Photothermal detection of gold nanoparticles using phase-sensitive optical coherence tomography

Adler, Desmond C.; Huang, Shu‐Wei; Huber, Robert; Fujimoto, James G.

doi:10.1364/oe.16.004376

Cited by 216 publications

(188 citation statements)

References 62 publications

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“…Optical Coherence Tomography (OCT) uses the scattering function of gold nanoshells for in vivo imaging. (Agrawal, Huang et al 2006;Adler, Huang et al 2008;Skrabalak, Chen et al 2008) The accumulation of gold nanoshells at the tumour increases scattering at that location that provides the contrast. Another imaging tool for gold nanomaterials is using photoacoustic imaging.…”

Section: Nanoparticles For Optical Imagingmentioning

confidence: 99%

Nanoparticles in Biomedical Applications and Their Safety Concerns

Choi¹,

Wang²

2011

Biomedical Engineering - From Theory to Applications

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Section: Nanoparticles For Optical Imagingmentioning

confidence: 99%

Nanoparticles in Biomedical Applications and Their Safety Concerns

Choi¹,

Wang²

2011

Biomedical Engineering - From Theory to Applications

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“…Using the surface-enhanced Raman scattering (SERS) effect, the sensitivity of reporter dye molecules, directly attached to the surface of GNPs through Au-S or Au-N interactions, can be greatly enhanced and this hybrid may be used for more sensitive cancer cell imaging (Christiansen et al 2007;Lu et al 2010;Jiang et al 2011). Optical coherence tomography (OCT) uses the scattering function of gold nanoshells for in vivo imaging Adler et al 2008;Skrabalak et al 2008).…”

Section: Nanoparticles As Imaging and Contrast Enhancer Agentsmentioning

confidence: 99%

Nanomaterials for biomedical applications

Das

Mitra

Khurana

et al. 2013

Frontiers in Life Science

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Nanotechnology involves understanding and manipulating materials normally in the size range of 1 to 100 nm, where particles show completely novel physico-chemical properties from their bulk counterpart. In the last two decades a number of precisely engineered nanomaterials have been developed for diagnostic and therapeutic applications. For diagnostic applications, nanoparticles allow detection at the molecular scale. Some fluorescent nanohybrids can serve the dual purpose of detection and destruction of pathogenic microbes. The specificity and sensitivity of magnetic resonance imaging can be greatly improved by using nanoparticles as contrast enhancement material. As therapeutic agent, they allow targeted delivery and sustained release of drug molecules and they also have huge potential in tissue engineering. Given the vast range of application of nanomaterials in the biomedical domain, this review focuses on the major nanoparticle based diagnostic and therapeutic modalities.

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“…[13][14][15] For instance, GNPs in combination with surface plasmon resonance and surface enhanced Raman scattering increase the sensitivity of imaging systems. [16][17][18][19] GNPs were also used for other therapeutic applications, such as targeted drug delivery. [20][21][22][23][24][25] One cancer killing mechanism study indicates that GNPs effectively increase the absorption of radiation leading to thermal denaturation and coagulation of cancerous cells as a result of surface plasmon resonance.…”

Section: Introductionmentioning

confidence: 99%

Treating cancer stem cells and cancer metastasis using glucose-coated gold nanoparticles

Hu¹,

Niestroj²,

Yuan³

et al. 2015

IJN

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Cancer ranks among the leading causes of human mortality. Cancer becomes intractable when it spreads from the primary tumor site to various organs (such as bone, lung, liver, and then brain). Unlike solid tumor cells, cancer stem cells and metastatic cancer cells grow in a non-attached (suspension) form when moving from their source to other locations in the body. Due to the non-attached growth nature, metastasis is often first detected in the circulatory systems, for instance in a lymph node near the primary tumor. Cancer research over the past several decades has primarily focused on treating solid tumors, but targeted therapy to treat cancer stem cells and cancer metastasis has yet to be developed. Because cancers undergo faster metabolism and consume more glucose than normal cells, glucose was chosen in this study as a reagent to target cancer cells. In particular, by covalently binding gold nanoparticles (GNPs) with thio-PEG (polyethylene glycol) and thio-glucose, the resulting functionalized GNPs (Glu-GNPs) were created for targeted treatment of cancer metastasis and cancer stem cells. Suspension cancer cell THP-1 (human monocytic cell line derived from acute monocytic leukemia patients) was selected because it has properties similar to cancer stem cells and has been used as a metastatic cancer cell model for in vitro studies. To take advantage of cancer cells’ elevated glucose consumption over normal cells, different starvation periods were screened in order to achieve optimal treatment effects. Cancer cells were then fed using Glu-GNPs followed by X-ray irradiation treatment. For comparison, solid tumor MCF-7 cells (breast cancer cell line) were studied as well. Our irradiation experimental results show that Glu-GNPs are better irradiation sensitizers to treat THP-1 cells than MCF-7 cells, or Glu-GNPs enhance the cancer killing of THP-1 cells 20% more than X-ray irradiation alone and GNP treatment alone. This finding can help oncologists to design therapeutic strategies to target cancer stem cells and cancer metastasis.

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Photothermal detection of gold nanoparticles using phase-sensitive optical coherence tomography

Cited by 216 publications

References 62 publications

Nanoparticles in Biomedical Applications and Their Safety Concerns

Nanoparticles in Biomedical Applications and Their Safety Concerns

Nanomaterials for biomedical applications

Treating cancer stem cells and cancer metastasis using glucose-coated gold nanoparticles

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