Phototherapy for sclerosing skin conditions

Vasquez, Rebecca; Jacobe, Heidi

doi:10.1586/edm.11.67

Cited by 4 publications

(6 citation statements)

References 88 publications

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“…Generally, products of this type are used as active photosensitizers in psoralen and UVA (PUVA) therapy. Thus, furocoumarins can be employed in treatment of various skin diseases [15][16][17][18][19][20][21][22]. In this regard, the development of new methods for the synthesis of products containing the furocoumarin moiety is of considerable interest.…”

Section: Introductionmentioning

confidence: 99%

2-(2-(4-Methoxyphenyl)-4,9-dimethyl-7-oxo-7H-furo[2,3-f]chromen-3-yl)acetic Acid

Lichitsky

Komogortsev

Melekhina

2021

Molbank

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For the first time, we describe a new approach towards the synthesis of previously unknown 2-(2-(4-methoxyphenyl)-4,9-dimethyl-7-oxo-7H-furo[2,3-f]chromen-3-yl)acetic acid. The presented method is based on the multicomponent condensation of 5-hydroxy-4,7-dimethyl-2H-chromen-2-one, 4-methoxyphenylglyoxal and Meldrum’s acid. It was shown that the studied reaction proceeds in two steps including the initial interaction of starting materials in MeCN and the final formation of furylacetic acid moiety in acidic media. The structures of the obtained compound were established by 1H, 13C-NMR spectroscopy and high-resolution mass spectrometry.

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Section: Introductionmentioning

confidence: 99%

2-(2-(4-Methoxyphenyl)-4,9-dimethyl-7-oxo-7H-furo[2,3-f]chromen-3-yl)acetic Acid

Lichitsky

Komogortsev

Melekhina

2021

Molbank

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“…MMP-1, also called interstitial collagenase, is vital in breaking down collagen types I, II, and III. As shown in cultured human skin fibroblasts, UVB irradiation also lowers transforming growth factor-1 (TGF-1) and type I collagen expression at the mRNA and protein levels [2].…”

Section: Discussionmentioning

confidence: 95%

“…Protokół leczenia oparto na pracach Kreutera i wsp. oraz Vasquez i Jacobe [1,2]. Badacze ci stosowali protokół podobny do zalecanego w łuszczycy: trzy sesje fototerapii tygodniowo; dawka promieniowania u pacjentów z fototypami skóry I i II w skali Fitzpatricka równa 100 mJ/cm 2 , zwiększana o 100 mJ/cm 2 po każdej sesji aż do dawki maksymalnej 1300 mJ/cm 2 (z punktem końcowym określonym jako wystąpienie nieznacznego rumienia) oraz stosowaniem emolien- up the interplay between the systems and pathogenesis.…”

Section: Discussionunclassified

“…Narrow-band UVB (311-313 nm) was chosen as the modality in this patient due to the inability to administer systemic immunosuppressants owing to the elevated liver enzymes. The treatment protocol was based on a study by Kreuter et al and Vasquez and Jacobe, who used a protocol similar to the psoriasis protocol with phototherapy performed three times a week, with the phototherapy dose for Fitzpatrick skin types I and II of 100 mJ/cm 2 with an incremental increase of 100 mJ/cm 2 on each visit with a maximum dose of 1300 mJ/cm 2 with an endpoint of slight erythema and followed by emollients immediately after [1,2]. Treatment was carried out for twenty sessions dolnej.…”

Section: Opis Przypadkumentioning

confidence: 99%

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Narrow-band ultraviolet B as a treatment option in linear morphea

Wirya¹,

Suryawati²,

Wirya³

et al. 2022

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Introduction: Morphea, also known as localized scleroderma, is a condition characterized by fibrosis of the skin and underlying tissue. Linear morphea is an infrequent condition especially in adults. Treatment of morphea is challenging because of its recalcitrant nature. Therapeutic options include the use of phototherapy and systemic immunosuppressants with variable success. Phototherapy used in morphea also varies, with ultraviolet A1 (UVA1) being the most frequently used therapy; however, the availability of UVA1 is scarce and may increase the risk of skin cancer. Narrow-band ultraviolet B (NB-UVB) is much more readily available and presents a much lower risk of skin cancer. Case report: Here we report a 27-year-old adult male with linear morphea on his lower extremity treated using NB-UVB. The patient underwent twenty sessions of NB-UVB and showed remarkable response to therapy. Conclusions: This case report further highlights a treatment option for linear morphea using NB-UVB.

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“…Scores were divided into categories: 0-1 = no effect, 2-5 = small effect, 6-10 = moderate effect, 11-20 = very large effect, and 21-30 = extremely large effect from their skin disease. 12 Itching and pain were assessed on a visual analog scale (VAS) 13 of 1-10, with 10 indicating greatest severity.…”

Section: Methodsmentioning

confidence: 99%

The role of skin trauma in the distribution of morphea lesions: A cross-sectional survey of the Morphea in Adults and Children cohort IV

Grabell

Hsieh

Andrew

et al. 2014

Journal of the American Academy of Dermatology

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Background Skin trauma may play a role in the development of morphea lesions. The association between trauma and the distribution of cutaneous lesions has never been examined. Objective Determine whether patients enrolled in the Morphea in Adults and Children (MAC) cohort exhibit skin lesions distributed in areas of prior (isotopic) or ongoing (isomorphic) trauma. Methods Cross-sectional analysis of the MAC cohort. Results Of 329 patients in the MAC cohort, 52 (16%) had trauma associated lesions at the onset of disease. Patients with lesions in an isotopic distribution had greater clinical severity as measured by a clinical outcome measure (mean modified Rodnan Skin Score of 13.8 vs. 5.3, P=0.004, 95% CI=3.08-13.92) and impact on life quality (mean Dermatology Life Quality Index 8.4 vs. 4.1, P=0.009, 95% CI 1.18-7.50) than those with an isomorphic distribution. Most frequent associated trauma were chronic friction (isomorphic) and surgery/isotopic. Limitations Recall bias for patient reported events. Conclusion Sixteen percent of patients in the MAC cohort developed initial morphea lesions at sites of skin trauma. If these findings can be confirmed in additional series, they suggest that elective procedures and excessive skin trauma or friction might be avoided in these patients.

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Phototherapy for sclerosing skin conditions

Cited by 4 publications

References 88 publications

2-(2-(4-Methoxyphenyl)-4,9-dimethyl-7-oxo-7H-furo[2,3-f]chromen-3-yl)acetic Acid

2-(2-(4-Methoxyphenyl)-4,9-dimethyl-7-oxo-7H-furo[2,3-f]chromen-3-yl)acetic Acid

Narrow-band ultraviolet B as a treatment option in linear morphea

The role of skin trauma in the distribution of morphea lesions: A cross-sectional survey of the Morphea in Adults and Children cohort IV

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