Photosensitizing properties of hollow microcapsules built by multilayer self-assembly of poly(allylamine hydrochloride) modified with rose Bengal

Serrano, Mariana Paula; Rafti, Matías; Thomas, Andrés H.; Borsarelli, Claudio D.

doi:10.1039/c9ra03153g

Cited by 9 publications

(4 citation statements)

References 47 publications

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“…Similar characteristic peaks of SA and Gel were also observed in previous studies. − All of the characteristic peaks of SA and gelatin were detected in the IR spectrum of the A 1 :G 0.5 composite hydrogel particles (purple spectrum), indicating the presence of these polymers. In the IR spectrum of pure PAH (blue spectrum), absorption peaks at 3400 cm –1 (combination of N–H stretch and O–H stretch), 2914 and 2860 cm –1 (asymmetric and symmetric C–H stretch), 1602 and 1508 cm –1 (asymmetric and symmetric N–H bending), and 999 cm –1 (C-halogen, Cl stretching) were observed. , Almost all of the spectral peaks of PAH appeared in the IR spectrum of the PAH-coated CA hydrogel particles (pink spectrum), confirming the deposition of PAH on the surface of the CA hydrogel particles.…”

Section: Resultssupporting

confidence: 89%

“…In the IR spectrum of pure PAH (blue spectrum), absorption peaks at 3400 cm −1 (combination of N−H stretch and O−H stretch), 2914 and 2860 cm −1 (asymmetric and symmetric C−H stretch), 1602 and 1508 cm −1 (asymmetric and symmetric N−H bending), and 999 cm −1 (C-halogen, Cl stretching) were observed. 65,66 Almost all of the spectral peaks of PAH appeared in the IR spectrum of the PAH-coated CA hydrogel particles (pink spectrum), confirming the deposition of PAH on the surface of the CA hydrogel particles. Proliferation Ability and Viability of Y1 and HT-22 Cells on Hydrogel Surfaces.…”

Section: Influence Of Concentrations Of Sa and Crosslinking Agent Cac...mentioning

confidence: 99%

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Fabrication and Morphological Control of Nonspherical Alginate Hydrogel Particles

Daradmare,

Son,

Lee

2023

Langmuir

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Section: Resultssupporting

confidence: 89%

Section: Influence Of Concentrations Of Sa and Crosslinking Agent Cac...mentioning

confidence: 99%

Fabrication and Morphological Control of Nonspherical Alginate Hydrogel Particles

Daradmare,

Son,

Lee

2023

Langmuir

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“…23 In one example, RB conjugated to the PAH coat by J Chin Med Assoc covalent linkage, the peak of redshift is at 558 nm with a peak-toshoulder ratio of 1.5, and the triplet lifetime is shortened and 1 O 2 production decreases. 24 Our data indicate that free RB in PAH solution is sufficient to enhance 1 O 2 production but with a slight decrease in high dose of RB upon excitation, and NP-bound RB (N0.5) has a lower capacity for 1 O 2 production (Fig. 6D).…”

Section: Discussionmentioning

confidence: 56%

Effects of polyallylamine-coated nanoparticles on the optical and photochemical properties of rose bengal

Lin

Tsay

Chang

2022

Journal of the Chinese Medical Association

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Background: Inasmuch as optical and photochemical properties of a photosensitizer can be modified upon association with the nanoparticle (NP), we wondered whether the effectiveness of phototherapeutic rose bengal (RB) was affected upon tethering to the sodium lanthanide fluoride NP with an outer polyallylamine (PAH) coat. Methods: RB molecules were electrostatically bound to the NaYF4:Gd3+:Nd3+NPs with inner silica and outer PAH coats. The products were analyzed for their size, shape and zeta potential using transmission electron microscopy and dynamic light scattering instrument. Ultraviolet–visible absorption spectrometry and fluorescence spectrometry were used to examine the spectral properties. Photodynamic effect in terms of singlet oxygen generation was quantitatively determined using the indicator 1,3-diphenylisobenzofuran (DPBF). Photocytotoxicity mediated by NP-bound RB was tested using A549 cells (Student’s t test was used for statistical evaluation). Results: NP-bound RB had the major absorbance peak at 561 nm, in comparison with 549 nm for free RB, accompanied with a significant decrease in absorptivity. The molar extinction coefficient becomes 36 000 M–1 cm–1, only ~35% of that for free RB. Fluorescence spectral analyses showed a paradoxical decrease in the emission with higher NP concentrations even at very low dilutions. Most importantly, the association of RB with these NPs drastically increased its singlet oxygen production upon irradiation. The interaction of RB with PAH coat could partly account for this enhancement, given our finding that PAH in solution also caused a drastic rise in DPBF reactivity by free RB. These NPs exhibited strong photocytotoxic effects, and their promise in photodynamic therapy was addressed. Conclusion: Our findings provide evidence that the PAH coat plays a key role in enhanced biological activities of RB delivered via NPs, including the increase in singlet oxygen production and photocytotoxic effects.

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“…As illustrated in Figures S4 and c, the absorbance of DPBF decreased drastically with time in the presence of UiO-66/DA/vis@pH=7-RB upon illumination, whereas negligible changes were observed in a control experiment involving DPBF with UiO-66/DA/vis@pH=7 or the UiO-66/DA/vis@pH=7-RB without the irradiation, indicating the effective and well-retained ROS generating ability of the UiO-66/DA/vis@pH=7-RB. Therefore, RB integrated into UiO-66/DA/vis@pH=7 allowed to produce ROS “on demand” upon vis irradiation to render the film strongly antibacterial. − …”

Section: Results and Discussionmentioning

confidence: 99%

Formation and Antibacterial Performance of Metal–Organic Framework Films via Dopamine-Mediated Fast Assembly under Visible Light

Hao

Jiang

et al. 2020

ACS Sustainable Chem. Eng.

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Metal–organic frameworks (MOFs) have recently attracted intensive interest toward a variety of potential applications due to their very high porosity. However, the preparation of MOF films is tedious and involves complicated procedures. Herein, we report a simple and widely applicable strategy to fabricate uniform MOF layers on desired substrates via dopamine (DA) codeposition from neutral (pH = 7) aqueous MOF particle dispersions mediated by visible light (vis). Uniquely, DA and MOF at pH 7 under vis illumination created a synergistic condition, leading to the formation of a uniform and stable MOF layer, which otherwise appeared to be difficult to obtain. The zirconium-based MOF particle, UiO-66, played an important role in helping generate a suitable amount of reactive oxygen species under vis to promote DA polymerization, which in turn significantly facilitated the MOF film formation. By introducing rose bengal into the MOF film, excellent photodynamic antibacterial activities against Gram-positive Staphylococcus aureus and Gram-negative Escherichia coli were achieved. Overall, this study provides a straightforward strategy in preparing MOF thin films on desired substrates, which may help expand the application of functionalized MOFs.

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Photosensitizing properties of hollow microcapsules built by multilayer self-assembly of poly(allylamine hydrochloride) modified with rose Bengal

Abstract: We explored a novel strategy directed to the improvement of rose Bengal fluorescence emission and photosensitization properties by supramolecular assembly into hollow microcapsules using LbL technique.

Cited by 9 publications

References 47 publications

Fabrication and Morphological Control of Nonspherical Alginate Hydrogel Particles

Fabrication and Morphological Control of Nonspherical Alginate Hydrogel Particles

Effects of polyallylamine-coated nanoparticles on the optical and photochemical properties of rose bengal

Formation and Antibacterial Performance of Metal–Organic Framework Films via Dopamine-Mediated Fast Assembly under Visible Light

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