Phototherapy for Neonatal Hyperbilirubinemia: Efficacy, Mechanism and Toxicity*

Xanthobilirubic acid, 5‐[1,5‐didehydro‐3‐ethyl‐4‐methyl‐5‐oxo‐2H‐pyrrol‐2‐ylidene)methyl]‐2,4‐dimethyl‐1H‐pyrrol‐3‐propanoic acid, its methyl ester, amide, N‐methylamide and dimethylamide, and kryptopyrromethenone have been synthesized and characterized spectroscopically. In d6‐DMSO solution all pyrromethenones were monomeric, with lactam and pyrrole N‐Hs H‐bonded to solvent. In deuteriochloroform, the pyrromethenones preferred a dimeric form, with intramolecular H‐bonding between the lactam C = 0 of one unit and the lactam and pyrrole N‐Hs of the second.

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Inverse Raman spectroscopy of bilirubin and its ditauride

Hillig

Morris

1984

J Raman Spectroscopy

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The inverse Raman spectrum of bilirubin and bilirubin ditauride were measured under pre-resonant conditions. Spectra in chloroform and dimethyl sulfoxide were assigned by comparison with model compounds and on the basis of the known effects of the solvents on the internal hydrogen bonding in bilirubin. The band assignments were used to interpret the spectra of bilirubin ditauride in aqueous solution. Evidence is presented for strong hydrogen bonding to the pyrrole N-H bonds and to the lactam rings. It is proposed that hydrogen bonding to water is facilitated by photoactivation and, in turn, stabilizes photohiliruhin.

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Phototherapy for Neonatal Hyperbilirubinemia: Efficacy, Mechanism and Toxicity*

Cited by 33 publications

References 161 publications

Intermittent phototherapy versus continuous phototherapy for neonatal jaundice

Intermittent phototherapy versus continuous phototherapy for neonatal jaundice

Xanthobilirubic acid and its amides. Synthesis, spectroscopy, and solution structures

Inverse Raman spectroscopy of bilirubin and its ditauride

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