Photothermal conversion-coordinated Fenton-like and photocatalytic reactions of Cu2-xSe-Au Janus nanoparticles for tri-combination antitumor therapy

Wang, Yuanlin; Li, Zhenglin; Hu, Ying; Liu, Jing; Guo, Mengyu; Wei, Hengxiang; Zheng, S.; Jiang, Tingting; Sun, Xin; Ma, Zhong; Sun, Yuxiu; Besenbacher, Flemming; Chen, Chunying

doi:10.1016/j.biomaterials.2020.120167

Cited by 101 publications

(72 citation statements)

References 53 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The temperature profiles of all these GNR@Cu 2-x Se heterostructures almost remain unchanged after five cycles of consecutive laser on/off irradiation, suggesting the high photothermal stability of these materials. Thus, we conclude that all these GNR@Cu 2-x Se heterostructures have excellent NIR-II photothermal performance with the η value ranging from 58-85% consistent with previously reported η values in the literature 26 , 58 - 60 , highlighting their potential as durable photothermal agents for NIR-II photothermal tumor ablation.…”

Section: Resultssupporting

confidence: 90%

Rationally designed dual-plasmonic gold nanorod@cuprous selenide hybrid heterostructures by regioselective overgrowth for in vivo photothermal tumor ablation in the second near-infrared biowindow

Shan¹,

Wang²,

Li³

et al. 2020

Theranostics

View full text Add to dashboard Cite

NIR-II plasmonic materials offer multiple functionalities for in vivo biomedical applications, such as photothermal tumor ablation, surface-enhanced Raman scattering biosensing, photoacoustic imaging, and drug carriers. However, integration of noble metals and plasmonic semiconductors is greatly challenging because of the large lattice-mismatch. This study reports the regioselective overgrowth of Cu 2-x Se on gold nanorods (GNRs) for preparation of dual-plasmonic GNR@Cu 2-x Se hybrid heterostructures with tunable NIR-II plasmon resonance absorption for in vivo photothermal tumor ablation. Methods: The regioselective deposition of amorphous Se and its subsequent conversion into Cu 2-x Se on the GNRs are performed by altering capping agents to produce the GNR@Cu 2-x Se heterostructures of various morphologies. Their photothermal performances for NIR-II photothermal tumor ablation are evaluated both in vitro and in vivo . Results: We find that the lateral one- and two-side deposition, conformal core-shell coating and island growth of Cu 2-x Se on the GNRs can be achieved using different capping agents. The Cu 2-x Se domain size in these hybrids can be effectively adjusted by the SeO 2 concentration, thereby tuning the NIR-II plasmon bands. A photothermal conversion efficiency up to 58-85% and superior photostability of these dual-plasmonic hybrids can be achieved under the NIR-II laser. Results also show that the photothermal conversion efficiency is dependent on the proportion of optical absorption converted into heat; however, the temperature rise is tightly related to the concentration of their constituents. The excellent NIR-II photothermal effect is further verified in the following in vitro and in vivo experiments. Conclusions: This study achieves one-side or two-side deposition, conformal core-shell coating, and island deposition of Cu 2-x Se on GNRs for GNR@Cu 2-x Se heterostructures with NIR-II plasmonic absorption, and further demonstrates their excellent NIR-II photothermal tumor ablation in vivo . This study provides a promising strategy for the rational design of NIR-II dual-plasmonic heterostructures and highlights their therapeutic in vivo potential.

show abstract

Section: Resultssupporting

confidence: 90%

Rationally designed dual-plasmonic gold nanorod@cuprous selenide hybrid heterostructures by regioselective overgrowth for in vivo photothermal tumor ablation in the second near-infrared biowindow

Shan¹,

Wang²,

Li³

et al. 2020

Theranostics

View full text Add to dashboard Cite

show abstract

“…In another example, Yu et al integrated the Cu 2−x Se with Au NPs to form Cu 2−x Se-Au JNPs. [38] The amorphous Cu 2−x Se semi-enclosed shell could largely enhance Fenton-like reaction properties than the crystalline Cu 2−x Se. Meanwhile, like Cu 2−x Se NPs, the LSPR effect of the Au core could also convert the irradiated light into heat.…”

