Photosensitizers with Aggregation-induced Emission and Their Biomedical Applications

Chen, Luojia; Wang, Xingran; Yuan, Yuncong; Hu, Rui; Chen, Qingrong; Zhu, Lijun; Gu, Meijia; Shen, Chao

doi:10.1016/j.engreg.2022.01.005

Cited by 20 publications

(7 citation statements)

References 119 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Light is a frequently used exogenous stimulus in the clinical application of various diseases [102][103][104][105]. Due to the advantages of spatiotemporal selectivity, remote controllability, noninvasiveness, and convenient operation, lightresponsive DDSs based on phototherapies including photoactivated chemotherapy [106,107], photodynamic therapy (PDT) [108][109][110][111], photothermal therapy (PTT) [112][113][114], etc., have been broadly used for cancer treatment [115,116].…”

Section: Lightmentioning

confidence: 99%

Stimuli-Responsive Gene Delivery Nanocarriers for Cancer Therapy

Zhang

Kuang

et al. 2023

Nano-Micro Lett.

View full text Add to dashboard Cite

Gene therapy provides a promising approach in treating cancers with high efficacy and selectivity and few adverse effects. Currently, the development of functional vectors with safety and effectiveness is the intense focus for improving the delivery of nucleic acid drugs for gene therapy. For this purpose, stimuli-responsive nanocarriers displayed strong potential in improving the overall efficiencies of gene therapy and reducing adverse effects via effective protection, prolonged blood circulation, specific tumor accumulation, and controlled release profile of nucleic acid drugs. Besides, synergistic therapy could be achieved when combined with other therapeutic regimens. This review summarizes recent advances in various stimuli-responsive nanocarriers for gene delivery. Particularly, the nanocarriers responding to endogenous stimuli including pH, reactive oxygen species, glutathione, and enzyme, etc., and exogenous stimuli including light, thermo, ultrasound, magnetic field, etc., are introduced. Finally, the future challenges and prospects of stimuli-responsive gene delivery nanocarriers toward potential clinical translation are well discussed. The major objective of this review is to present the biomedical potential of stimuli-responsive gene delivery nanocarriers for cancer therapy and provide guidance for developing novel nanoplatforms that are clinically applicable.

show abstract

Section: Lightmentioning

confidence: 99%

Stimuli-Responsive Gene Delivery Nanocarriers for Cancer Therapy

Zhang

Kuang

et al. 2023

Nano-Micro Lett.

View full text Add to dashboard Cite

show abstract

“…Due to their robust luminosity, large Stokes shift, and strong photobleaching resistance, AIEgens have successful applications in the specific analysis of biomolecules ranging from ions to peptides, carbohydrates, DNA/RNA, enzymes/proteins, and animal modes, among others. 29 The combination of near-infrared (NIR) emission and AIE features has also substantially improved the spectrum properties of organic luminogens, broadening the range of biological applications.…”

Section: Renjun Peimentioning

confidence: 99%

Effective design of organic luminogens for near-infrared-II fluorescence imaging and photo-mediated therapy

Kamya

Cao

et al. 2022

J. Mater. Chem. B

View full text Add to dashboard Cite

show abstract

“…Yet, they may bind to Gram-negative bacteria by electrostatic action and destroy them. AIE-photosensitizers could also bind with the cell wall of drug-resistant fungi and their spores ( Chen et al, 2022 ).…”

Section: Aggregation-induced Emission-photosensitizers In Antimicrobi...mentioning

confidence: 99%

Structure and functions of Aggregation-Induced Emission-Photosensitizers in anticancer and antimicrobial theranostics

2022

View full text Add to dashboard Cite

Photosensitizers with Aggregation-Induced Emission (AIE) can allow the efficient light-mediated generation of Reactive Oxygen Species (ROS) based on their complex molecular structure, while interacting with living cells. They achieve better tissue targeting and allow penetration of different wavelengths of Ultraviolet-Visible-Infrared irradiation. Not surprisingly, they are useful for fluorescence image-guided Photodynamic Therapy (PDT) against cancers of diverse origin. AIE-photosensitizers can also function as broad spectrum antimicrobials, capable of destroying the outer wall of microbes such as bacteria or fungi without the issues of drug resistance, and can also bind to viruses and deactivate them. Often, they exhibit poor solubility and cellular toxicity, which compromise their theranostic efficacy. This could be circumvented by using suitable nanomaterials for improved biological compatibility and cellular targeting. Such dual-function AIE-photosensitizers nanoparticles show unparalleled precision for image-guided detection of tumors as well as generation of ROS for targeted PDT in living systems, even while using low power visible light. In short, the development of AIE-photosensitizer nanoparticles could be a better solution for light-mediated destruction of unwanted eukaryotic cells and selective elimination of prokaryotic pathogens, although, there is a dearth of pre-clinical and clinical data in the literature.

show abstract

Photosensitizers with Aggregation-induced Emission and Their Biomedical Applications

Cited by 20 publications

References 119 publications

Stimuli-Responsive Gene Delivery Nanocarriers for Cancer Therapy

Stimuli-Responsive Gene Delivery Nanocarriers for Cancer Therapy

Effective design of organic luminogens for near-infrared-II fluorescence imaging and photo-mediated therapy

Structure and functions of Aggregation-Induced Emission-Photosensitizers in anticancer and antimicrobial theranostics

Contact Info

Product

Resources

About