Photoshrinkage in Polysaccharide Gels with Trivalent Metal Ions.

Okajima, Maiko K.; Nguyen, Quyen Thi; Tateyama, Seiji; Masuyama, Hideaki; Tanaka, Takumi; Mitsumata, Tetsu; Kaneko, Tatsuo

doi:10.1021/bm301440e

Cited by 19 publications

(17 citation statements)

References 18 publications

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“…Polysaccharides are natural polymers obtained from renewable sources; they are low cost, highly soluble, and highly stable. In many studies, bacterial polysaccharides such as cellulose [14], alginate [15], xanthan gum [16], and gellan gum [17] were reported as basic hydrogel components. Xanthan gum, a microbial-derived polysaccharide, formed a hydrogel through coordination bonds with Fe 3+ cations and showed a gel-sol conversion by a reducing agent [18].…”

Section: Introductionmentioning

confidence: 99%

Preparation of Succinoglycan Hydrogel Coordinated With Fe3+ Ions for Controlled Drug Delivery

Jeong

Kim

et al. 2020

Polymers

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Hydrogel materials with a gel-sol conversion due to external environmental changes have potential applications in a wide range of fields, including controlled drug delivery. Succinoglycans are anionic extracellular polysaccharides produced by various bacteria, including Sinorhizobium species, which have diverse applications. In this study, the rheological analysis confirmed that succinoglycan produced by Sinorhizobium meliloti Rm 1021 binds weakly to various metal ions, including Fe2+ cations, to maintain a sol form, and binds strongly to Fe3+ cations to maintain a gel form. The Fe3+-coordinated succinoglycan (Fe3+-SG) hydrogel was analyzed by attenuated total reflection Fourier transform infrared (ATR-FTIR) spectroscopy, circular dichroism (CD), and field-emission scanning electron microscopy (FE-SEM). Our results revealed that the Fe3+ cations that coordinated with succinoglycan were converted to Fe2+ by a reducing agent and visible light, promoting a gel-sol conversion. The Fe3+-SG hydrogel was then successfully used for controlled drug delivery based on gel-sol conversion in the presence of reducing agents and visible light. As succinoglycan is nontoxic, it is a potential material for controlled drug delivery.

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Section: Introductionmentioning

confidence: 99%

Preparation of Succinoglycan Hydrogel Coordinated With Fe3+ Ions for Controlled Drug Delivery

Jeong

Kim

et al. 2020

Polymers

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“…These properties of sacran and the above-mentioned importance of porous hydrogels motivated us to create tough and porous gels with molecular orientation of sacran LC chains. 13,14…”

Section: Introductionmentioning

confidence: 99%

Tough and Porous Hydrogels Prepared by Simple Lyophilization of LC Gels

2017

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Porous hydrogels possessing mechanical toughness were prepared from sacran, a supergiant liquid crystalline (LC) polysaccharide produced from Aphanothece sacrum . First, layered hydrogels were prepared by thermal cross-linking of film cast over a sacran LC solution. Then, anisotropic pores were constructed using a freeze-drying technique on the water-swollen layered hydrogels. Scanning electron microscopic observation revealed that pores were observable only on the side faces of sponge materials parallel to the layered structure but never on the top or bottom faces. The pore size, porosity, and swelling behavior were controlled by the thermal-cross-linking temperature. To clarify the freezing effect, a freeze–thawing method was used for comparison. The freeze–thawed hydrogels also formed layers but no pores. The mechanical properties and network structures of hydrogels were also studied, clarifying that porous hydrogels, even those with a high quantity of pores, were tough owing to the pores orienting along the layer direction like tunnels.

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“…Next, the photoreaction result of anionic gel connected with the metal cation was visualized. As a result, the gel of sacran with trivalent metal ions gradually contracts depending on the photoirradiation energy, while alginate gel as a comparison degrades [ 49 ].…”

Section: Aphanothece Sacrummentioning

confidence: 99%

The Use of Megamolecular Polysaccharide Sacran in Food and Biomedical Applications

et al. 2021

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Natural polymer is a frequently used polymer in various food applications and pharmaceutical formulations due to its benefits and its biocompatibility compared to synthetic polymers. One of the natural polymer groups (i.e., polysaccharide) does not only function as an additive in pharmaceutical preparations, but also as an active ingredient with pharmacological effects. In addition, several natural polymers offer potential distinct applications in gene delivery and genetic engineering. However, some of these polymers have drawbacks, such as their lack of water retention and elasticity. Sacran, one of the high-molecular-weight natural polysaccharides (megamolecular polysaccharides) derived from Aphanothece sacrum (A. sacrum), has good water retention and elasticity. Historically, sacran has been used as a dietary food. Moreover, sacran can be applied in biomedical fields as an active material, excipient, and genetic engineering material. This article discusses the characteristics, extraction, isolation procedures, and the use of sacran in food and biomedical applications.

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Photoshrinkage in Polysaccharide Gels with Trivalent Metal Ions.

Cited by 19 publications

References 18 publications

Preparation of Succinoglycan Hydrogel Coordinated With Fe3+ Ions for Controlled Drug Delivery

Preparation of Succinoglycan Hydrogel Coordinated With Fe3+ Ions for Controlled Drug Delivery

Tough and Porous Hydrogels Prepared by Simple Lyophilization of LC Gels

The Use of Megamolecular Polysaccharide Sacran in Food and Biomedical Applications

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