Phototherapy for Neonatal Jaundice

Ennever, John F.

doi:10.1111/j.1751-1097.1988.tb01669.x

Cited by 59 publications

(26 citation statements)

References 51 publications

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“…Longer wavelengths are able to penetrate deeper into the skin than shorter wavelengths. 15 This phenomenon has the effect of shifting the effective absorption spectrum of bilirubin from blue to green. Green and blue-green light may also be more effectively absorbed in vivo by albuminbound bilirubin.…”

Section: Discussionmentioning

confidence: 99%

“…16 Albumin, which in vivo binds bilirubin, also binds with long-chain fatty acids. 15 This cobinding results in a shift in the absorption maximum of bilirubin to longer wavelengths. 17 In addition, it has been noted that the absorption spectrum of bilirubin may be modified when bound to skin constituents 18 and by the filtering action of skin layers.…”

Section: Discussionmentioning

confidence: 99%

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A Prospective Randomized Controlled Study of Phototherapy Using Blue and Blue-Green Light-Emitting Devices, and Conventional Halogen-Quartz Phototherapy

et al. 2003

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OBJECTIVE:To determine the efficacy of blue versus blue-green phototherapy using new light sources with narrow luminous spectra. The devices made of highintensity gallium nitride light-emitting diodes (LEDs) were also compared to conventional halogen-quartz bulbs phototherapy. DESIGN:Prospective open randomized study. PARTICIPANTS:A total of 114 jaundiced, but otherwise healthy term infants who met the entry criteria for phototherapy set by the American Academy of Pediatrics' Practice Parameter. MAIN OUTCOME MEASURES:The duration of phototherapy and the rate of decrease in total serum bilirubin (TSB). RESULTS:The mean TSB concentrations at initiation and termination of treatment, as well as the duration of phototherapy and the rate of decrease in TSB, were not statistically different in newborns receiving blue LED, blue-green LED or conventional phototherapy. The average rate of decrease in TSB (slope), after adjustment by a linear regression analysis for confounding factors, was À3.61 mmol/hour (95% confidence limits À5.47, À1.75) in the 25 newborns receiving blue LED phototherapy compared with À2.57 mmol/hour (À4.32, À0.82) in the 22 newborns treated with bluegreen LED phototherapy and À3.42 mmol/hour (À5.02, À1.81) in the 57 newborns who received conventional phototherapy. CONCLUSIONS:When using low light irradiance, there was no statistically significant difference in the effectiveness of phototherapy using blue-green LEDs, blue LEDs or conventional halogen-quartz bulbs.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

A Prospective Randomized Controlled Study of Phototherapy Using Blue and Blue-Green Light-Emitting Devices, and Conventional Halogen-Quartz Phototherapy

et al. 2003

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“…The light emitted in this spectrum enters the epidermis and reaches subcutaneous tissue. Thus, only bilirubin found close to the skin surface (2 mm) is directly affected by light 7,8 .…”

Section: Mechanisms Of Actionmentioning

confidence: 94%

Treatment of neonatal hyperbilirubinemia

Carvalho¹

2001

J Pediatr (Rio J)

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Objective: to review the recent medical literature on the treatment of neonatal jaundice, focusing on practical aspects that are relevant to pediatricians and neonatologists.Sources: an extensive review of the related literature was performed, also including the author's clinical experience in this field of investigation. Summary of the findings:jaundice is very common among infants during the first days of life. Several factors such as maternal and neonatal history have to be considered before implementing treatment. Significant advances have been made in the past few years concerning the treatment of jaundiced newborn infants. This review focuses on three forms of treatment of neonatal hyperbilirubinemia: phototherapy, exchange transfusion and the use of drugs to reduce serum bilirubin concentration.Conclusions: nowadays, the in-depth knowledge about the mechanism of action of phototherapy, the development of intensified phototherapy units and the use of drugs to reduce bilirubin formation, have contributed to significantly decrease the need for exchange transfusion.

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“…The development of treatments involving UV light, actinotherapy and photomedicine led to positive effects in helping patients suffering from rickets (vitamin D defi ciency), together with claims of healing boils, carbuncles, neo-natal jaundice and for pain relief. [1][2][3] Following the production of the fi rst laser in 1960, itself a comparatively low-powered instrument, research into other lasers such as helium-neon (633 nm) followed. In Eastern Europe in the late 1960s, workers such as Mester, 4 encouraged by laboratory experiments into regenerative healing effects in mice, treated patients with open wounds where conventional therapies had failed, reporting success rates of 85%.…”

Section: Photobiostimulation Backgroundmentioning

confidence: 99%