Phototherapy Today

Synthesis and Biological Activity of N‐Aroyl (Aryloxyacetyl)‐N′‐ferrocenyl Thiourea Derivatives

“…Pure compound 5a was isolated by column chromatography. Yield: 78.5%; mp: 110-112°C; 1 The other complexes (5b-i) were synthesized by similar procedure of N-benzoyl-Nferrocenylthiourea (5a) using appropriate substituted benzoic (aryloxyacetic) acid.…”

“…Considerable efforts have been made to develop new pesticides, plant growth regulators, and other insecticides to overcome global food shortage. In 1968, acylthiourea compounds were first introduced as insecticides and attracted global interest. The application of acylthiourea derivatives in the biomedical field has been extensively investigated in the past decades because of their easy degradability, high efficiency, and low toxicity.…”

“…H NMR (CDCl 3 , 400 Hz): δ (ppm) 12.04 (s, 1H, C(S)−NH), 8.92 (s, 1H, C(O)−NH), 7.81 (d, J = 8.0, 2H, Ar-H), 7.27 (d, J = 8.0, 2H, Ar-H), 4.75 (s, 2H, C 5 H 4 ), 4.21 (s, 5H, C 5 H 5 ), 4.10 (s, 2H, C 5 H 4 ), 2.38 (s, 3H, CH 3 ). IR (cm −1 ): ν(N−H) 3494, 3219; ν (C═O)1660; ν(C═S) 1368.Synthesis of N-(2-Methoxybenzoyl)-N -ferrocenyl Thiourea (5f)Yield: 85%, mp: 158-160°C 1. H NMR (CDCl 3 , 400 Hz): δ (ppm) 12.24 (s, 1H, C(S)−NH), 11.04 (s, 1H, C(O)−NH), 8.20 (d, J = 7.84, 1H, Ar-H), 7.60 (t, J = 7.84, 1H, Ar-H), 7.16 (t, J = 7.56, 1H, Ar-H), 7.06 (d, J = 4.36, 1H, Ar-H), 4.84 (s, 2H, C 5 H 4 ), 4.27 (s, 5H, C 5 H 5 ), 4.15 (s, 2H, C 5 H 4 ), 4.09 (s, 3H, OCH 3 ).…”