Photoswitchable molecular tweezers: isomerization to control substrate binding, and what about<i>vice versa</i>?

Wezenberg, Sander J.

doi:10.1039/d2cc04329g

Cited by 29 publications

(28 citation statements)

References 118 publications

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“…This influence is either ascribed to electronic effects or to stabilization of the photogenerated Z -isomer by a substrate that is able to bridge the binding motifs. Further research will be necessary to dissect these contributions and to improve our understanding of how substrate binding affects isomerization behavior …”

Section: Anion Capture and Releasementioning

confidence: 99%

Stimulus-Controlled Anion Binding and Transport by Synthetic Receptors

2023

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Anionic species are omnipresent and involved in many important biological processes. A large number of artificial anion receptors has therefore been developed. Some of these are capable of mediating transmembrane transport. However, where transport proteins can respond to stimuli in their surroundings, creation of synthetic receptors with stimuli-responsive functions poses a major challenge. Herein, we give a full overview of the stimulus-controlled anion receptors that have been developed thus far, including their application in membrane transport. In addition to their potential operation as membrane carriers, the use of anion recognition motifs in forming responsive membrane-spanning channels is discussed. With this review article, we intend to increase interest in transmembrane transport among scientists working on host–guest complexes and dynamic functional systems in order to stimulate further developments.

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Section: Anion Capture and Releasementioning

confidence: 99%

Stimulus-Controlled Anion Binding and Transport by Synthetic Receptors

2023

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“…50 Further studies regarding utilizing M−Φ interactions for ion and guest capture have been recently reviewed elsewhere. 62 Tailoring of M−Φ interactions could be achieved through addition of other non-stimuli-responsive linkers, i.e., Φ implemented as one of multiple ligands in molecular complexes, resulting in a Φ−M−L structural motif (Figure 2). 42 Rational design of such Φ−M−L multi-component systems could result in cooperativity between the metal center and photochromic (Φ) as well as non-photochromic (L) ligands.…”

Section: ■ Molecular Complexesmentioning

confidence: 99%

“…Additionally, strategic coupling of visible-light-activated molecules with solubility in aqueous media is still a limiting factor in applying photochromic chelators for environmental sensing technologies . Further studies regarding utilizing M−Φ interactions for ion and guest capture have been recently reviewed elsewhere …”

Section: Molecular Complexesmentioning

confidence: 99%

Metal–Photoswitch Friendship: From Photochromic Complexes to Functional Materials

et al. 2022

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Cooperative metal–photoswitch interfaces comprise an application-driven field which is based on strategic coupling of metal cations and organic photochromic molecules to advance the behavior of both components, resulting in dynamic molecular and material properties controlled through external stimuli. In this Perspective, we highlight the ways in which metal–photoswitch interplay can be utilized as a tool to modulate a system’s physicochemical properties and performance in a variety of structural motifs, including discrete molecular complexes or cages, as well as periodic structures such as metal–organic frameworks. This Perspective starts with photochromic molecular complexes as the smallest subunit in which metal–photoswitch interactions can occur, and progresses toward functional materials. In particular, we explore the role of the metal–photoswitch relationship for gaining fundamental knowledge of switchable electronic and magnetic properties, as well as in the design of stimuli-responsive sensors, optically gated memory devices, catalysts, and photodynamic therapeutic agents. The abundance of stimuli-responsive systems in the natural world only foreshadows the creative directions that will uncover the full potential of metal–photoswitch interactions in the coming years.

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“…[14][15][16][17] Over the years, tremendous efforts have been devoted in the development of mono-, di-and multitopic molecular hosts for binding various ionic guests, [18][19][20][21][22][23][24][25][26][27] and recent studies have also been extended to responsive hosts featuring switchable ion binding ability. [28][29][30][31][32] In general, critical to a successful ion receptor is the precise spatial arrangement of the ion binding motifs within the receptor skeleton. 33,34 However, designing and synthesizing a highly complementary receptor in terms of structure and surface interactions for a particular ionic guest are usually non-trivial, not to mention the engineering and control of additional mechanisms to achieve responsiveness and adaptability.…”

Section: Introductionmentioning

confidence: 99%

Dynamic mechanostereochemical switching of a co-conformationally flexible [2]catenane controlled by specific ionic guests

Yao

Tse

Lai

et al. 2023

Preprint

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Responsive synthetic receptors for adaptive recognition of different ionic guests in a competitive environment are valuable molecular tools for not only ion sensing and transport, but also the development of ion-responsive smart materials and related technologies. By virtue of the mechanical chelation and ability to undergo large-amplitude co-conformational changes, described herein is the discovery of a chameleon-like [2]catenane that selectively binds copper(I) or sulfate ions and its associated co-conformational mechanostereochemical switching. This work highlights not only the advantages and versatility of catenane as a molecular skeleton in receptor design, but also its potential in constructing complex responsive systems with multiple inputs and outputs.

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Photoswitchable molecular tweezers: isomerization to control substrate binding, and what aboutvice versa?

Abstract: Functionalization of molecular photoswitches with binding entities offers control of affinity, while isomerization properties can be influenced by bound substrate.

Cited by 29 publications

References 118 publications

Stimulus-Controlled Anion Binding and Transport by Synthetic Receptors

Stimulus-Controlled Anion Binding and Transport by Synthetic Receptors

Metal–Photoswitch Friendship: From Photochromic Complexes to Functional Materials

Dynamic mechanostereochemical switching of a co-conformationally flexible [2]catenane controlled by specific ionic guests

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