Phototheranostics for NIR fluorescence image guided PDT/PTT with extended conjugation and enhanced TICT

Recent Advances of Diketopyrrolopyrrole Derivatives in Cancer Therapy and Imaging Applications

“…PDBr could significantly inhibit the growth of living mouse tumors by combining PDT/PTT with the help of imaging guidance. Recently, through the use of extended conjugation and enhanced TICT effects, TPA-TDPP NPs for NIR fluorescence-image-guided PDT/PTT were reported ( Figure 10 g) [ 52 ]. A 1 O 2 production capacity of 50% and PCE of 38.7% were shown.…”

“… The structure of ( a ) AN(DPP) 2 , ( b ) TADAT , ( c ) TDADT , ( d ) DPP 2 + ], ( f ) PDBr [ 51 ], and ( g ) TPA-TDPP [ 52 ]. ( e ) Schematic of light-responsive PEG-Py with 1 O 2 capture-and-release ability for phototheranostics.…”

Achieving two-photon fluorescence bioimaging and photodynamic therapy for D–A conjugated polymers through manipulating twisted intramolecular charge transfer

“…Also, it is worth emphasizing that the existence of a heavy atom (sulfur atom) contributes to boosted spin–orbital coupling and ISC for higher 1 O 2 generation. 41…”

A comprehensive review on singlet oxygen generation in nanomaterials and conjugated polymers for photodynamic therapy in the treatment of cancer

“…These nanoparticles showed remarkable photodynamic/photothermal synergy. 162 Nave et al created a novel, straightforward technique for creating NIR light-responsive nano-systems that were utilized in cancer chemo-photodynamic/photothermal treatment. They accomplished this by creating an amphiphilic conjugate of poly(2-ethyl-2-oxazoline)-IR780 that, when combined, might encase doxorubicin (DOX/PEtOx-IR NPs) and have photodynamic/photothermal characteristics.…”