Phototherapy: a Review and Update of Treatment Options in Dermatology

Krenitsky, Amanda; Ghamrawi, Rima I.; Feldman, Steven R.

doi:10.1007/s13671-020-00290-6

Cited by 20 publications

(19 citation statements)

References 41 publications

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“…The AD activity was decreased after 3 weeks of irradiating with a cumulative dosage of 9 J/cm 2 narrowband UVB. [11][12][13] The influence of narrow-band UVB was assessed in children as well. The response was good-to-excellent in 80% (mean ages 11 years), but the most common opposing influences were erythema and xerosis.…”

Section: Discussionmentioning

confidence: 99%

Possible clinical efficacy and tolerability of platelet‐rich plasma with atopic dermatitis

Yosef

Elkady

Khattab

2021

J of Cosmetic Dermatology

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Background: Narrowband-ultraviolet B (NB-UVB) is a promising, effective, and safe therapeutic option for atopic dermatitis (AD), but the treating courses frequently need an extended period since they might have a possible hazard for several side effects and cases of non-compliance.Objective: To discover the influence of platelet-rich plasma (PRP) injecting on the outcomes of short-term NB-UVB treatment for AD cases. Patients and methods:The present study includes 44 atopic dermatitis cases with general symmetric lesions. For every case, the left side of the body was treated with NB-UVB (control side) whereas the right side was treated with NB-UVB plus PRP intradermal injection, at 3-week interval for 3-months.Results: A statistically high significant reduction was found in the EASI score, IGA score in the combined side (PRP plus NB-UVB) in comparison with NB-UVB side. Conclusion:Intradermal PRP injecting in addition to NB-UVB can be considered as a simple, acceptable, and economical method for treating atopic dermatitis. It decreases the NB-UVB therapeutic period and is predictable to raise case compliance.Assessments through follow-up were proposed and undertaken to rate the efficacy of treatment.

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Section: Discussionmentioning

confidence: 99%

Possible clinical efficacy and tolerability of platelet‐rich plasma with atopic dermatitis

Yosef

Elkady

Khattab

2021

J of Cosmetic Dermatology

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“…e early stages of cutaneous T-cell lymphoma (MF) can be managed with skin-targeted therapy [10,11]. Recent studies have demonstrated the high efficacy of NB-UVB and PUVA in MF [12]. At the same time, the data on cytokine profile at various stages and severity of MF when exposed to phototherapy are insufficient and contradictory.…”

Section: Introductionmentioning

confidence: 99%

Effect of PUVA and NB-UVB Therapy on the Skin Cytokine Profile in Patients with Mycosis Fungoides

Карамова

Verbenko

Vorontsova

et al. 2022

Journal of Oncology

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Background. Mycosis fungoides (MF) is the most common subtype of cutaneous T-cell lymphoma. The aim of the present study was to produce up-to-date information on different phototherapy approaches on skin cytokines in patients with MF. Methods. A total of 27 patients with mycosis fungoides were treated with phototherapy: NB-UVB (narrow‐band ultraviolet B therapy) (10 patients) and PUVA (long-wavelength ultraviolet radiation of spectrum A with the use of skin-photosensitizing furocoumarins) therapy (17 patients). Evaluation of the effectiveness of treatment was carried out using BSA (body surface area) and the modified assessment of the severity of the skin lesions scale (mSWAT) used to quantify tumor mass in cutaneous T-cell lymphomas. Average numbers of procedures were 30.2 and 27.8 in the NB-UVB and PUVA groups, respectively. The median total dose of NB-UVB irradiation was 19.9 J/cm2 and PUVA therapy was 104.0 J/cm2. The overall response to therapy including complete and partial remission was 74.9% in the total group; 70% in the NB-UVB group, and 77.7% in the PUVA therapy group. In the obtained biopsies from lesions, surrounding tissue before treatment and skin samples of four healthy volunteers, the concentration of the IL-1β, IL-4, IL-6, IL-10, IL-17A, IL-17F, IL-21, IL-22, IL-23, IL-25, IL-31, IL-33, IFN-γ, sCD40L, and TNF-α cytokines was studied. An increase in IL-4 and TNF-α levels was shown in the lesional skin of patients compared to the skin of healthy controls. After the treatment, positive correlations of mSWAT with the levels of IL22, IL33, and TNF-α in the tumor tissue were found. The levels of IL10 and IFN-γ after PUVA treatment were increased in comparison to baseline. There was no difference in cytokine levels before/after NB-UVB therapy.

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“…The therapeutic effect of UV was attributed mainly to vasodilation and increase in local blood perfusion [10,11]. Over more than a century of researching the influence of UV light on the skin, other properties of phototherapy-namely, anti-inflammatory, immunosuppressive, antiproliferative, and antifibrotic effects-have been discovered [12]. Thus, taking into account such an ambivalent effect of UV light on the skin, modern medicine faces the task of personalized adjustment of therapeutic radiation doses to minimize possible adverse effects.…”

Section: Introductionmentioning

confidence: 99%

Methods of Non-Invasive In Vivo Optical Diagnostics in the Assessment of Structural Changes in the Skin Induced by Ultraviolet Exposure in an Experimental Model

et al. 2021

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Background: This paper demonstrates the use of optical diagnostic methods to assess the dynamic skin changes observed in acute and chronic exposure to ultraviolet (UV) radiation in vivo. Methods: Firstly, in order to initiate photoaging (chronic UV exposure), animals (n = 40) were divided into two groups: chronic UV exposure (n = 30), and control (n = 10; without irradiation). Photoaging in animals was induced by chronic repeated exposure to UVA radiation three times per week, for 12 weeks continuously, while the UV dose increased stepwise over the course of the experiment (55 minimal erythema doses (MED) in total). Laser fluorescence spectroscopy (LFS), optical tissue oximetry (OTO), laser Doppler flowmetry (LDF), and optical coherence tomography (OCT) of the shaved dorsum skin were performed regularly, once per week until the conclusion of the study. At 0, 5, and 12 weeks of the experiment, histological examination of animal tissues using hematoxylin/eosin and Masson’s trichrome staining was performed. At the second stage, erythema was induced in mice (n = 15) by acute UV exposure at high doses. The colorimetric assay of the image from a digital RGB camera was used to evaluate the erythema index. Results: The tissue content index ηcollagen of collagen was appropriate for the characterization of skin photoaging. Significant differences (p < 0.05) in ηcollagen were found between the control and photoaging groups from the 5th to the 9th week of the experiment. In addition, the rate of collagen degradation in the control group was about half that of the photoaging group. This marker allows the differentiation of photo- and chronoaging. OCT revealed the main optical layers of the skin in compliance with the histological pattern. The analysis of the RGB camera images provided visualization of the acute skin reaction to UV radiation. Conclusions: This study demonstrates the applicability of optical methods for the quantitative assessment of acute and chronic skin effects of UV exposure in vivo.

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Phototherapy: a Review and Update of Treatment Options in Dermatology

Cited by 20 publications

References 41 publications

Possible clinical efficacy and tolerability of platelet‐rich plasma with atopic dermatitis

Possible clinical efficacy and tolerability of platelet‐rich plasma with atopic dermatitis

Effect of PUVA and NB-UVB Therapy on the Skin Cytokine Profile in Patients with Mycosis Fungoides

Methods of Non-Invasive In Vivo Optical Diagnostics in the Assessment of Structural Changes in the Skin Induced by Ultraviolet Exposure in an Experimental Model

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