Phototherapy: From Ancient Egypt to the New Millennium

McDonagh, Antony F.

doi:10.1038/sj.jp.7210625

Cited by 71 publications

(41 citation statements)

References 13 publications

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“…The reactivity of 1 O 2 with biomolecules (e.g., membranes and lipids), amino acids (e.g., His, Trp, and Met), and nucleic acids (e.g., guanosine) as model systems to help in understanding the mechanism of toxiciy in PDT (Cadet et al , 2006; Girotti, 2001; Itri et al , 2014; McDonagh, 2001; Kanofsky, 1989). Reaction of 1 O 2 with methionine is an example of heteroatom oxidation in proteins (Fig.…”

Section: Type I and Ii Photosensitized Oxidation Reactionsmentioning

confidence: 99%

On thein vivophotochemical rate parameters for PDT reactive oxygen species modeling

Kim¹,

Ghogare²,

Greer³

et al. 2017

Phys. Med. Biol.

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Photosensitizer photochemical parameters are crucial data in accurate dosimetry for photodynamic therapy (PDT) based on photochemical modeling. Progress has been made in the last few decades in determining the photochemical properties of commonly used photosensitizers (PS), but mostly in solution or in-vitro. Recent developments allow for the estimation of some of these photochemical parameters in-vivo. This review will cover the currently available in-vivo photochemical properties of photosensitizers as well as the techniques for measuring those parameters. Furthermore, photochemical parameters that are independent of environmental factors or are universal for different photosensitizers will be examined. Most photosensitizers discussed in this review are of the type II (singlet oxygen) photooxidation category, although type I photosensitizers that involve other reactive oxygen species (ROS) will be discussed as well. The compilation of these parameters will be essential for ROS modeling of PDT.

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Section: Type I and Ii Photosensitized Oxidation Reactionsmentioning

confidence: 99%

On thein vivophotochemical rate parameters for PDT reactive oxygen species modeling

Kim¹,

Ghogare²,

Greer³

et al. 2017

Phys. Med. Biol.

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“…Although phototherapy has been used for the treatment of neonatal jaundice for more than 4 decades, the most efficacious phototherapy method with the least side effects has not been developed yet (1-3). Its efficacy is dependent on the color (wavelength) and intensity (irradiance) of the light emitted during phototherapy, the exposed body surface area, and the duration of exposure (2, 4-6).…”

Section: Introductionmentioning

confidence: 99%

“…Its efficacy is dependent on the color (wavelength) and intensity (irradiance) of the light emitted during phototherapy, the exposed body surface area, and the duration of exposure (2, 4-6). The currently available phototherapy devices such as fluorescent tubes, halogen spotlights and fiberoptic blankets have many disadvantages including high heat production and unstable broad wavelength light output (1, 7, 8). In cases of severe or rapidly increasing neonatal jaundice, it is important to institute intensive phototherapy to decrease the bilirubin levels as soon as possible to reduce the need for exchange transfusion and the risk of kernicterus (9-11).…”

Section: Introductionmentioning

confidence: 99%

In vitro and in vivo Efficacy of New Blue Light Emitting Diode Phototherapy Compared to Conventional Halogen Quartz Phototherapy for Neonatal Jaundice

et al. 2005

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High intensity light emitting diodes (LEDs) are being studied as possible light sources for the phototherapy of neonatal jaundice, as they can emit high intensity light of narrow wavelength band in the blue region of the visible light spectrum corresponding to the spectrum of maximal bilirubin absorption. We developed a prototype blue gallium nitride LED phototherapy unit with high intensity, and compared its efficacy to commercially used halogen quartz phototherapy device by measuring both in vitro and in vivo bilirubin photodegradation. The prototype device with two focused arrays, each with 500 blue LEDs, generated greater irradiance than the conventional device tested. The LED device showed a significantly higher efficacy of bilirubin photodegradation than the conventional phototherapy in both in vitro experiment using microhematocrit tubes (44±7% vs. 35±2%) and in vivo experiment using Gunn rats (30±9% vs. 16±8%). We conclude that high intensity blue LED device was much more effective than conventional phototherapy of both in vitro and in vivo bilirubin photodegradation. Further studies will be necessary to prove its clinical efficacy.

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“…Neonatal jaundice is common and only rarely (and mainly in infants with bilirubin levels of >20 mg/dl) leads to the serious condition of kernicterus that has mortality in excess of 10% and long-term morbidity in excess of 70% 16. Most evidence suggests that phototherapy works principally by converting bilirubin to less lipophilic isomers that are excreted more readily in urine and bile, and to a lesser extent by degrading bilirubin to colourless water soluble degradation products that are excreted in urine 17 18…”

Section: Introductionmentioning

confidence: 99%

Risk of skin cancer after neonatal phototherapy: retrospective cohort study

Brewster

Tucker

Fleming

et al. 2010

Archives of Disease in Childhood

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Although there is no statistically significant evidence of an excess risk of skin cancer following NNPT, limited statistical power and follow-up duration mean it is not possible categorically to rule out an effect. However, taken in conjunction with the results of the only other study to investigate risk of melanoma following NNPT, evidence available so far does not suggest a major cause for concern.

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Phototherapy: From Ancient Egypt to the New Millennium

Cited by 71 publications

References 13 publications

On thein vivophotochemical rate parameters for PDT reactive oxygen species modeling

On thein vivophotochemical rate parameters for PDT reactive oxygen species modeling

In vitro and in vivo Efficacy of New Blue Light Emitting Diode Phototherapy Compared to Conventional Halogen Quartz Phototherapy for Neonatal Jaundice

Risk of skin cancer after neonatal phototherapy: retrospective cohort study

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