Phototherapy

Abstract

The efficacy of phototherapy is based on the interaction between ultraviolet (UV) radiation and the skin. The photobiological effects thus achieved depend on the wavelengths used. Targeted use of UVA and UVB, where indicated in combination with a photosensitizer such as psoralen, provides the dermatologist with a broad armamentarium for the treatment of a multitude of skin diseases. The spectrum of indications ranges from superficial dermatitis, psoriasis, and malignancies, such as cutaneous T-cell lymphoma, to deep sclerosing conditions such as morphea. The objective of the present review is to highlight the photobiological effects of the various types of UV radiation as well as the resultant clinical indications for phototherapy.

Phototherapy: The patients' point of view

“…The therapeutic effect of UVB rays is complex and involves a shift from Th1/Th17‐ to Th2, which causes a drop in the cytokines such as IL‐17, IL‐22, and IL‐23. Moreover, UVB causes apoptosis of inflammatory cells 4 and also has effects on the innate immune system, acting on the innate lymphoid cells 5 . The mechanism of action of PUVA is based on the linkage between psoralen and DNA, causing the interruption of the cell cycle 5 …”

The Aqueous Extract of Polypodium leucotomos (Fernblock®) Regulates Opsin 3 and Prevents Photooxidation of Melanin Precursors on Skin Cells Exposed to Blue Light Emitted from Digital Devices

“…Even though ultraviolet radiation (UV, 100–400 nm) is known to be accountable for most of the skin damage [ 5 ], visible light (VIS, 400–700 nm), which represents the vast majority of the terrestrial sunlight after infrared light, has been seen to cause damage by inducing production of free radicals, DNA damage, immunosuppression, and photoaging, among others [ 6 ].…”

Efficacy of NB-UVB as Add-on Therapy to Antihistamine in the Treatment of Chronic Urticaria: A Systematic Review and Meta-analysis

“…Phototherapy is a major effective therapeutic modality in dermatology and has influenced the treatment of different skin diseases dramatically [9,10]. Ultraviolet B (UVB) phototherapy has different effects, including antiinflammatory, immunosuppressive and cytotoxic effects [11]. The mechanisms of its action are unclear but reducing skin mast cell reactivity, degranulating and releasing histamine and other pro-inflammatory mediators are possible modes of action [12,13].…”