Photostability enhancement by encapsulation of α-tocopherol into lipid-based nanoparticles loaded with a UV filter

Niculae, Gabriela; Lăcătuşu, Ioana; Bors, Alin; Stan, Raluca

doi:10.1016/j.crci.2013.12.007

Cited by 36 publications

(27 citation statements)

References 31 publications

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“…Entrapment efficiency (EE) and drug loading (DL) of the NLCs were evaluated to prove the compatibility effect of plant seed oil in the development of NLCs loaded with UV filter . There were statistically significant differences ( p < 0.05) in EE and DL of NLCs.…”

Section: Resultsmentioning

confidence: 99%

“…To remove the water, the NLCs was frozen at −80 °C overnight before lyophilisation using freeze dryer (Martin Christ, Germany) at −55 °C for 48 h. Lyophilization was performed during the optimization process of the synthesis to improve the physical and microbiological stability of the formulations. The lyophilization protocol was adapted, with slight modifications, from the method described by Niculae et al…”

Section: Methodsmentioning

confidence: 99%

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Development of Nanostructured Lipid Carriers (NLCs) Using Pumpkin and Kenaf Seed Oils with Potential Photoprotective and Antioxidative Properties

Chu

Tan

Nyam

2019

Euro J Lipid Sci & Tech

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Both pumpkin and kenaf seed oil with carnauba wax (CW) and beeswax (BW) are used to develop nanostructured lipid carriers (NLCs) loaded with Uvinul T150 and Uvinul A Plus Granular for a UV protection formulation. The study aims to optimize the concentration and the type of seed oil in order to develop a stable NLC formulation with high entrapment efficiency, drug loading, antioxidant activities, and UV absorbing properties. The physical properties of the NLCs are analyzed based on the mean particle size, polydispersity index (PDI), long‐term storage stability, Fourier‐transform infrared spectroscopy (FT‐IR), and differential scanning calorimetry (DSC). They are also compared for their entrapment efficiency, drug loading, in vitro antioxidant activities, and in vitro UV absorbing properties. The optimized NLC consists of 10% lipid phase and 1% Uvinul T150 and Uvinul A Plus Granular, respectively. It has mean particle size of 238.20 ± 3.61 nm and remains physically stable on storage at both 25 ± 2 and 40 ± 2 °C. Spherical amorphous NLC structure with encapsulated UV filters is observed by transmission electron microscopy (TEM). Besides, it shows high entrapment efficiency (≥95%) for both Uvinul T150 and Uvinul A Plus Granular in addition to its antioxidant activities as indicated by both DPPH and ABTS radical scavenging activities. In addition, the formulation had high UV absorbing properties, showing its potential to be utilized in the formation of sunscreen prototype. Practical Application: The preliminary study on pumpkin and kenaf seed oil shows bioactive potential with high antioxidant activities. The finding of kenaf seed oil‐NLC can be applied in the cosmetic industry to produce a wide variety of environmental‐friendly products with improved stability and beneficial properties. Also, the application of technology by forming NLCs can be used to develop lotions, creams, etc., with multifunctional properties. Besides, NLCs as carriers for UV filters is proven in the present study to exhibit high entrapment efficiency and drug loading properties. This is beneficial in developing advanced cosmetic prototypes that possess broad spectrum effectiveness with fewer side effects. Nanostructure lipid carriers (NLCs) are applied to encapsulate UV filters with pumpkin and kenaf seed oils. Kenaf seed oil‐NLC (F7) is selected as the best formulation for UV filters encapsulation. With spherical amorphous NLC structure, it shows high entrapment efficiency for the UV filters and antioxidant activities. Results indicate that F7 with high UV absorbing properties remains physically stable upon 12 weeks of storage period.

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Section: Resultsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Development of Nanostructured Lipid Carriers (NLCs) Using Pumpkin and Kenaf Seed Oils with Potential Photoprotective and Antioxidative Properties

Chu

Tan

Nyam

2019

Euro J Lipid Sci & Tech

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“…Niculae et al . found that different surfactants can form particles with different diameters, while several authors agree that smaller particles and lower PDIs are obtained with increasing surfactant concentration . An increase in mean particle diameter and PDI was associated with higher proportion of vitamin E by Ying et al .…”

Section: Characterization Of Slns/nlcs Loaded With Vitamin Ementioning

confidence: 93%

“…Niculae et al . formulated NLCs with VE in a previously prepared cream. They lyophilized the nanoparticles before addition to the cream.…”

Section: Formulation Of Lipid Nanoparticles Loaded With Vitamin Ementioning

confidence: 99%

Lipid nanoparticles (SLN & NLC) for delivery of vitamin E: a comprehensive review

Sáez

Souza

Mansur

2018

Intern J of Cosmetic Sci

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The antioxidative and photoprotective properties of vitamin E have caused it to be included as an active agent in various pharmaceutical and cosmetic products. However, its lipophilicity, chemical instability and poor skin penetration have limited the effectiveness of these formulations. For that reason, many attempts to include it in different drug delivery systems have been made. In recent decades, lipid nanoparticles have received special attention due to their advantages of compatibility with the skin, ability to enhance penetration of drugs in the stratum corneum, protection of the encapsulated substance against degradation induced by the external medium and control of drug release. This work reviews the current status of the encapsulation of vitamin E in lipid nanoparticles. We describe the most important methods for obtaining and characterizing lipid nanoparticles containing vitamin E (LNP-VE), various techniques for the evaluation of vitamin E's properties after encapsulation, the main in vitro and in vivo studies of the potential effectiveness or toxicity of LNP-VE, the formulations and stability studies of this delivery system, the commercial products based on LNP-VE and the regulatory aspects related to lipid nanoparticles. Finally, we discuss the most relevant advantages of encapsulating vitamin E in such particles and critical aspects that still demand attention to enhance the potential of solid lipid nanoparticles to deliver vitamin E.

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“…has led to high fluorescent and improved antioxidant properties [21][22][23][24][25]. Nanostructured lipid carriers (NLC) are colloidal carrier systems composed of physiological lipid materials and surfactants accepted as GRAS [26,27] with high drug loading, encapsulation efficiency and stability [28][29][30] and, most importantly, they may increase bioavailability and stability of bioactive compounds and provide controlled release of encapsulated materials [31,32]. They have been accepted by regulatory authorities for application in cutaneous drug delivery (e.g., topical, dermal and transdermal) for both cosmetic and pharmaceutical areas [33,34].…”

Section: Introductionmentioning

confidence: 99%

Influence of basil oil extract on the antioxidant and antifungal activities of nanostructured carriers loaded with nystatin

Badea

Bors

Lăcătuşu

et al. 2015

Comptes Rendus Chimie

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Photostability enhancement by encapsulation of α-tocopherol into lipid-based nanoparticles loaded with a UV filter

Cited by 36 publications

References 31 publications

Development of Nanostructured Lipid Carriers (NLCs) Using Pumpkin and Kenaf Seed Oils with Potential Photoprotective and Antioxidative Properties

Development of Nanostructured Lipid Carriers (NLCs) Using Pumpkin and Kenaf Seed Oils with Potential Photoprotective and Antioxidative Properties

Lipid nanoparticles (SLN & NLC) for delivery of vitamin E: a comprehensive review

Influence of basil oil extract on the antioxidant and antifungal activities of nanostructured carriers loaded with nystatin

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