depends on PS molecular properties-their molecule size and mass, number of cationic groups and their configuration, and photodynamic properties, in particular, quantum yield of singlet oxygen [10]. PDI effectiveness also depends on the process of photodegradation of PS due to the photobleaching phenomenon during irradiation.…”

Section: Introductionmentioning

confidence: 99%

Photodynamic inactivation of Pseudomonas aeruginosa bacterial biofilms using new polycationic photosensitizers

et al. 2019

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The treatment of infected, long-term, non-healing, complicated wounds of the skin and mucosa, trophic ulcers, pressure sores and ulcers of diabetic feet represents a serious problem, especially in the case of resistant and multi-resistant pathogens. Antibacterial photodynamic therapy can be a promising method of local infected foci treatment of such diseases.This work is devoted to the study of the possibility of photodynamic inactivation (PDI) of Pseudomonas aeruginosa bacteria in the form of biofilms with the help of new polycationic photosensitizers (PSs) based on octacationic phthalocyanine and tetra-and octabacteriochlorins (ZnPcChol 8 , (3-PyBrE) 4 BCBr 4 and (3-PyEPy) 4 BCBr 8 ). More specifically, this work aims to clarify the role of light irradiation in PDI with the participation of new PSs, which has not been fully studied, especially with respect to the comparison of different PS types.

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Photosensitizers for antibacterial photodynamic therapy based on tetracationic derivatives of synthetic bacteriochlorins

Cited by 4 publications

References 34 publications

Photodynamic Therapy Applications in Cancer, Infections and Cardiovascular Disease

Photodynamic Therapy Applications in Cancer, Infections and Cardiovascular Disease

Effect of amphiphilic polymers and sodium alginate on the activity of methylene blue in photogeneration of singlet oxygen ¹О₂

Photodynamic inactivation of Pseudomonas aeruginosa bacterial biofilms using new polycationic photosensitizers

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Photosensitizers for antibacterial photodynamic therapy based on tetracationic derivatives of synthetic bacteriochlorins

Cited by 4 publications

References 34 publications

Photodynamic Therapy Applications in Cancer, Infections and Cardiovascular Disease

Photodynamic Therapy Applications in Cancer, Infections and Cardiovascular Disease

Effect of amphiphilic polymers and sodium alginate on the activity of methylene blue in photogeneration of singlet oxygen 1О2

Photodynamic inactivation of Pseudomonas aeruginosa bacterial biofilms using new polycationic photosensitizers

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Effect of amphiphilic polymers and sodium alginate on the activity of methylene blue in photogeneration of singlet oxygen ¹О₂