Nanosecond near resonant excitation in As50S50 thin films leads to strong nonlinear optical response, i.e. nonlinear absorption coefficient up to 4 × 10 6 cm/GW and nonlinear refractive index of 8.5 cm 2 /GW, both of which is the strongest ever reported in amorphous semiconductors. We propose a five-level energy model to explain such effect which indicates that nonlinear process is reverse saturable absorption in nature, mediated by excited state absorption from triplet-triplet transition. On the other hand, observation of negative nonlinear refractive index reveals the occurrence of self-defocusing effect. Finally, benefitting from the strong nonlinear response, we demonstrate a promising application of As50S50 thin films as an optical limiter for optoelectronic sensors.