Photoswitched DNA-Binding of a Photochromic Spiropyran

Andersson, Johanna; Li, Shiming; Lincoln, Per; Andréasson, Joakim

doi:10.1021/ja801968f

Cited by 189 publications

(177 citation statements)

References 18 publications

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“…Compared to other potential molecular computing methods such as DNA computing or enzymes, spiropyrans are small molecules that can be coupled to a multitude of biological processes and the form of these molecules can be used to affect those processes. For example, proteins can have their binding properties altered (Sakata et al, 2005b); membrane permeability can be perturbed to allow molecules to cross (Ohya et al, 1998); and DNA sequences can be blocked from transcription (Andersson et al, 2008). Many other possibilities exist, both with NitroBIPS, other photochromic molecules and other molecular switches.…”

Section: Discussionmentioning

confidence: 99%

Photochromic molecular implementations of universal computation

2014

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Unconventional computing is an area of research in which novel materials and paradigms are utilised to implement computation. Previously we have demonstrated how registers, logic gates and logic circuits can be implemented, unconventionally, with a biocompatible molecular switch, NitroBIPS, embedded in a polymer matrix. NitroBIPS and related molecules have been shown elsewhere to be capable of modifying many biological processes in a manner that is dependent on its molecular form. Thus, one possible application of this type of unconventional computing is to embed computational processes into biological systems. Here we expand on our earlier proof-of-principle work and demonstrate that universal computation can be implemented using NitroBIPS. We have previously shown that spatially localised computational elements, including registers and logic gates, can be produced. We explain how parallel registers can be implemented, then demonstrate an application of parallel registers in the form of Turing machine tapes, and demonstrate both parallel registers and logic circuits in the form of elementary cellular automata. The Turing machines and elementary cellular automata utilise the same samples and same hardware to implement their registers, logic gates and logic circuits; and both represent examples of universal computing paradigms. This shows that homogenous photochromic computational devices can be dynamically repurposed without invasive reconfiguration. The result represents an important, necessary step towards demonstrating the general feasibility of interfacial computation embedded in biological systems or other unconventional materials and environments.

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Section: Discussionmentioning

confidence: 99%

Photochromic molecular implementations of universal computation

2014

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“…The photochromic species could be incorporated into the strand backbone in place of a nucleobase or ribose moiety or also by appending a photoswitch to an existing base pair. Photocontrol can also be achieved with external photochromic agents, for example, a ligand with light-dependent affinity or intercalation ability [95][96][97][98].…”

Section: Photoswitchable Nucleotidesmentioning

confidence: 99%

Photochromic Materials in Biochemistry

Wilson

Branda

2016

Photochromic Materials: Preparation, Properties and Applications

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“…[34][35][36][37][38] The combination of spiropyran units (SP) into polymer and then attaching them onto SNPs can sharply reduce the fatigue of light-responsive polymer brushes. [39] As smart dynamic materials, the spiropyran-based copolymers have particular advantages for profound and lasting applications.…”

Section: Introductionmentioning

confidence: 99%

Preparation and characterization of dual-responsive spiropyran-based random copolymer brushes via surface-initiated atom transfer radical polymerization

Liu

Yang

et al. 2016

Designed Monomers and Polymers

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(2016) Preparation and characterization of dual-responsive spiropyran-based random copolymer brushes via surfaceinitiated atom transfer radical polymerization, Designed Monomers and Polymers, 19:2, 193-204, DOI: 10.1080/15685551.2015 shenzhen institutes of advanced Technology, Chinese academy of sciences, shenzhen, P.r. China ABSTRACT Silica nanoparticles (SiO 2 ) were grafted with the precursor random copolymer of 1′-(2-acryloxyethyl)-3′,3′-dimethyl-6-nitrospiro-(2H-1-benzopyran-2,2′-indoline) (SPMA) and tert-butyl methacrylate (tBMA) by surface-initiated atom transfer radical polymerization (SI-ATRP), and SiO 2 -g-P(SPMA-comethacrylic acid (MAA)) was obtained via chemical hydrolysis of the resulting precursor random copolymer in acidic conditions. From transmission electron microscopy, we observed the spherical morphology of monodispersed silica nanoparticles and core-shell structure of SiO 2 -g-P(SPMAco-MAA). Energy dispersive spectroscopy, Fourier transform infrared spectra, X-ray photoelectron spectroscopy, and the thermogravimetric analysis indicated that the polymer had been successfully grafted onto the surface of silica nanoparticles. The dual-responsive properties were characterized by means of ultraviolet-visible spectrophotometer and dynamic light scattering. The average hydrodynamic diameter of SiO 2 -g-P(SPMA-co-MAA) increased from 185.7 to 212.7 nm under ultraviolet light irradiation for 5 min. Also, the particle size of SiO 2 -g-P(SPMA-co-MAA) increased with the rising pH value of surrounding condition.

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Photoswitched DNA-Binding of a Photochromic Spiropyran

Cited by 189 publications

References 18 publications

Photochromic molecular implementations of universal computation

Photochromic molecular implementations of universal computation

Photochromic Materials in Biochemistry

Preparation and characterization of dual-responsive spiropyran-based random copolymer brushes via surface-initiated atom transfer radical polymerization

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