Section: Janus Nps ( Jnps)mentioning

confidence: 99%

Recent Advances in Nanomaterial‐Based Nanoplatforms for Chemodynamic Cancer Therapy

Jiang

et al. 2021

Adv Funct Materials

282

158

View full text Add to dashboard Cite

Triggered by the endogenous chemical energy in the tumor microenvironment (TME), chemodynamic therapy (CDT) as an emerging non-exogenous stimulant therapeutic modality has received increasing attention in recent years. The chemodynamic agents can convert internal hydrogen peroxide (H 2 O 2 ) into the lethal reactive oxygen species (ROS) hydroxyl radicals ( • OH) for oncotherapy. Compared with other therapeutic modalities, CDT possesses many notable advantages, such as tumor-specific, highly selective, fewer systemic side effects, and no need for external stimulation. Nevertheless, mild acid pH, low H 2 O 2 content, and overexpressed reducing substance in TME severely suppressed the CDT efficiency. With the rapid development of nanotechnology, some kinds of nanomaterials have been utilized with improved CDT efficiency. In particular, the excellent photo-, ultrasound-, magnetic-, and other stimuli-response properties of nanomaterials make it possible for combination cancer therapy of CDT with other therapeutic modalities, and it has shown superior anti-cancer activity than monotherapies. Therefore, it is necessary to summarize the application of nanomaterial-based chemodynamic cancer therapy. In this review, the various nanomaterials-based nanoplatforms for CDT and its combinational therapies are summarized and discussed, aiming to provide inspiration for the design of better-quality agents to promote the CDT development and lay the foundation for its future conversion to clinical applications.

show abstract

“…The reaction rate and degree of Fenton reaction for CDT are influenced by the reaction conditions. [152][153][154] Especially, the local temperature elevation can expedite the Fenton reaction rate and enhance the reaction degree for ROS production. [155][156][157][158][159] On this ground, we recently designed photothermal-enhanced Fenton composite nanocatalysts for synergistic PTT and CDT against tumor, which were based on Fe 3 O 4 /GOD-functionalized polypyrrole (PPy) nanoparticles (Figure 11b).…”

Section: Chemodynamic Therapymentioning

confidence: 99%

Emerging Nanomedicine‐Enabled/Enhanced Nanodynamic Therapies beyond Traditional Photodynamics

et al. 2021

View full text Add to dashboard Cite

Figure 3. a) Scheme for the constructed Fe(III)/TPPS nanosonosensitizer for synergistic sonotheranostics by RGD-enabled tumor targeting, downregulated SOD2 expression, GSH depletion, Fenton reaction-triggered hydroxyl radicals and SDT. Reproduced with permission. [38] Copyright 2019, Wiley-VCH. b) Schematic illustration of the design principle and mechanism of combinatorial SDT and immunotherapy, including nanosonosensitizer-enabled and SDT-induced antitumor immune responses and checkpoint blockade for tumor immunotherapy. Reproduced under the terms of the CC-BY Creative Commons Attribution 4.

show abstract

Photothermal conversion-coordinated Fenton-like and photocatalytic reactions of Cu2-xSe-Au Janus nanoparticles for tri-combination antitumor therapy

Cited by 101 publications

References 53 publications

Rationally designed dual-plasmonic gold nanorod@cuprous selenide hybrid heterostructures by regioselective overgrowth for in vivo photothermal tumor ablation in the second near-infrared biowindow

Rationally designed dual-plasmonic gold nanorod@cuprous selenide hybrid heterostructures by regioselective overgrowth for in vivo photothermal tumor ablation in the second near-infrared biowindow

Recent Advances in Nanomaterial‐Based Nanoplatforms for Chemodynamic Cancer Therapy

Emerging Nanomedicine‐Enabled/Enhanced Nanodynamic Therapies beyond Traditional Photodynamics

Contact Info

Product

Resources

About