Phototherapy and vitamin D

Juzeniene, Asta; Grigalavicius, Mantas; Juraleviciute, Marina; Grant, William B.

doi:10.1016/j.clindermatol.2016.05.004

Cited by 22 publications

(20 citation statements)

References 82 publications

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“…Photochemical reactions have significantly enriched the organic synthesis portfolio as it allows for the rapid construction of complex molecules using photons as a traceless reagent [6,7]. As a consequence, photochemical processes are currently becoming widespread [8], in particular in the search of new biologically active compounds for applications in medicine or agriculture, as well as in many other fields (healthcare, material and environmental sciences for instance) [9][10][11].…”

Section: Introductionmentioning

confidence: 99%

Photooxygenation in an advanced led-driven flow reactor module: Experimental investigations and modelling

Radjagobalou

Blanco

Dechy‐Cabaret

et al. 2018

Chemical Engineering and Processing - Process Intensification

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The photooxygenation of α-terpinene was investigated as a benchmark reaction in an advanced LED-driven flow reactor module, both from an experimental and modelling point of view. Ethanol was used as a green solvent and rose Bengal was chosen as a cheap sensitizer of industrial importance. Firstly, the kinetic law based on all mechanistic steps was established for the chosen photooxygenation. From this, the set of operating parameters potentially influencing the photoreaction rate were identified. Subsequently, experiments were carried out under continuous-flow conditions to screen these operating parameters, namely concentration of α-terpinene, concentration of photosensitizer, residence time, structure of the segmented gas-liquid flow and nature of the reagent gas phase (air versus pure oxygen). Finally, the conditions enabling minimization of sensitizer bleaching were established. It was also shown that the hydrodynamic characteristics of the gas-liquid flow can have an effect on the conversion levels. From this, a simplified model was proposed to predict the conversion at the reactor's outlet when pure oxygen was used.

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Section: Introductionmentioning

confidence: 99%

Photooxygenation in an advanced led-driven flow reactor module: Experimental investigations and modelling

Radjagobalou

Blanco

Dechy‐Cabaret

et al. 2018

Chemical Engineering and Processing - Process Intensification

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“…UVB treatment of healthy individuals and psoriasis and AD patients results in higher vitamin D 3 levels (summarized in Ref. 38). Thus, in the past years, several studies addressed the role of vitamin D 3 in AD concerning the severity of the disease and IgE serum levels but with inconsistent results (reviewed in Ref.…”

Section: Discussionmentioning

confidence: 99%

Vitamin D3–Induced Promotor Dissociation of PU.1 and YY1 Results in FcεRI Reduction on Dendritic Cells in Atopic Dermatitis

Herrmann

Nümm

Iwamoto

et al. 2021

The Journal of Immunology

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Atopic dermatitis (AD) is a severe inflammatory skin disease. Langerhans cells and inflammatory dendritic epidermal cells (IDEC) are located in the epidermis of AD patients and contribute to the inflammatory processes. Both express robustly the high-affinity receptor for IgE, Fc«RI, and thereby sense allergens. A beneficial role of vitamin D 3 in AD is discussed to be important especially in patients with allergic sensitization. We hypothesized that vitamin D 3 impacts Fc«RI expression and addressed this in human ex vivo skin, in vitro Langerhans cells, and IDEC models generated from primary human precursor cells. We show in this article that biologically active vitamin D 3 [1,25(OH) 2 -D 3 ] significantly downregulated Fc«RI at the protein and mRNA levels of the receptor's a-chain, analyzed by flow cytometry and quantitative RT-PCR. We also describe the expression of a functional vitamin D receptor in IDEC. 1,25(OH) 2 -D 3 -mediated Fc«RI reduction was direct and resulted in impaired activation of IDEC upon Fc«RI engagement as monitored by CD83 expression. Fc«RI regulation by 1,25(OH) 2 -D 3 was independent of maturation and expression levels of microRNA-155 and PU.1 (as upstream regulatory axis of Fc«RI) and transcription factors Elf-1 and YY1. However, 1,25(OH) 2 -D 3 induced dissociation of PU.1 and YY1 from the FCER1A promotor, evaluated by chromatin immunoprecipitation. We show that vitamin D 3 directly reduces Fc«RI expression on dendritic cells by inhibiting transcription factor binding to its promotor and subsequently impairs IgE-mediated signaling. Thus, vitamin D 3 as an individualized therapeutic supplement for those AD patients with allergic sensitization interferes with IgE-mediated inflammatory processes in AD patients.

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“…Moreover, Vitamin D is involved in the proliferation of keratinocytes ( Figure 3 ). In fact, the precursor of vitamin D, 7-DHC, is localized in the keratinocyte membrane, and, by the UVB activation, it is transformed into pre-vitamin D3 or cholecalciferol, which is later converted first to 25OHD by the enzymes CYP27A1 and CYP2R1 and then to 1,25(OH)D or calcitriol, the active form of vitamin D [ 1 , 49 , 50 , 51 , 52 ]. Calcitriol regulates differentiation and proliferation of keratinocytes, as well as the balance of the cutaneous immune system and cellular apoptosis.…”

Section: Current Marketed Therapiesmentioning

confidence: 99%

Psoriasis: From Pathogenesis to Pharmacological and Nano-Technological-Based Therapeutics

Petit

Cano

Ortiz

et al. 2021

IJMS

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Research in the pathogenesis of inflammatory skin diseases, such as skin dermatitis and psoriasis, has experienced some relevant breakthroughs in recent years. The understanding of age-related factors, gender, and genetic predisposition of these multifactorial diseases has been instrumental for the development of new pharmacological and technological treatment approaches. In this review, we discuss the molecular mechanisms behind the pathological features of psoriasis, also addressing the currently available treatments and novel therapies that are under clinical trials. Innovative therapies developed over the last 10 years have been researched. In this area, advantages of nanotechnological approaches to provide an effective drug concentration in the disease site are highlighted, together with microneedles as innovative candidates for drug delivery systems in psoriasis and other inflammatory chronic skin diseases.

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Phototherapy and vitamin D

Cited by 22 publications

References 82 publications

Photooxygenation in an advanced led-driven flow reactor module: Experimental investigations and modelling

Photooxygenation in an advanced led-driven flow reactor module: Experimental investigations and modelling

Vitamin D3–Induced Promotor Dissociation of PU.1 and YY1 Results in FcεRI Reduction on Dendritic Cells in Atopic Dermatitis

Psoriasis: From Pathogenesis to Pharmacological and Nano-Technological-Based Therapeutics

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