Phototheranostics for multifunctional treatment of cancer with fluorescence imaging

Yin, Xiaonan; Cheng, Yifan; Feng, Yan; Stiles, Wesley R.; Park, Seung Hun; Kang, Homan; Choi, Hak

doi:10.1016/j.addr.2022.114483

Cited by 49 publications

(15 citation statements)

References 120 publications

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“…Modern theranostic agents integrated with diagnostic and therapeutic functionalities in a single platform are very promising in precision medicine because they are cost-effective and have high medicinal benefits. , Utilizing the power of light for energy transformation or transduction, phototheranostics compounds have been ideal candidates for constructing such a platform. − In the view of diagnosis, near-infrared (NIR) fluorescence imaging (FLI) is preferable because of the improved imaging depth, lower autofluorescence interference, and better sensitivity relative to conventional fluorescence imaging in the visible region. − On the other hand, photothermal therapy (PTT) and photodynamic therapy (PDT) have been identified as the two mainstream therapeutic strategies in the past decades since they are noninvasive, controllable, and with minimal drug resistance. − PTT utilizes nonradiative dissipation of excited states of a molecule to convert light energy into heat for thermal treatment, , while PDT involves a process of energy transfer from the excited molecule to an oxygen molecule to produce highly reactive singlet oxygen, which is potent reactive oxygen species (ROS) and induces cell damage and apoptosis. − But either PTT or PDT is not always sufficient for tumor ablation because they each face limitations that hinder their overall success. For instance, the temperature increase may not be high enough to obliterate the lesion, while the hypoxic microenvironment of tumor tissue may also limit ROS generation. − Therefore, compared with the independent imaging/therapeutic system, combined NIR-FLI, PTT, and PDT can provide cancer diagnosis and therapy with higher biocompatibility, accuracy, and efficiency .…”

Section: Introductionmentioning

confidence: 99%

Design of One-for-All Near-Infrared Aggregation-Induced Emission Nanoaggregates for Boosting Theranostic Efficacy

Xie

Yin

et al. 2023

ACS Nano

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Fluorescence-guided phototherapy, including photodynamic and photothermal therapy, is considered an emerging noninvasive strategy for cancer treatments. Organic molecules are promising theranostic agents because of their facile construction, simple modification, and good biocompatibility. Organic systems that integrated multifunctionalities in a single component and achieved high efficiency in both imaging and therapies are rarely reported as the inherently competitive energy relaxation pathways are hard to modulate, and fluorescence quenching occurs upon molecular aggregation. Herein, a versatile theranostic platform with near-infrared emission, high fluorescence quantum yield, robust reactive oxygen species production, and excellent photothermal conversion efficiency was developed based on an aggregation-induced emission luminogen, namely, TPA-TBT. In vivo studies revealed that the TPA-TBT nanoaggregates exhibit outstanding photodynamic and photothermal therapy efficacy to ablate tumors inoculated in a mouse model. This work offers a design strategy to develop one-for-all cancer theranostic agents by modulating and utilizing the relaxation energy of excitons in full.

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Section: Introductionmentioning

confidence: 99%

Design of One-for-All Near-Infrared Aggregation-Induced Emission Nanoaggregates for Boosting Theranostic Efficacy

Xie

Yin

et al. 2023

ACS Nano

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“…In recent years, photothermal therapy (PTT) has been widely utilized as a noninvasive and selective phototherapeutic strategy for the treatment of various types of tumors by causing damage to cancer cells through the photothermal process of light-to-heat conversion [ 1 , 2 ]. Particularly, nanomaterial-based PTT has been recognized as one of the most promising therapeutic modalities and techniques for laser-induced tumor ablation, providing the advantages of high sensitivity and specificity [ 3 ].…”

Section: Introductionmentioning

confidence: 99%

Enhanced Tumor Accumulation of Low-Molecular-Weight Hyaluronic Acid/Chitosan Nanocomplexes for Photothermal Therapy

Kim

Hyun

2023

Pharmaceutics

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Targeted phototheranostic nanosystems involving both cancer-specific near-infrared (NIR) fluorescence imaging and NIR light-induced phototherapy have shown great potential to improve cancer detection and treatment. In this study, a bifunctional nanocomplex based on low-molecular-weight hyaluronic acid (LMW-HA) and chitosan oligosaccharide lactate (COL) conjugating a zwitterionic NIR dye (ZW800-1) was rationally designed and prepared, and it was simultaneously used to enhance tumor accumulation and photothermal therapy (PTT). When HA-COL-ZW nanocomplexes were intravenously injected into mice bearing NCI-H460 tumors, HA-COL-ZW revealed increased tumor accumulation with prolonged tumor retention. Moreover, the ZW800-1 incorporated in HA-COL-ZW nanocomplexes showed excellent capability to convert NIR light into heat energy at the tumor site, acting as a PTT agent. Therefore, the targeted phototherapeutic HA-COL-ZW nanocomplex is a biocompatible and effective photothermal nanoagent, which could be a good candidate for future clinical use.

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“…Combining diagnostic and therapeutic approaches to overcome oncological diseases currently seems to be a promising strategy for cancer treatment [ 1 , 2 , 3 ]. The integration of two methods, such as photodynamic therapy (PDT) and magnetic resonance imaging (MRI), can provide an effective cancer treatment [ 4 , 5 , 6 , 7 ].…”

Section: Introductionmentioning

confidence: 99%

Design of A3B-Porphyrin Conjugates with Terpyridine as Potential Theranostic Agents: Synthesis, Complexation with Fe(III), Gd(III), and Photodynamic Activity

et al. 2023

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This paper reports on the design and synthesis of new multifunctional porphyrin-based therapeutic agents for potential therapeutic and diagnostic applications. Zinc complexes of A3B-type meso-arylporphyrins containing OH- and COOH- groups were modified with chelating ligands based on 4′-(4-methylphenyl)-2,2′:6′,2″-terpyridine derivatives in high yields. Novel complexes with Gd(III), Fe(III) were obtained for these conjugates. Aggregation behaviour in solutions of different solubilisers was studied to inform the selection of the optimal solubilising platform for the porphyrins obtained; their photophysical and photochemical properties were also characterised. Micellar Pluronic F127 formulation was found to be the most effective solubiliser for stabilising the fluorescence-active monomolecular form of the photosensitisers (PS). In vitro cytotoxicity of the compounds was studied on the HEP-2 cell line with and without irradiation for 1.5 and 24 h. As a result, the IC50 of compounds 12 and 14 at an irradiation dose of 8.073 J/cm2 was shown to be 1.87 ± 0.333 and 1.4 ± 0.152 μM, respectively; without irradiation, the compound had no toxic effect within the studied concentration range (1.5 h). A test for the inhibition of metabolic cooperation or promoter activity was also performed for the abovementioned compounds, showing the efficacy and safety of the conjugates obtained. Preliminary data have indicated the high potential of the new type of PS to be promising molecular theranostic agents.

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Phototheranostics for multifunctional treatment of cancer with fluorescence imaging

Cited by 49 publications

References 120 publications

Design of One-for-All Near-Infrared Aggregation-Induced Emission Nanoaggregates for Boosting Theranostic Efficacy

Design of One-for-All Near-Infrared Aggregation-Induced Emission Nanoaggregates for Boosting Theranostic Efficacy

Enhanced Tumor Accumulation of Low-Molecular-Weight Hyaluronic Acid/Chitosan Nanocomplexes for Photothermal Therapy

Design of A3B-Porphyrin Conjugates with Terpyridine as Potential Theranostic Agents: Synthesis, Complexation with Fe(III), Gd(III), and Photodynamic Activity

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