Photoswitchable diarylethenes: From molecular structures to biological applications

CuS/Co-Ferrocene-MOF Nanocomposites for Photothermally Enhanced Chemodynamic Antibacterial Therapy

“…Bacterial infection has become a serious threat to public health. − Antibiotics have long been the most effective drugs against bacterial infections, but the overuse of antibiotics has led to an increased rate of illness and increased microbial resistance to antibiotics. − Therefore, the development of emerging functional nanomaterials or antibacterial technologies with antidrug-resistant and anti-infective properties will help protect wounds and treat drug-resistant bacterial infections. − Chemodynamic therapy (CDT) is a promising antibacterial therapy that harnesses Fenton or Fenton-like reactions catalyzed by nanomaterials to generate hydroxyl radical (·OH) from H 2 O 2 in the infected microenvironment to induce bacterial death. − The advancement of potent Fenton or Fenton-like reagents is crucial for achieving effective CDT, making it a central focus in the field of nanomedicine. In the past decade, there have been several promising Fenton or Fenton-like reagents introduced and developed for CDT, such as noble metal-based nanomaterials, , metal oxide-based nanomaterials, − carbon-based nanomaterials, − and metal–organic frameworks (MOF)-based nanomaterials. − Among them, the porous nano-MOF have been extensively studied in biomedical fields recently due to their low toxicity and good biocompatibility. − However, they usually display limited or insignificant Fenton-like catalytic activity, which hinders their effectiveness for CDT.…”

Recent Advances on Diarylethene‐Based Photoswitching Materials: Applications in Bioimaging, Controlled Singlet Oxygen Generation for Photodynamic Therapy and Catalysis

“…Existing reviews on DAE-based systems have compiled the structural advancements of the DAE-based compounds for various biological applications, their evolution as photochromic fluorophore, and construction of supramolecular metallacycles and metallacages. [47][48][49] However, the coverage of all these crucial aspects of bioimaging, singlet oxygen generation and its applications in PDT and catalysis is not well documented under an umbrella. Moreover, a clear relationship on the structural vs functional properties of DAEbased systems is much required as a one-stop solution for building a strong background of such systems.…”

Amplified photomodulation of a bis(dithienylethene)-substituted phosphine

“…Diarylethenes (DAEs) are amongst the principal molecular photoswitches used for the development of light-responsive compounds, materials and processes. [1][2][3][4][5][6][7] In part, this is due to the excellent photochemical properties that most DAEs exhibit, namely reversible photoisomerization between ringopen (o) and ring-closed states (c) with high thermal stability, conversion efficiency and fatigue resistance. 1,2 In addition, DAEs undergo large geometrical and electronic changes upon o-c photoswitching, a feature that is exploited to accomplish light-control in a variety of applications (e.g., information storage and processing, 1,2,8 chemical reactivity and catalysis, 5,9,10 soft matter actuators 4,6 and (bio)imaging 3,11 ).…”