Phototherapy of Cancer and Atheromatous Plaque with Texaphyrins

Woodburn, Kathryn W.; Fan, Quli; Kessel, David; Wright, Meredith; Mody, Tarak D.; Hemmi, Gregory; Magda, Darren; Sessler, Jonathan L.; Dow, William C.; Miller, Richard A.; Young, Stuart W.

doi:10.1089/clm.1996.14.343

Cited by 88 publications

(68 citation statements)

References 7 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Approved initially for the treatment of a small number of selected tumors (1), it has expanded to encompass a wide range of applications in dermatology (2,3), ophthalmology (4,5), dentistry (6,7), cardiology (8,9), cosmetics (10,11), blood purification (12), and water disinfection (13,14).…”

Section: Photodynamic Therapy (Pdt)mentioning

confidence: 99%

Effect of Molecular Characteristics on Cellular Uptake, Subcellular Localization, and Phototoxicity of Zn(II) N-Alkylpyridylporphyrins

Ezzeddine¹,

Al-Banaw

Tovmasyan

et al. 2013

Journal of Biological Chemistry

View full text Add to dashboard Cite

Background: Delivering molecules to selected cellular compartments is important for analytical and practical purposes. Results: Varying the length and positions of alkyl substituents results in preferential uptake of zinc porphyrins by particular cellular structures. Conclusion: Uptake, distribution, and phototoxicity of porphyrins depend on charge, lipophilicity, and molecular shape. Significance: Systematic chemical modification provides the basis for rational design of molecules targeting specific cellular compartments.

show abstract

Section: Photodynamic Therapy (Pdt)mentioning

confidence: 99%

Effect of Molecular Characteristics on Cellular Uptake, Subcellular Localization, and Phototoxicity of Zn(II) N-Alkylpyridylporphyrins

Ezzeddine¹,

Al-Banaw

Tovmasyan

et al. 2013

Journal of Biological Chemistry

View full text Add to dashboard Cite

show abstract

“…Photodynamic therapy (PDT), also called photochemotherapy, is a new modality for the treatment of cancer [1][2][3] and a variety of nononcologic conditions [3][4][5][6][7]. PDT is based on administering a photosensitizer, which is preferentially retained in tumor (and other proliferating) tissue.…”

Section: Introductionmentioning

confidence: 99%

Photodynamic parameters in the chick chorioallantoic membrane (CAM) bioassay for topically applied photosensitizers

Hammer‐Wilson

Akian

Espinoza

et al. 1999

Journal of Photochemistry and Photobiology B: Biology

View full text Add to dashboard Cite

“…This agent is visible at MR imaging, which shortens T1 time to increase signal intensity at T1-weighted imaging. In addition, the fluorescent properties of MGd enable it to be detected with a confocal microscope, with emitted fluorescence at 740 nm when excited at 470 nm (12,13).…”

Section: Contrast Agentmentioning

confidence: 99%

3.0-T MR Imaging of Intracoronary Local Delivery of Motexafin Gadolinium into Coronary Artery Walls

Meng¹,

Wang²,

Sun³

et al. 2013

Radiology

View full text Add to dashboard Cite

Purpose:To develop a technique with clinical 3.0-T magnetic resonance (MR) imaging to delineate local contrast agent distribution in coronary artery walls for potential molecular MR imaging-guided local gene or drug therapy of atherosclerotic coronary artery disease. Materials and methods:This animal protocol was approved by the institutional animal care and use committee and was in compliance with the Guide for the Care and Use of Laboratory Animals. For in vitro confirmation, human arterial smooth muscle cells (SMCs) were used to determine capability of SMCs in uptake of motexafin gadolinium (MGd) and its optimal dose. For ex vivo evaluation, a 2-mL mixture of MGd and trypan blue was locally infused into coronary artery walls of six cadaveric pig hearts with MR monitoring and an MR imaging guidewire, surface coils, or both. For in vivo validation, the balloon catheter was placed into coronary arteries of seven living pigs, and the MGd and trypan blue mixture was infused into arterial walls with MR guidance. Signal-to-noise ratio (SNR) and contrast-to-noise ratio (CNR) of coronary artery walls were recorded by using different coils between pre-and postcontrast infusion, with subsequent histologic confirmation. Paired Student t tests were used to compare average SNRs and CNRs of arterial walls before and after contrast agent infusion with different coils. Results:SMCs could take up MGd with the optimal concentration at 150 µmol/L. Average SNR with the MR imaging guidewire and surface coil combination was significantly higher than that with the MR imaging guidewire only or with surface coils only (P , .05), and average SNR and CNR of postinfusion MR imaging was significantly higher than that of preinfusion MR imaging (P , .05). Histologic analysis was used to confirm successful intracoronary infiltration of MGd and trypan blue within coronary artery walls. Conclusion:MR imaging can be used to delineate locally infused contrast agent distribution in coronary artery walls. This establishes groundwork for development of molecular MR imaging-guided intracoronary therapy.q RSNA, 2013 Supplemental material: http://radiology.rsna.org/lookup /suppl

show abstract

Phototherapy of Cancer and Atheromatous Plaque with Texaphyrins

Cited by 88 publications

References 7 publications

Effect of Molecular Characteristics on Cellular Uptake, Subcellular Localization, and Phototoxicity of Zn(II) N-Alkylpyridylporphyrins

Effect of Molecular Characteristics on Cellular Uptake, Subcellular Localization, and Phototoxicity of Zn(II) N-Alkylpyridylporphyrins

Photodynamic parameters in the chick chorioallantoic membrane (CAM) bioassay for topically applied photosensitizers

3.0-T MR Imaging of Intracoronary Local Delivery of Motexafin Gadolinium into Coronary Artery Walls

Contact Info

Product

Resources

About